Progress 07/01/04 to 06/30/07
Outputs
The Illinois-Missouri Biotechnology Alliance's research base and productivity remain robust at a time when crucial food and energy issues confront our nation. Researchers receiving IMBA funds continue to produce practical, credible and innovative discoveries and knowledge for the corn and soybean sectors. From basic research that is unlocking the secrets of how plants defend themselves against drought and pests to broader issues of health and consumer economics, researchers receiving IMBA support are systematically contributing to a stronger agricultural sector and informed citizenry. The Alliance supports projects that have a high probability to improve the incomes of corn and soybean producers, and rural communities, as a result of commercialization of improved varieties or value-added products. Ten new projects were funded and eight projects are being completed and Final Reports submitted on each one. The new projects: [1] Entrepreneurial and Organizational Response
to Biotechnology Innovation; [2] Discovery and Modification of Photomorphogenic Regulation in Maize; [3] Genomic Evaluation of the Defense Response of Maize Against Herbivory by the Western Corn Rootworm; [4] Metabolic Engineering of Soybean for Enhanced Sucrose and Oil Content; [5] Systematically Assigning Gene Function in Soybean Employing RNAi; [6] Trait-Based Modeling of GM Corn Adoption; [7] Assessing the Opportunities of Soy Food for Consumers, Markets and Public Policy; [8] Expression of Anti-Nematode Proteins in Transgenic Soybean to Control Soybean Cyst Nematode; [9] Mechanisms of Soybean Oil Deposition and Increasing Oil Content Through Genetic Engineering; and [10] Development of Soybean Germplasm With Designed Resistance to Soybean Rust and Other Diseases. The past year included an external assessment of the IMBA operating model to identify features that have contributed to success and areas where changes might foster even greater success. According to the researchers,
many IMBA projects produced prototype plant materials and technologies meriting further testing or commercialization. These included transgenic lines, markers, plant constructs, improved seed lines, improved technology services, and processing technology techniques and improvements. They noted, however, that many studies required long term commitments after IMBA initial funding to realize a commercialized product or service. The researchers found that IMBA proposals clearly identified research outcomes as goals, and many identified practical uses and end-users for their work. Less effort was made to involve industry in the eventual outcome of their work. When this was done, there were direct benefits in research alliances that provided further testing of research outcomes or further developing outputs. They also learned that conventional biotechnology research has a shorter time to reach implementation than does basic biotechnology research and that IMBA projects anticipated timeline
to commercialization was shorter when industry interest was fostered and maintained throughout the research process.
Impacts
An independent research team evaluated fifteen IMBA-funded projects that were plant biotechnology focused, and four projects that investigated methods for improving uses of corn or soybean products. It was their conclusion that regardless of the emphasis on plant biotechnology or utilization technology, there was a high performance level among investigators involved with these IMBA studies; with the most effective results coming from researchers who gave early consideration to how their results would be translated into tangible, valuable products for commercialization. According to the independent team, the results of basic biotechnology research funded by IMBA, combined with results of other studies, lead to developmental research conducted by private firms. The results of the developmental efforts lead to prototype technology, which is subsequently refined and ultimately commercialized through adaptive research and technology transfer programs, some of which are
conducted by public agencies and institutions. Sometimes the path by which the basic research results find their way to practical application is so complex that the connection to the basic research is [difficult to measure]. For the nineteen projects reviewed, the independent team found that in addition to producing tangible outcomes for possible commercialization, the IMBA researchers are active in documenting their progress in the form of peer reviewed publications and presentations at scientific meetings. Applications for at least four patents are in progress, one of which was successful.
Publications
- Andjelkovic, D.D. and Larock, R.C. 2006. Novel rubbers from cationic copolymerization of soybean oils and dicyclopentadiene. 1. Synthesis and characterization. Biomacromolecules 2006, 7, 927-936.
- Fang, M., Kremer, R.J., Motavalli, P.P. and Davis, G. 2005. Bacterial diversity in rhizospheres of nontransgenic and transgenic corn. Applied and Environmental Microbiology 71, 4132-4136.
- Fang, M., et.al. 2006. Assessing changes in soil microbial communities and carbon mineralization in Bt and non-Bt corn residue-amended soils. (In Review).
- Henna, P.H., Andjelkovic, D.D., Kundu, P.P. and Larock, R.C. 2007. Biobased thermosets from the free-radical copolymerization of conjugated linseed oil. Journal of Applied Polymer Science 2007, 104, 979-985.
