Source: UNIVERSITY OF CALIFORNIA, RIVERSIDE submitted to NRP
FINANCIAL SUPPORT FOR 24TH SYMPOSIUM IN PLANT BIOLOGY
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0207922
Grant No.
2006-35304-17404
Cumulative Award Amt.
(N/A)
Proposal No.
2006-03422
Multistate No.
(N/A)
Project Start Date
Sep 15, 2006
Project End Date
Sep 14, 2007
Grant Year
2006
Program Code
[53.0]- (N/A)
Recipient Organization
UNIVERSITY OF CALIFORNIA, RIVERSIDE
(N/A)
RIVERSIDE,CA 92521
Performing Department
BOTANY AND PLANT SCIENCES
Non Technical Summary
Recent years have witnessed a tremendous leap in our understanding of microRNAs, small interfering RNAs and chromatin modifications as universal (i.e. in both plant and animals) regulatory mechanisms governing development, physiology and responses to pathogens. The mechanisms underlying small RNA biogenesis, chromatin modification, and their functions in gene regulation are being uncovered at a rapid pace. Plants appear to extensively exploit small RNA pathways in various processes and several ground-breaking discoveries in small RNA biology were made in plants. The aim of this symposium is to bring together students and scientists studying small RNAs and chromatin from different perspectives - plant, animal, genetic, molecular, biochemical, and cell biological - to highlight these recent advances and identify emerging questions to be addressed for dissection of small RNA biology and epigenetic regulation. As natural antiviral agents in both plants and animals, small RNAs hold tremendous promises in fighting viral infection and in agriculture and medicine. As sequence-specific regulators of gene expression, small RNAs form the basis of technologies to achieve targeted gene expression to improve agriculture and human health. By stimulating research in small RNA biology, the proposed symposium will meet at least two of the goals of the CSREES Strategic Plan in enhancing protection and safety of the Nation's agriculture and food supply and in improving the Nation's nutrition and health.
Animal Health Component
5%
Research Effort Categories
Basic
90%
Applied
5%
Developmental
5%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
2012499100020%
2012499105020%
2012499108020%
2032499103020%
2062499104020%
Goals / Objectives
The aim of this symposium is to bring together not only well-established scientists, but also as many young, talented scientists as possible, who approach small RNAs and the epigenome in mainly plant but also non-plant organisms and from different but complementary conceptual and technical perspectives. Thus, the symposium will generate an interdisciplinary synthesis and synergy in this fast-moving area of research. The symposium format will provide a constructive forum for sustained, focused, in-depth discussions to promote learning, interaction, collaboration, and resource sharing among researchers in this field.
Project Methods
The winter Symposium in Plant Biology at the University of California, Riverside has a long and successful history as an internationally recognized forum for advancing current plant science research in a small meeting format. The establishment of the Center for Plant Cell Biology (CEPCEB) and the UCR Institute for Integrative Genome Biology in recent years successfully recruited outside talents as well as synergized existing strengths in the plant science such that UCR now emerges as a place where cutting-edge research in plant science is conducted with genomic, bioinformatic, cellular, molecular and biochemical approaches. The symposium will be held at the Riverside Convention Center, which is within a 3 minute walk to nearby hotels. The symposium will span three days, beginning midday on January 18, 2007. The symposium comprises five sessions: (I) Small RNA biogenesis and action mechanisms; (II) Small RNA function in development; (III) Small RNA function in stress and other physiological processes; (IV) Transcriptional silencing and DNA methylation; (V) Transcriptional silencing and histone modifications. Each session will consist of 20 minute talk/5 min discussion by 25 invited prominent speakers followed by 10 minute talk/5 minute discussion by speakers selected from abstracts. Priority will be given to new PIs, postdoctoral fellows and graduate students when making poster talk selections.

Progress 09/15/06 to 09/14/07

Outputs
The symposium 'Gene Silencing: The Biology of Small RNAs and the Epigenome' was held January 18-20, 2007 at the Riverside Convention Center in Riverside, California. The hosting organization for the symposium was the Institute for Integrative Genome Biology (IIGB) at the University of California, Riverside (UCR). IIGB was established in 2000 to pioneer solutions for hunger, disease and environmental sustainability by encouraging collaborations among life and physical scientists, mathematicians and engineers from such diverse fields as genomics, public policy studies, and the medical sciences. 'Gene Silencing: The Biology of Small RNAs and the Epigenome,' the 24th Symposium in Plant Biology at UCR, was the first major conference convened by the Institute for Integrative Genome Biology. Organizers of the symposium were: Xuemei Chen, Associate Professor of Plant Cell and Molecular Biology; Shou-Wei Ding, Professor and Plant Pathologist; and Jian-Kang Zhu, Professor of Plant Cell Biology. All three are participants in the Center for Plant Cell Biology (CEPCEB) in the UCR Institute for Integrative Genome Biology, as well as pioneers in the investigation on small RNA biogenesis and the role of miRNAs in plant development. Total symposium attendance was 319, making it the best attended UCR Symposium in Plant Biology. The symposium program included 38 invited session speakers, including 11 early career investigators and one industry representative. The early career investigator speakers were selected by the organizers from the abstracts subtracts submitted online, with two of these 11 speakers from UC institutions. Due to the overwhelming response by attendees to submit their work in poster format, 100 posters were presented at the four poster sessions scheduled throughout the symposium, including 19 by UC graduate students, postdocs and faculty. In addition to the promotion of scientifc exchange and collaboration, the symposium also served as an educational tool, promoting interactions among graduate students and postdoctoral researchers with some of the world's leading senior-level investigators of microRNAs (miRNAs) and small interfering RNAs (siRNAs) in plant and non-plant organisms. In particular, graduate students enrolled in the Gene Silencing course (GEN206) were able to attend the symposium and learn about gene silencing from experts at the forefront of the field. These graduate students were from diverse graduate programs at UC Riverside, including Botany and Plant Sciences, Plant Pathology, Genetics, Genomics and Bioinformatics, and Cell, Molecular, and Developmental Biology.

Impacts
It is safe to say that the symposium was the best in the past five years in both comprehensive and in-depth coverage on the topic of small RNAs and epigenetics in plants. Many of the invited speakers are the leading international figures in the field. Examples include, but are not limited to, David Baulcombe (who was the first to detect small RNAs in association with gene silencing), David Bartel (who was one of the first to show that numerous microRNAs are present in animals), James Carrington (who first isolated endogenous small RNAs from plants), Vicki Chandler (who is famous for her studies on paramutation in maize), Marjori Matzke (who was one of the first to have discovered transcriptional gene silencing), and Shou-Wei Ding (who was the first to demonstrate that RNA silencing is an antiviral defense mechanism in animals). Among the invited speakers and speakers selected from registrants were also young, emerging stars in the field. These included Steve Jacobsen, Olivier Voinnet, Yijun Qi, Xuemei Chen and Jiankang Zhu. Many participants at the symposium expressed a strong interest in having such symposiums on a regular basis in the future. Several journal editors and two NSF officers were at the symposium. This provided researchers a rare opportunity to interact in person with people who make decisions on publication or funding issues related to their research. In summary, this symposium provided a great platform for presenting cutting edge research and sharing unpublished results and an opportunity for forging collaborations and bonding among colleagues.

Publications

  • No publications reported this period