Source: UNIVERSITY OF CALIFORNIA, DAVIS submitted to
DEVELOPMENT OF THE WESTERN INSTITUTE FOR FOOD SAFETY AND SECURITY (WIFSS)
Sponsoring Institution
Cooperating Schools of Veterinary Medicine
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0198840
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
Sep 1, 2002
Project End Date
Jun 30, 2012
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
UNIVERSITY OF CALIFORNIA, DAVIS
410 MRAK HALL
DAVIS,CA 95616-8671
Performing Department
Pathology, Microbiology & Immunology
Non Technical Summary
California consumers and food and agricultural industries are at an increased risk for foodborne illness outbreaks and food product recalls. Additionaly, there is increased risk of bioterrorism and a need to strenghten homeland security protection relating to food and agriculture. The Western Institute for Food Safety and Security (WIFSS) will support improved food safety and protection activities for Californias food supply with enormous health benefits for residents and positive economic consequences for the States food industry.
Animal Health Component
(N/A)
Research Effort Categories
Basic
(N/A)
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
7113910109015%
7113910117015%
7115010109010%
7115010117010%
7123910109015%
7123910117015%
7125010109010%
7125010117010%
Goals / Objectives
The Institutes primary mission is to ensure the safety of the States food by meeting the goals of 1) developing the capability to identify foodborne hazards more rapidly and accurately and 2) developing effective interventions to prevent natural and intentional food contamination that may lead to foodborne illnesses and outbreaks. The Institute will support partnerships, research, and technology required for science-based food safety policy.
Project Methods
The newly established Western Institute for Food Safety and Security is a collaborative effort among the University of California, Davis (UCD), the California Department of Food and Agriculture (CDFA), the California Department of Health Services (DHS), and the States food and agricultural industry. A dedicated facility has been constructed at UCD with research laboratories, meeting rooms, a conference center, classrooms, and offices. The Institute is dedicated to applied food safety research. All university programs associated with food safety will be represented in the Institute. The top food safety scientists from DHS and CDFA will identify the most important current food safety issues and work together with academia to conduct applied research on these issues. Research at the Institute will lead to improved communication, cooperation, and collaboration among government agencies, food industries, academia and consumers. Specific areas of research will include: Rapid diagnostics of disease agents, Microbial Safety of Fruits, Vegetables and Nuts, Safe Disposal and Alternative Uses of Animal Mortality and Manure , Bioterrorism: Develop Methods to Enhance Biosecurity and Improve Training, Enhancement of Post-harvest Pasteurization Processes, Risk Assessment, Antimicrobial Resistance Issues, Biotechnology.

Progress 10/01/11 to 06/30/12

Outputs
Target Audience: Nothing Reported Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? Progress report was submitted to the funding agency.

Publications


    Progress 09/01/02 to 06/30/12

    Outputs
    Target Audience: Nothing Reported Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

    Impacts
    What was accomplished under these goals? Final Report was submitted to the funding agency

    Publications


      Progress 10/01/10 to 09/30/11

      Outputs
      Target Audience: Nothing Reported Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

      Impacts
      What was accomplished under these goals? Progress report was submitted to the Funding agency.

      Publications


        Progress 10/01/09 to 09/30/10

        Outputs
        Target Audience: Nothing Reported Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

        Impacts
        What was accomplished under these goals? Progress Report submitted to the funding agency.

        Publications


          Progress 10/01/08 to 09/30/09

          Outputs
          Target Audience:Progress reports for this project were submitted to the Sponsoring Agency Changes/Problems:Progress reports for this project were submitted to the Sponsoring Agency What opportunities for training and professional development has the project provided?Progress reports for this project were submitted to the Sponsoring Agency How have the results been disseminated to communities of interest?Progress reports for this project were submitted to the Sponsoring Agency What do you plan to do during the next reporting period to accomplish the goals?Progress reports for this project were submitted to the Sponsoring Agency

          Impacts
          What was accomplished under these goals? Progress reports for this project were submitted to the Sponsoring Agency

          Publications


            Progress 01/01/08 to 09/30/08

            Outputs
            Target Audience: Nothing Reported Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

            Impacts
            What was accomplished under these goals? Progress Reports submitted to the funding agency according to agreement.