- Holt, D.A. and Nash, M.L. 2006. Anticipating research outcomes. In: Annual meetings abstracts [CD-ROM]. ASA, CSSA, and SSSA, Madison, WI.
- Larock, R.C., Li, F. and Lu, Y. 2006. Bio-based thermoset plastic composite materials and methods of making same. U.S. patent, Appl. No. 60/839918, 2006 (In Review).
- Lu, Y. and Larock, R.C. 2006. Novel biobased nanocomposites from soybean oil and functionalized organoclay. Biomacromolecules 2006, 7, 2692-2700.
- Lu, Y. and Larock, R.C. 2006. Corn oil based composites reinforced with continuous glass fibers: Fabrication and properties. Journal of Applied Polymer Science 2006, 102, 3345-3353.
- Lu, Y. and Larock, R.C. 2007. Bio-based nanocomposites from corn oil and functionalized organoclay by cationic polymerization. Polymer (Submitted).
- Lu, Y. and Larock, R.C. 2007. Fabrication, morphology and properties of soybean oil-based composites reinforced with continuous glass fibers. Macromolecular Materials and Engineering (Submitted).
- Motavalli, P.P., Kremer, R.J., Fang, M. and Means, N.E. 2004. Impact of genetically-modified crops and their management on soil microbially mediated plant nutrient transformations. Journal of Environmental Quality 33, 816-824.
- Mungai, N.W., Motavalli, P.P., Nelson, K.A. and Kremer, R.J., 2005. Differences in yields, residue composition and N mineralization dynamics of Bt and non-Bt maize. Nutrient Cycling in Agroecosystems, 73, 101-109.
- Phartiyal, P., Kim, W-S., Cahoon, R.E., Jez, J.M. and Krishnan, H.B. 2006. Soybean ATP sulfurylase, a homodimeric enzyme involved in sulfur assimilation, is abundantly expressed in roots and induced by cold treatment. Arch. Biochim. Biophys. 450: 20-29.
- Wansink, B., Westgren, R.E. and Cheney, M.M. 2005. Hierarchy of nutritional knowledge that relates to the consumption of a functional food. Nutrition, 21:2 (February), 264-8.
- Wansink, B. 2005. Marketing Nutrition - Soy, Functional Foods, Biotechnology, and Obesity. Champaign, IL: University of Illinois Press.
- Wansink, B. and Westgren, R. 2003. Profiling taste-motivated segments. Appetite, 41:3 (December), 323-327.
- Wansink, B. and Kim, J. 2001. The marketing and consumer acceptance of biotechnology. Journal of Commercial Biotechnology, (Winter) 7:3, 249-259.
- Wansink, B. 2001. Selling biotechnology? Farmweek, (May 7), 15.
- Wansink, B. and Kim, J. 2001. The marketing battle over genetically modified foods: False assumptions about consumer behavior. American Behavioral Scientist, 44:8 (April), 1405-1417.
- Wu, W.R., Kenzior, A., Wilmot, D., Scanlon, S., Chen, Z., Topin, A., Hua He, S., Acevedo, A. and Folk, W.R . 2007. Altered expression of plant lysyl tRNA synthetase promotes tRNA misacylation and translational recoding of lysine. The Plant Journal 50: 627-636.
