Recipient Organization
AUBURN UNIVERSITY
108 M. WHITE SMITH HALL
AUBURN,AL 36849
Performing Department
COLLEGE OF VETERINARY MEDICINE
Non Technical Summary
Not knowing correct milk withdrawal of the anesthetics can result in consumption of milk containing anesthetic residue which may greatly affects human health. Milk withdrawal time of the anesthetic can be determined based on the disappearance time of the anesthetics from the blood and the milk. The result of this project, thus, can be used to prevent anesthetic residue in the milk.
Animal Health Component
100%
Research Effort Categories
Basic
(N/A)
Applied
100%
Developmental
(N/A)
Goals / Objectives
The goals of this project are to measure the concentrations of commonly used anesthetics and anesthetic adjuncts (xylazine, butorphanol, ketamine, propofol, guaifenesin,lidocaine, tolazoline, and yohimbine) in milk over times and hence determine actual milk withdrawal times of these drugs when administered to dairy cows.
Project Methods
Nine dairy cows and nine anesthetic treatments will be studied in this projects. Cows will be randomly assigned to each treatment with at least a one-week interval between treatments. Ten milliliters each of milk and venous blood samples will be collected prior to and at 5, 10, 20, 30, 40, 50, and 60 minutes and at 2, 4, 6, 8, 10, 12, 24, 48, 72, 96 and 120 hours after anesthetic administration to determine anesthetic concentration over times. High performance liquid chromatography (HPLC) will be used for assay of anesthetic concentrations.