            Publications


              Progress 01/01/07 to 12/31/07

              Outputs
              The Western Institute for Food Safety and Security has forged many collaborative partnerships with agencies and individuals who would like to partner with WIFSS in its mission to facilitate solutions to our nation's food safety challenges. As we continue to learn about the breadth and complexity of our food production, processing, and distribution systems, it becomes increasingly clear that the enterprise of producing food has a large and influential role in shaping our society, our health, and the environment in which we live. Microbial and chemical threats to food safety continue to challenge the many segments of our food supply, underscoring the need for excellence in research, effective outreach, and an abiding commitment to develop comprehensive solutions that promote a safe, wholesome and reliable food supply.

              Impacts
              WIFSS has created many innovative programs, new initiatives, outreach efforts, and supported new research programs in the area of food safety and security.

              Publications

              • No publications reported this period


              Progress 01/01/06 to 12/31/06

              Outputs
              WIFSS continues to grow and meet is mission statement through the following four major programs: 1) California Department of Food and Agriculture (CDFA) contract has provided core funding for WIFSS. The request for extension without new funds was approved June 2006. This funding provides salary for WIFSS scientists/laboratory and is critical to sustaining the WIFSS research agenda. WIFSS laboratory is a multidisciplinary group of scientists working on a wide range of issues related to food safety and food security. The following are examples of the broad types of research being conducted by WIFSS scientists with the long term goal of reducing illness associated with the consumption of food; tracking and controlling the bacteria E. coli O157:H7 from the farm to the table; unraveling how the E. coli O157:H7 bacterial cell controls its potentially deadly toxins; using DNA fingerprinting to better understand Campylobacter infections in humans and animals; agroterrorism and the dairy farmer; perchlorate: what is the human health risk from this rocket fuel by-product? As a subset of the CDFA contract, WIFSS has awarded approximately $650,000 in competitive research grants to investigators on the UCD campus. 2) DHS-ODP Training Grant to Enhance Prevention, Deterrence, Response and Recovery from WMD Incidents in California Dairy and Processed Produce Systems. While making very substantial progress on the objectives of this training grant, this funding has been essential to the Institutes infrastructure. It has provided approximately 50% of the salaries for the Institutes staff and 55% of the infrastructure support for the Institute. It has provided for growth in the institute and continued funding will enable the Institute to make progress on its three missions; research, outreach and information management. 3) FDA/CDC California Food Safety and Security Agency Team Conference is an ongoing program in which WIFSS organizes food safety workers from across the state for quarterly videoconference meetings. This program draws approximately 100 persons together to discuss advances in food safety and food defense and to interact on shared challenges in the food systems. 4) FDA Center of Excellence has been a 4-year effort to establish an FDA Western Center for Food Safety and Food Defense within WIFSS. The only mode to accomplish this is to have it mandated by the US Congress. This has involved a major effort by the WIFSS staff to develop the necessary advocacy by private industry, governmental agencies and UCD to persuade Congress to fund the Center. Although each year we have made progress, to date, we have not yet had both Senate and House approval of the initiative. We have recently been told that we do now have both and the Center is expected to become a reality this fall.

              Impacts
              WIFSS was established by the UCD School of Veterinary Medicine and is affiliated with the California Department of Food and Agriculture and with the California Department of Health Services. The mission of WIFSS is to enhance research, education, and outreach in food safety and security for the betterment of the food industry, public health, and national security.

              Publications

              • Li, H. and O Sullivan, D.J. 2006. Identification of an internal promoter nisI within nisABTCIP operon that enables establishment of the nisin immunity prior to induction of the operon via the signal transduction. J. Bacteriol. 188(24):8496-8503.
              • Sudarshana, M.R., Roy, G., and Falk, B.W. 2006. Methods for engineering resistance to plant viruses. In: Plant-Pathogen Interactions, Methods and Protocols (Ronald .P.C. ed) Methods in Molecular Biology. 354:183-196.
              • Roy, G., Sudarshana, M.R. Ullman, D.E., Ding, S.-W., Dandekar, A.M., and Falk, B.W. 2006. Chimeric cDNA Sequences from Citrus tristeza virus confer RNA silencing-mediated resistance in transgenic Nicotiana benthamiana plants. Phytopathology 96:819-827.
              • Sudarshana, M.R., Plesha, M.A., Uratsu, S.L., Falk, B.W., Dandekar, A.M., Huang, T.K., and McDonald, K.A. 2006. A Chemically inducible cucumber mosaic virus amplicon system for expression of heterologous proteins in plant tissues. Plant Biotechnology Journal. 4:551-559.