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Progress 01/01/06 to 12/31/06
Outputs
The broad goal of the Illinois Missouri Biotechnology Alliance is to strengthen the agriculture and food sectors in the American Midwest, especially the improvement of food safety and quality. The Alliance funds investigator-driven research under two subprograms, one aimed at enhancing profitability and one focused on economics and consumer acceptance. Nine projects were funded by the Illinois-Missouri Biotechnology Alliance in 2006. Detailed information can be found at the program website http://www.imba.missouri.edu/. Project 2006-1: Metabolomic Analysis of Soybean Nematode Interactions: A Prelude to Metabolic Engineering for Nematode Resistance by Kris N. Lambert and Vera Lozovaya, University of Illinois; Project 2006-2: Development of Corn/Soy Plastic Composites: Phase II by Richard C. Larock and Paul W. Gallagher, Department of Chemistry, Iowa State University, Ames, IA; Project 2006-3: Systematically Assigning Gene Functions in Soybean Employing RNAi Technology
by Zhanyuan Zhang, University of Missouri; Project 2006-4: Engineering Soybean for Enhanced Sulfur Amino Acid Content by Hari Krishnan, University of Missouri and Joseph Jez, Donald Danforth Plant Science Center; Project 2006-5: Adaptation of a Gene Switch Technology for use in Soybean Seed by Terry Woodford-Thomas, Donald Danforth Plant Science Center, St. Louis, MO; Project 2006-6: Genomic Evaluation of the Defense Response of Maize Against Herbivory by the Western Corn Rootworm by Martin Bohn, University of Illinois/US; Georgia Davis and Thomas L. Clark, University of Missouri; Project 2006-7: Maximizing the Value of Corn Biotechnologies in Ethanol Production by Nicholas Kalaitzandonakes, University of Missouri and Martha Schlicher, Southern Illinois University-Edwardsville; Project 2006-8: Analytical Tools for Production of Non-Food Protein Corn by Roger Ginder, Corinne Langinier, Darren Jarboe, & Lawrence Johnson, Iowa State University; and Project 2006-9: Innovation & Venture
Formation In Agricultural Biotechnology by Jake Halliday and Nicholas Kalaitzandonakes, University of Missouri.
Impacts
The Illinois-Missouri Biotechnology Alliance (IMBA) is a joint program of the University of Illinois and the University of Missouri [and a partner with Southern Illinois University in Carbondale] and is funded by a Congressional Special Grant administered by the United States Department of Agriculture (USDA). The purpose of IMBA is to fund biotechnology research that is an integral part of a Research and Development (R&D) program directed at expanding the volume of profitable businesses in the United States (U.S.) food and agricultural sector. Initially, the IMBA program was limited in scope to corn and soybeans. However, the scope of IMBA interest now encompasses all concepts of these industries including production, processing, marketing, utilization, inputs and support services, as well as economic, social, environmental, and natural resource concerns. The geographical focus of IMBA is Illinois and Missouri along with other Midwestern states having similar crops,
soils, climate, and socio-economic conditions. IMBA spawned the most read journal on the economics and management of ag biotech - AgBioForum. The electronic journal was read by more than 250,000 unique readers, worldwide, in 2005. One third of the subscribers to ABF are from outside the U.S. and Canada. There has been one start-up company that has developed, based on results of research that was IMBA-supported.
Publications
- Joseph, L.M., Hymowitz, T., Schmidt, M.A. and Herman, E.M. 2006. Evaluation of glycine germplasm for nulls of the immunodominant allergen P34/Gly m Bd 30k. Crop Sci. 2006 46: 1755-1763.
- Kalaitzandonakes, N., Marks, L.A. and Vickner, S.S. 2006. Consumer response to mandated genetically modified foods. In: Paul Weirich (Ed.) Labeling Genetically Modified Food. Oxford University Press [Under Review].
- Kalaitzandonakes, N., Marks, L.A. and Vickner, S.S. 2006. Rejecting conventional wisdom: Market evidence of GM food choices. Science [Under Review].
- Kalaitzandonakes, N., Marks, L.A. and Vicker, S.S. 2004. Media coverage of biotech foods and influence on consumer choice. American Journal of Agricultural Economics 86:1238-1246.
- AbuGhazaleh A., Apgar, G., Buckles, R. and Kalscheur, K. 2005. Production of trans monoenes and conjugated linoleic acid in continuous cultures fed diets containing fish oil and sunflower oil with decreasing levels of forage. J. Anim. Sci. 83:(Suppl 1):181.
- Davis, J., Higginbotham, A., Iqbal, M.J., Moustaid-Moussa, N., O'Connor, T., Shay, N., Adler, S., Peterson, R. and Banz, W.J. 2005. Soy protein and isoflavones influences adiposity and development of metabolic syndrome in the obese male ZDF rat. J. Nutrition [Submitted].
- Cho, K., Banz, W.J., Davis, J. and Kim, Y.C. 2005. Soy isoflavones increase PPAR and GLUT4 gene expression in 3T3-L1 adipocytes and ameliorate the metabolic syndrome in Zucker diabetic fatty rat. J. Nutr. [Under Revision].
- Banz, W.J. 2005. The effect of diet and gender on the development and progression of diabetes and obesity in various preclinical models: Implications for pharmaceutical and nutraceutical research. 2nd Charles River Symposium for Type 2 Diabetes and its Complications.
- Banz, W.J. 2005. The influence of soy consumption on the development and progression of Type 2 diabetes mellitus. Obesity Management: Role of Soy Foods, University of Illinois Research Forum.
