Source: UNIVERSITY OF ILLINOIS submitted to
ILLINOIS-MISSOURI ALLIANCE FOR BIOTECHNOLOGY
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
TERMINATED
Funding Source
SPECIAL GRANT
Reporting Frequency
Annual
Accession No.
0195126
Grant No.
2003-34346-13070
Project No.
ILLU-483-640
Proposal No.
2003-06083
Multistate No.
(N/A)
Program Code
KM
Project Start Date
Jul 1, 2003
Project End Date
Jun 30, 2006
Grant Year
2003
Project Director
Pueppke, S. G.
Recipient Organization
UNIVERSITY OF ILLINOIS
2001 S. Lincoln Ave.
URBANA,IL 61801
Performing Department
UNIVERSITY ADMINISTRATION
Non Technical Summary
For additional information on the Illinois-Missouri Biotechnology Alliance please consult our website at www.imba.missouri.edu
Animal Health Component
(N/A)
Research Effort Categories
Basic
100%
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
5021510108025%
5021820108025%
6041510301025%
6041820301025%
Knowledge Area
502 - New and Improved Food Products; 604 - Marketing and Distribution Practices;

Subject Of Investigation
1510 - Corn; 1820 - Soybean;

Field Of Science
1080 - Genetics; 3010 - Economics;
Goals / Objectives
The Illinois-Missouri Biotechnology Alliance (IMBA) enhances the profitability of the American agriculture and food sector by improving the quality, safety, and affordability of agricultural and food products. Research under the Enhanced Profitability Program seeks to: (1) Develop new and improved uses for corn and soybeans; (2) Increase the value of these crops as raw materal for manufacturing; (3) Lower the cost of producing, processing, and utilizing these products; (4) Maximize positive and minimize negative impacts of the corn and soybean industries on the environment; and (5) Conserve nonrenewable resources that are consumed by the corn and soybean industries. The second IMBA objective is to maximize the benefits of agricultural biotechnology for the domestic agricultural and food sectors and ultimately the American public. The Socioeconomic Research Program seeks to: (1) Anticipate and understand the economic and socal impacts of agricultural biotechnology; (2) Capture as many of these benefits as possible for the American agriculture and food sector, especially that in the Midwest; (3) Define the roles of experts and knowledge systems in resolving social conflicts over agricultural biotechnology; (4) Sort out the economic, organizational, and institutional dimensions of value-enhancement and identity preservation; and (5) Understand and manage agricultural biotechnology risks as perceived by consumers.
Project Methods
This section describes management policies for IMBA and its two subprograms. In both cases, specific research proposals will be solicited from scientists and then evaluated. In general, IMBA will accomplish its objectives by supporting cutting edge, strategically directed research that addresses clearly defined objectives that serve the overall mission of the program. The subject matter scope of IMBA research programs is focused on corn and soybean, but it encompasses all aspects of these industries - production, processing, marketing, utilization, inputs, and support services. Economic and socal issues raised by the application of biotechnology to the agriculture and food sectors are included. IMBA is limited geographically to Illinois, Missouri, and other midwestern states with similar crops, soils, climate, and socio-economic conditions. But it may elect to fund proposals from outside this region when necessary to enlist the best scientific talent to address key issues of programmatic concern. The use of federal funds appropriated for IMBA will be limited to broadly defined biotechnology investigations including those that evaluate the technical, social, and economic potential of materials and systems generated by such investigations. Funds for IMBA that are appropriated as a USDA Special Grant shall be used only to pay the direct costs of research by qualified scientists from nonprofit institutions, as well as any direct costs of administering the program.