              Progress 01/01/05 to 12/31/05

              Outputs
              WIFSS continued to lead the effort on the following five projects: 1) California Department of Food and Agriculture contract has provided core funding for WIFSS, and the extension will provide approximately $1.5 million funding for the period June 2005 to July 2006. This allocation will provide salary for personnel and facilities support for the Institute. The request for extension without new funds is expected to be approved March 2006. This funding provides salary for WIFSS scientists and is critical to sustaining the WIFSS research agenda. As a subset of this contract, WIFSS has awarded approximately $650,000 in competitive research grants to investigators on the UCD campus. This has resulted in an expansion of the research capacity of the Institute. 2) DHS-ODP Training Grant to Enhance Prevention, Deterrence, Response and Recovery from WMD Incidents in California Dairy and Processed Produce Systems. While making very substantial progress on the objectives of this training grant, this funding has been essential to the Institutes infrastructure. It has provided approximately 50% of the salaries for the Institutes staff and 55% of the infrastructure support for the Institute. It has provided for growth in the institute and continued funding will enable the Institute to make progress on its three missions; research, outreach and information management. 3) CDFA Agro-terrorism Prevention: Critical Food Supply Infrastructure Identification, Systems Analysis, Threat Assessment and Protection; This project provided valuable information for the dairy industry as it attempts to improve security measures to forestall agroterrorism and other disaster events on their premises. This information is being integrated into the WIFSS DHS-Agroterrorism Preparedness Curriculum for community disaster responders. 4) FDA/CDC California Food Safety and Security Agency Team Conference is an ongoing program in which WIFSS organizes food safety workers from across the state for quarterly videoconference meetings. This program draws approximately 100 persons together to discuss advances in food safety and food defense and to interact on shared challenges in the food systems. 5) FDA Center of Excellence has been a 3 year effort to establish an FDA Western Center for Food Safety and Food Defense within WIFSS. The only mode to accomplish this is to have it mandated by the US Congress. This has involved a major effort by the WIFSS staff to develop the necessary advocacy by private industry, governmental agencies and UCD to persuade Congress to fund the Center. Although each year we have made progress, to date, we have not yet had both Senate and House approval of the initiative.

              Impacts
              WIFSS was established by the UCD School of Veterinary Medicine and is affiliated with the California Department of Food and Agriculture and with the California Department of Health Services. The mission of WIFSS is to enhance research, education, and outreach in food safety and security for the betterment of the food industry, public health, and national security.

              Publications

              • Gillespie, JR; 2005, Training the local community in food security awareness, Journal of the Association of Food and Drug Officials, p 26.