- Banz, W.J., Adler, S., Shay, N.F., Ross-Viola, J., Winters, T., Hou, Y. and Meyers, C.Y. 2005. Phytoestrogens and a non-steroidal selective estrogen receptor modulator are also ligands for PPAR-v. The FASEB Journal.
- Adler, S., Banz, W.J., Shay, N.F., Ross-Viola, J., Winters, T., Hou, Y. and Meyers, C.Y. 2005. Phytoestrogens and a non-steroidal selective estrogen receptor modulator are also ligands for PPAR-v. ENDO 2005, The Endocrine Society's 87th Annual Meeting, June 4-7 in San Diego, California.
- Banz, W.J. 2005. The influence of soy consumption on the development and progression of Type 2 diabetes mellitus. Obesity Management: Role of Soy Foods, University of Illinois, Invited Symposium Paper.
- Davis, J., Higginbotham, A., Peterson, R. and Banz, W. 2004. Soy protein influence the development of hypertension and insulin-resistance in male ZDFxSHHF rats. The FASEB Journal.
- Goldsmith, P.D., Turan, N. and Gow, H. 2004. (Micro) Economics of food safety. Presented at the Department of Agricultural and Consumer Economics University of Illinois Seminar Sseries, April, 2004.
- Goldsmith, P.D., Turan, N. and Gow, H. 2004. Firms incentives and the supply of food safety: A formal model of government enforcement. Presented at the Annual Meeting of the American Agricultural Economics Association, Denver, Colorado, August, 2004.
- Matsuno, M., Ralstonm L., Subramanian, S., Walker, L. and Yu, O. 2004. In vivo reconstruction of flavonoid and isoflavonoid biosynthesis in yeast using type I and type II chalcone isomerases from soybean. Invited for oral presentation at the 2004 ASPB Annual Meeting minisymposium-Secondary Metabolism.
- Subramanian, S., Menne, C., Odell, J.T., Stacey, G. and Yu, O. 2004. Isoflavones are essential for the establishment of symbiosis between soybean and Bradyrhizobium japonicum. Invited for oral presentation at the 2004 ASPB Annual Meeting Minisymposium-Symbiosis.
- Wansink, B. and Westgren, R. 2004. When does nutritional knowledge relate to the acceptance of a functional food? University of Illinois Working Paper.
- Balasubramanian, S.K., Moon, W. and Putis, W. 2004. Choice-based conjoint analysis of public perceptions of genetically modified foods. Amsterdam, Netherlands, July 2004.
- Moon, W., Rimal, A. and Balasubramanian, S.K. 2004. Contingent valuation of GM and non-GM foods in the UK: Application of cheap talk script method. Presented at Annual American Agricultural Economics Association Meeting. Denver, CO. Aug 2004.
- Rimal, A., Moon, W. and Balasubramanian, S.K. 2004. An evaluation of consumer acceptance of genetically modified foods: Willingness-to-pay (WTP) vs. willingness-to-accept (WTA). Presented at Southern Agricultural Economics Association Annual Meeting. Tulsa, OK. Feb. 2004.
- Subramanian, S., Matsuno, M., Menne, C., Ralston, L. and Yu, O. 2004. From transcriptional regulation to metabolic channeling: Understanding the flavonoid and isoflavonoid pathway for metabolic engineering. Invited for oral presentation at the Soy 2004 Meeting at Columbia, MO.
- Chema, K., Marks, L.A., Parcell, J. and Bredahl, M. 2006. Marketing biotech functional foods in the US. Canadian Journal of Agricultural Economics [Under Review].
- Qiu, X., Eastridge, M.L., Griswold, K.E. and Firkins, J.K. 2004. Effects of substrate, passage rate, and pH in continuous culture on flows of conjugated linoleic acid and trans C18:1. J. Dairy Sci. 87:3473-3479.
- Matsuno, M., Ralston, L., Subramanian, S., Walker, L. and Yu, O. 2004. Metabolic engineering of phytoestrogenic compounds - isoflavones. Invited for oral presentation at the International Symposium on Profiling and the Use of Plant Metabolites and Medicinal Phytocompounds at Taipei, Taiwan.
- Yu, O. 2004. Metabolic engineering of soybean phytoestrogens. Presented at the International Symposium on Research into Plant Metabolites and Medicinal Phytocompounds. Taipei, Taiwan. Dec 2004.
