Source: WINONA STATE UNIVERSITY submitted to NRP
ACUTE AND CHRONIC EFFECTS OF CRANBERRY JUICE CONSUMPTION ON CORONARY HEART DISEASE RISK FACTORS
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
NRI COMPETITIVE GRANT
Reporting Frequency
Annual
Accession No.
0195516
Grant No.
2001-35201-13139
Cumulative Award Amt.
$45,589.00
Proposal No.
2003-04249
Multistate No.
(N/A)
Project Start Date
Jul 1, 2002
Project End Date
Jun 30, 2005
Grant Year
2003
Program Code
[80.3]- (N/A)
Recipient Organization
WINONA STATE UNIVERSITY
(N/A)
WINONA,MN 55987
Performing Department
(N/A)
Non Technical Summary
Coronary heart disease is a major cause of human death. This project will determine if the consumption of cranberry juice can reduce the risk factors associated with the development of heart disease. Specific risk factors studied include improvement of blood flow in the arm and heart, reductions in blood clotting, and improved blood antioxidant levels in the blood.
Animal Health Component
80%
Research Effort Categories
Basic
(N/A)
Applied
80%
Developmental
20%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
7021121101050%
7021121102050%
Knowledge Area
702 - Requirements and Function of Nutrients and Other Food Components;

Subject Of Investigation
1121 - Cranberry;

Field Of Science
1010 - Nutrition and metabolism; 1020 - Physiology;
Goals / Objectives
The working hypothesis is that human cranberry juice (CBJ) consumption can create beneficial acute and chronic changes in antioxidant capacity, platelet aggregation and vasodilatory status in a manner similar to cardiovascular disease (CVD) effects associated with red wine and the French Paradox. Study I: Changes in CVD risk factors during the six hours following consumption: Completed 2001/2002. Study II: Changes in CVD risk factors during 8 weeks of consumption: Complete 2003/2004. Does antioxidant capacity increase? Does platelet aggregation decrease? Does a dose/response effect exist? Study III: CBJ consumption and changes in angiographic/Doppler flow analysis: Complete 2003/2004.
Project Methods
Part of the acute studies of this project have been completed (Study 1), the Doppler/Ultrasound measurement of blood flow and dilation in coronary artery of the heart (invasive measurement) remains to be completed (Study 2). The study population in these studies will be persons with pre-existing cardiovascular disease. Chronic CBJ effects on cardiovascular risk factor modification will also be analyzed (Study 3). Antioxidant activity will be evaluated by using the FRAP assay, LDL oxidation tests, and isoprostane analysis. Effects on plasma insulin, lipid, and nitric oxide levels will be enzymatically evaluated. Finally, platelet aggregometry will be used to evaluate CBJ-dependent blood clotting effects. The population used for this study will be persons receiving a clinically prescribed angiogram/intracoronary blood flow analysis.

Progress 10/01/02 to 09/30/03

Outputs
Work will continue in 2004

Impacts
Improved public understanding of cranberry health benefits.

Publications

  • Wilson, T. Cranberry Juice Effects on Health. In: Beverages in Health and Nutrition. T. Wilson and N.J. Temple (eds). Humana Press, Totowa, NJ, 2003, pp51-61.