              Progress 01/01/04 to 12/31/04

              Outputs
              WIFSS led the effort on the following extramural grants: DHS-ODP Training to Enhance Prevention, Deterrence, Response and Recovery from WMD Incidents in Calif Dairy and Processed Produce Systems ($4.7 m 2 yrs funded); CDFA Agro-terrorism Prevention: Critical Food Supply Infrastructure Identification, Systems Analysis, Threat Assessment and Protection ($400,000 funded); FDA/CDC Calif Food Safety and Security Agency Team Conference ($21,000 funded), CDHS Team Building to Prepare for Public Health Emergencies ($2.4 m pending); FDA Center of Excellence ($2,857,000 pending). WIFSS personnel includes staff/ scientists paid by WIFSS, personnel from CDFA/CDHS and affiliate scientists (appointments in other departments). A main focus has been research efforts in WIFSS laboratory. M. Jay, E. Shiilegdamba and K. McGarvey are investigating the cause of E. coli 0157:H7 contamination in lettuce. M. Sudarshana is studying food safety/security issues in plant-food systems and toxicity of Perchlorate in food and water. H. Li is studying pathogenicity of foodborne pathogens in different environments to see if food-system practices are leading to an evolution of greater numbers of foodborne microbial pathogens. WIFSS laboratory development plans changed this year due to insufficient funds for development. WIFSS scientists are working in space made available by the SVM in Haring Hall. WIFSS website is continually improving and expanding adding food safety alerts (latest on food borne disease information-science, outbreaks, strategies to deal with agro-terrorism); presentations made by WIFSS scientists; the DHS/ODP-Training Grant. WIFSS announced the 2004/05 WIFSS Research Proposal awards Sept 2004. WIFSS is organizing an Antimicrobial Resistance National Conference-Fall 2005. The Director has been working with the Board on strategies to continue funding that include the following: allocations of fed formula funding from DHS and/or DHHS; renewal of CDFA contract; renewal of CDHS funds; seeking extramural funds from: USDA, USDHHS-NIH, -FDA, -CDC, DHS, DOD, other agencies and private sources. WIFSS continues to move forward on a FDA Center of Excellence to deal with food safety and security issues. The Institute is continuing to seek transfer of the Western USDA-FSIS laboratory from Alameda to WIFSS/Davis. The greatest challenges for WIFSS are developing a new funding stream prior to the termination of the current CDFA contract and that WIFSS is handicapped in its efforts to recruit scientists and compete for extramural research funding because it lacks research facilities. WIFSS success stories include WIFSS filling out its core staff and strengthening its research capabilities. WIFSS received a number of extramural grants last year. WIFSS has built a wide spectrum of partnerships, including local, state and federal governmental agencies; private entities; and research groups within and outside academia. These partnerships are being expanded by work underway on the DHS/ODP-Training Grant. The Director has increased his presentations to a number of organizations nationwide. WIFSS has developed a series of strategies to sustain and enhance funding for the Institute.

              Impacts
              WIFSS was established by the UCD School of Veterinary Medicine and is affiliated with the California Department of Food and Agriculture and with the California Department of Health Services. The mission of WIFSS is to enhance research, education, and outreach in food safety and security for the betterment of the food industry, public health, and national security.

              Publications

              • Gillespie, JR; 2004, Systems Framework for Livestock Research, Receptors, End-Users and Providers, Livestock Development Group, p 93-95.


              Progress 01/01/03 to 12/31/03

              Outputs
              USDA formula (1433) funds designated for research in food safety and assigned to the Western Institute for Food Safety and Security (WIFSS) were used to purchase necessary start-up equipment for the WIFSS laboratory. WIFSS is a new institute that was created by the School of Veterinary Medicine at the University of California, Davis, in partnership with the California Department of Food and Agriculture and the California Department of Health Services. These Departments and the School of Veterinary Medicine provided funding for the basic infrastructure (e.g., leased office and laboratory space, building operating expenses, and salary support). No funding was provided for essential laboratory equipment. The equipment that was purchased with USDA funds will provide the research scientists at WIFSS with the necessary equipment to conduct food safety research. One aspect of that research will focus on understanding the conditions under which highly virulent strains of foodborne bacteria emerge. Dr. Galland, who recently joined the WIFSS staff from Kansas State University, will be using the equipment to continue research begun there and already has submitted a proposal to USDA to fund a research project on livestock lagoons as a source for emergence and spread of antibiotic resistance foodborne bacteria. Dr. Michelle Jay-Russell, who is a new research scientist at WIFSS from the California Department of Health Services, has research just underway on the factors associated with the spread of pathogens in food crops and has submitted a proposal to USDA to help fund that research. Several searches for positions are underway for an additional WIFSS scientist and for postdoctoral fellows, who also will require use of the equipment purchased. That equipment includes basic, but costly, laboratory equipment such as freezers, centrifuges, and incubators; and specialized equipment such as real-time PCR and PFGE equipment. Since our last report, which included the formation of the Institute, all the equipment has arrived and is being set up, the required initial quality control procedures are being carried out, and personnel are being trained. We expect the laboratory to be fully operational by July 31, 2004. The expenditure of these funds have enabled us to recruit faculty that specialize in food safety; has enabled new faculty at WIFSS to establish collaborations with other food safety faculty based on the availability of the equipment, and has enabled us to have the necessary equipment to seek extramural funding, including funding from other USDA sources, for food safety research and outreach. These important outcomes otherwise would not have been possible.

              Impacts
              WIFSS was established by the UCD School of Veterinary Medicine and is affiliated with the California Department of Food and Agriculture and with the California Department of Health Services. The mission of WIFSS is to enhance research, education, and outreach in food safety and security for the betterment of the food industry, public health, and national security.

              Publications

              • No publications reported this period