- Yu, O. 2004. Metabolic regulations of isoflavonoid biosynthsis. Dept. of Biochemistry, Fudan University, Shanghai, China. Dec. 2004.
- Yu, O. 2004. The biological functions of isoflavones during soybean Bradyrhizobium interactions. Inst. Of Botany, Academia Sinica. Dec. 2004.
- Yu, O. 2004. From transcriptional regulation to metabolic channeling: Metabolic engineering of flavonoid and isoflavonoid biosynthesis. Presented at the Soy 2004 Symposium. Columbia, MO. Aug 2004.
- Yu, O. 2004. In vitro reconstruction of flavonoid and isoflavonoid pathway in yeast. Presented at the ASPB Annual Meeting. Orlando, FL. July 2004.
- Yu, O. 2004. Isoflavones are essential during soybean bradyrhizobium interactions. Presented by Senthil Subramanian (postdoc) at ASPB Annual Meeting. Orlando, FL, July 2004.
- Yu, O. 2005. RNAi silencing of soybean defense genes leads to altered responses to elicitors and infection in both transformed and distal tissues. An invited seminar given by Dr. Terry Graham at the joint meeting of MPMI@Ohio (Molecular Plant Microbes at Ohio) and the PMBB (Plant Molecular Biology and Biotechnology) Symposium, April 15, 2005.
- Griswold, K.E., Apgar, G.A., Robinson, R.A., Jacobson, B.N., Johnson, D. and Woody, H.D. 2003. Effectiveness of short-term feeding strategies for altering conjugated linoleic acid (CLA) content of beef. J. Anim. Sci. 81:1862-1871.
- Shay, N. and Banz, W.J. 2005. Regulation of gene transcription by botanicals. Annual Review of Nutrition, Volume 25:297-315.
- Davis, J., Iqbal, M.J., Steinle, J., Oitker, J., Higginbotham, A., Peterson, R. and Banz, W.J. 2005. Soy protein influences the development of the metabolic syndrome in male obese ZDFxSHHF rats. Hormone and Metabolic Research 37:316-325.
- Davis, J., Steinle, J., Higginbotham, A., Oitker, J., Peterson, R. and Banz, W.J. 2005. Soy protein influences insulin-sensitivity and cardiovascular risk in male lean SHHF rats. Hormone and Metabolic Research 37:309-315.
- Ricketts, M., Moore, D., Banz, W., Mezei, O. and Shay, N. 2003. The mechanism of isoflavone action includes activation of PPAR pathways. J. Nutr. Biochem. (Accepted).
- Banz, W.J., Davis J., Peterson, R. and Iqbal, M.J. 2004. Gene expression and adiposity are modified by soy protein in male ZDF rats. Obesity Research 12:1907-1913.
- Jones, K., Harty, J., Roeder, M., Winters, T. and Banz, W. 2004. In vitro effects of soy phytoestrogens on rat L6 skeletal muscle cells. Journal of Medicinal Food. Vol. 8.
- Higginbotham, D.A., Iqbal, M.J., Majewski, H., Davis, J. and Banz, W.J. 2005. A comparison of egg, mik and soy dietary protein in development of obesity in diet induced obese (DIO) and diet resistant (DR) rats. The FASEB Journal.
- Banz, W., Moustaid-Moussa, N., Kim, Y.-C., Cho, K., Shay, N., Higginbotham, A., Davis, J. and Peterson, R. 2004. Soy protein regulates adiposity, insulin-sensitivity and lipogenic capacity in male ZDF rats. The FASEB Journal.
- Rimal, A. and Moon, W. 2005. Agricultural biotechnology and organic food consumption. British Food Journal. Vol 107. No. 2, 2005 (84-96).
- Moon, W. and Balasubramanian, S.K. 2004. Is there a market for GM foods in Europe? Contingent valuation of GM and non-GM breakfast cereals in the UK. AgBioForum, 6 (3), 2004: 128-133.
- Moon, W. and Balasubramanian, S. 2004. Public attitudes toward agrobiotechnology: The mediating role of risk perceptions on the impact of trust, awareness and outrage. Review of Agricultural Economics, vol 26 No. 2, 2004: 186-208.
- Turan, N.A. and Goldsmith, P.D. 2005. Legal systems, institutional environment, and food safety. Agricultural Economics [Under Review].
