Recipient Organization
UNIV OF CALIFORNIA (VET-MED)
(N/A)
DAVIS,CA 95616
Performing Department
MEDICINE AND EPIDEMIOLOGY
Non Technical Summary
Pyoderma is caused most frequently by Staphylococcus, a type of bacteria. Other bacteria, such as E. coli, also can invade previously infected skin. Several risk factors may cause an animal to be more likely to develop pyoderma. These risk factors include: Parasites, such as fleas or mange mites, Allergies, such as flea, food, contact, or hereditary allergies, Hormonal disorders, such as hypothyroidism (low production of thyroid hormone by the thyroid gland), Inadequate immune system, such as in young animals or those taking steroids, Animals with short coats, skin folds, or calloused skin, and Trauma. The results of this study will provide more evidence for the potential beneficial effects of pradofloxacin for the treatment of superficial and deep pyoderma.
Animal Health Component
(N/A)
Research Effort Categories
Basic
(N/A)
Applied
(N/A)
Developmental
100%
Goals / Objectives
This project is a clinical trial using a canine model to test the efficacy of pradofloxacin, an antibiotic for treating superfial and/or deep bacterial skin infection.
Project Methods
We hypothesize that skin concentrations of pradofloxacin in dogs with pyoderma will be significantly higher than those of dogs without pyoderma, with a correlation depicted between the degree of leukocyte infiltration and concentration of the drug. The tissue concentration of pradofloxacin is expected to be at least several fold greater than the 90% minimum inhibitory concentration of pradofloxacin for Staphyloccus intermedius, the most common isolate of pyoderrma.