- Turan, N. and Goldsmith, P.D. 2005. Governments and firms: Incentives to supply safe food. Food Policy [Under Review].
- Goldsmith, P.D., Turan, N. and Gow, H.R. 2003. Food safety in the meat industry: A regulatory quagmire. International Food and Agribusiness Management Review. 6(1) 2003.
- Sporleder, T.L. and Goldsmith, P.D. 2001. Alternative firm strategies for signaling quality in the food system. Canadian Journal of Agricultural Economics 49 (4) 2001: 591-604.
- Wansink, B. 2004. Marketing nutrition: Soy, functional foods, biotechnology, and obesity. Champaign, IL: University of Illinois Press.
- Wansink, B. 2004. Consumer reactions to food safety crises, advances in food and nutrition research [Forthcoming].
- Ralston, L., Subramanian, S., Matsuno, M. and Yu, O. 2005. Partial reconstruction of flavonoid and isoflavonoid biosynthesis in yeast (Saccharomyces cerevisiae) using soybean type I and type II chalcone isomerases. Plant Physiology 137: 1375-1388.
- Subramainan, S., Graham, M.L., Yu, O. and Graham, T. 2005. Silencing of soybean isoflavone synthase through an RNAi approach leads to silencing in non-transformed tissue and to enhanced susceptibility to Phytophthora sojae. Plant Physiology 137: 1345-1353.
- Yu, O. and McGonigle, B. 2005. Metabolic engineering of isoflavone biosynthesis. Advances in Agronomy 86: 147-189.
- Bennett, J.O., Yu, O., Heartherly, L.G. and Krishnan, H.B. 2004. Accumulation of genistein and daidzein, soybean isoflavones implicated in promoting human health, is significantly elevated by irrigation. Journal of Agricultural and Food Chemistry 52: 7574-7579.
- Subramanian, S., Xu, L., Lu, G., Odell, J. and Yu, O. 2004. The promoters of the isoflavone synthase genes respond differentially to nodulation and defense signals in transgenic soybean roots. Plant Molecular Biology 54:226-239.
- Ralston, L. and Yu, O. 2003. [Patent] In vivo reconstruction of the flavonoid and isoflavonoid pathway. Technology Disclosure from the Donald Danforth Plant Science Center.
- Kalaitzandonakes, N. and Kaufman, J. 2006. GM crops impact starch industry. Grain World, February 2006.
- Chema, S.K. 2004. Marketing of biotech functional foods in the U.S. MSc. Thesis, Department of Agricultural Economics, Univeristy of Missouri, Columbia, Missouri.
- Chema, K., Marks, L.A., Parcell, J. and Bredahl, M. 2004. Marketing biotech functional foods in the U.S. Selected paper presented at the American Agricultural Economics Association Annual Meetings, July 31st to August 4th, Colorado.
- Kalaitzandonakes, N., Marks, L.A. and Vickner, S.S. 2005. Market evidence of consumer response to mandated genetically modified food labels. Invited paper presented at Labeling Genetically Modified Food: an Interdisciplinary Conference at the University of Missouri-Columbia, Columbia Missouri, November 4-5, 2005.
- Xiaohong, L., Jamai, A., Meksem, K. and Mitchum, M.G. 2005. Elucidating the molecular mechanism of soybean resistance to soybean cyst nematode. MU Life Sciences Week 2005, Poster Presentation.
- AbuGhazaleh, A., Apgar, G. and Jacobson, B. 2005. The effect of docosahexaenoic acid on the production of vaccenic acid and conjugated linoleic acid from unsaturated C18 fatty acids in rumen cultures. J. Anim. Sci. 83(Suppl. 1):180.
- AbuGhazaleh, A., Apgar, G. and Jacobson, B. 2005. The effect of low pH on the production of trans monoenes and conjugated linoleic acid in rumen cultures containing docosahexaenoic acid and unsaturated 18 carbons fatty acids. J. Anim. Sci. 83(Suppl. 1):180.
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Progress 01/01/05 to 12/31/05
Outputs
The broad goal of the Illinois Missouri Biotechnology Alliance is to strengthen the agriculture and food sectors in the American Midwest, especially the improvement of food safety and quality. The Alliance funds investigator-driven research under two subprograms, one aimed at enhancing profitability and one focused on economics and consumer acceptance. Nine projects were funded by the Illinois-Missouri Biotechnology Alliance in 2005. Detailed information can be found at the program website http://www.imba.missouri.edu/. (1) Genetic Enhancement Of The Antioxidant Content Of Soybean Oil For Improved Food Processing, Lubricant And Nutriceutical Properties. (2) Identification Of Key Defense Genes For Resistance To Phytopthora Stem And Root Rot Through Gene Silencing. (3) Developing Targeted Resistance To Soybean Cyst Nematode In Soybean. (4) Breeding For Enhanced Molecular Farming In Maize Seeds. (5) Development Of Corn/Soy Plastic Composites. (6) Compliance Costs Of
Regulation In The Development Of Differentiated Product Channels. (7) Agricultural Biotechnology, CAFTA, And The Development Of Differentiated Product Channels. (8) Novel Crop Biotechnologies And The United States Ethanol Industry. (9) Evaluating The Outcomes Of IMBA Research. Four projects have been funded so far by the Illinois-Missouri Biotechnology Alliance in 2006. (1) Development Of Corn/Soy Plastic Composites: Phase II. (2) Adaptation Of A Gene Switch Technology For Use In Soybean Seed. (3) Maximizing The Value Of Corn Biotechnologies In Ethanol Production. (4) Analytical Tools For Production Of Non-Food Protein Corn.
Impacts
The Illinois-Missouri Biotechnology Alliance (IMBA) is a joint program of the University of Illinois and the University of Missouri and is funded by a Congressional Special Grant administered by the United States Department of Agriculture (USDA). The purpose of IMBA is to fund biotechnology research that is an integral part of a Research and Development (R&D) program directed at expanding the volume of profitable businesses in the United States (U.S.) food and agricultural sector. Initially, the IMBA program was limited in scope to corn and soybeans. However, the scope of IMBA interest now encompasses all concepts of these industries including production, processing, marketing, utilization, inputs and support services, as well as economic, social, environmental, and natural resource concerns. The geographical focus of IMBA is Illinois and Missouri along with other Midwestern states having similar crops, soils, climate, and socio-economic conditions.
Publications
- Davis, J., Higginbotham, A., Iqbal, M.J., Moustaid -Moussa, N., O'Connor, T., Shay, N., Adler, S., Peterson, R. and Banz, W.J. 2005. Soy protein and isoflavones influences adiposity and development of metabolic syndrome in the obese male ZDF rat. J. Nutrition (Submitted).
- Cho, K., Banz, W.J., Davis, J. and Kim, Y.C. 2005. Soy isoflavones increase PPAR and GLUT4 gene expression in 3T3-L1 adipocytes and ameliorate the metabolic syndrome in Zucker Diabetic Fatty rat. J. Nutrition (Under Revision).
- Shay, N. and Banz, W.J. 2005. Regulation of gene transcription by botanicals. Annual Review of Nutrition Volume 25:297-315.
- Davis, J., Iqbal, M.J., Steinle, J., Oitker, J., Higginbotham, A., Peterson, R. and Banz, W.J. 2005. Soy protein influences the development of the metabolic syndrome in male obese ZDF x SHHF rats. Hormone and Metabolic Research 37:316-325.
- Davis, J., Steinle, J., Higginbotham, A., Oitker, J., Peterson, R. and Banz, W.J. 2005. Soy protein influences insulin-sensitivity and cardiovascular risk in male lean SHHF rats. Hormone and Metabolic Research 37:309-315.
- Ralston, L. Subramanian, S., Matsuno, M. and Yu, O. 2005 . Partial reconstruction of flavonoid and isoflavonoid biosynthesis in yeast (Saccharomyces cerevisiae) using soybean type I and type II chalcone isomerases. Plant Physiology 137: 1375-1388.
- Subramainan, S., Graham, M.L., Yu, O. and Graham, T. 2005. Silencing of soybean isoflavone synthase through an RNAi approach leads to silencing in non-transformed tissue and to enhanced susceptibility to Phytophthora sojae. Plant Physiology 137: 1345-1353.
- Yu, O. and McGonigle, B. 2005. Metabolic engineering of isoflavone biosynthesis. Advances in Agronomy 86: 147-189.
- Ralston, L. and Yu, O. 2003. In vivo reconstruction of the flavonoid and isoflavonoid pathway. Technology Disclosure from the Donald Danforth Plant Science Center.
- English, J.T. and Schmidt, F.J. 2004. Phage Display Selection of Antifungal Peptides (US Patent Application serial no. 09/829,549).
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