Progress 07/01/03 to 06/30/06

Outputs
The broad goal of the Illinois Missouri Biotechnology Alliance is to strengthen the agriculture and food sectors in the American Midwest, especially the improvement of food safety and quality. The Alliance funds investigator-driven research under two subprograms, one aimed at enhancing profitability and one focused on economics and consumer acceptance. Nine projects were funded by the Illinois-Missouri Biotechnology Alliance in 2006. Detailed information can be found at the program website http://www.imba.missouri.edu/. Project 2006-1: Metabolomic Analysis of Soybean Nematode Interactions: A Prelude to Metabolic Engineering for Nematode Resistance by Kris N. Lambert and Vera Lozovaya, University of Illinois; Project 2006-2: Development of Corn/Soy Plastic Composites: Phase II by Richard C. Larock and Paul W. Gallagher, Department of Chemistry, Iowa State University, Ames, IA; Project 2006-3: Systematically Assigning Gene Functions in Soybean Employing RNAi Technology by Zhanyuan Zhang, University of Missouri; Project 2006-4: Engineering Soybean for Enhanced Sulfur Amino Acid Content by Hari Krishnan, University of Missouri and Joseph Jez, Donald Danforth Plant Science Center; Project 2006-5: Adaptation of a Gene Switch Technology for use in Soybean Seed by Terry Woodford-Thomas, Donald Danforth Plant Science Center, St. Louis, MO; Project 2006-6: Genomic Evaluation of the Defense Response of Maize Against Herbivory by the Western Corn Rootworm by Martin Bohn, University of Illinois/US; Georgia Davis and Thomas L. Clark, University of Missouri; Project 2006-7: Maximizing the Value of Corn Biotechnologies in Ethanol Production by Nicholas Kalaitzandonakes, University of Missouri and Martha Schlicher, Southern Illinois University-Edwardsville; Project 2006-8: Analytical Tools for Production of Non-Food Protein Corn by Roger Ginder, Corinne Langinier, Darren Jarboe, & Lawrence Johnson, Iowa State University; and Project 2006-9: Innovation & Venture Formation In Agricultural Biotechnology by Jake Halliday and Nicholas Kalaitzandonakes, University of Missouri.

Impacts
The Illinois-Missouri Biotechnology Alliance (IMBA) is a joint program of the University of Illinois and the University of Missouri [and a partner with Southern Illinois University in Carbondale] and is funded by a Congressional Special Grant administered by the United States Department of Agriculture (USDA). The purpose of IMBA is to fund biotechnology research that is an integral part of a Research and Development (R&D) program directed at expanding the volume of profitable businesses in the United States (U.S.) food and agricultural sector. Initially, the IMBA program was limited in scope to corn and soybeans. However, the scope of IMBA interest now encompasses all concepts of these industries including production, processing, marketing, utilization, inputs and support services, as well as economic, social, environmental, and natural resource concerns. The geographical focus of IMBA is Illinois and Missouri along with other Midwestern states having similar crops, soils, climate, and socio-economic conditions. IMBA spawned the most read journal on the economics and management of ag biotech - AgBioForum. The electronic journal was read by more than 250,000 unique readers, worldwide, in 2005. One third of the subscribers to ABF are from outside the U.S. and Canada. There has been one start-up company that has developed, based on results of research that was IMBA-supported.

Publications

  • Joseph, L.M., Hymowitz, T., Schmidt, M.A. and Herman, E.M. 2006. Evaluation of glycine germplasm for nulls of the immunodominant allergen P34/Gly m Bd 30k. Crop Sci. 2006 46: 1755-1763.
  • Kalaitzandonakes, N., Marks, L.A. and Vickner, S.S. 2006. Consumer response to mandated genetically modified foods. In: Paul Weirich (Ed.) Labeling Genetically Modified Food. Oxford University Press [Under Review].
  • Kalaitzandonakes, N., Marks, L.A. and Vickner, S.S. 2006. Rejecting conventional wisdom: Market evidence of GM food choices. Science [Under Review].
  • Kalaitzandonakes, N., Marks, L.A. and Vicker, S.S. 2004. Media coverage of biotech foods and influence on consumer choice. American Journal of Agricultural Economics 86:1238-1246.
  • Chema, K., Marks, L.A., Parcell, J. and Bredahl, M. 2006. Marketing biotech functional foods in the US. Canadian Journal of Agricultural Economics [Under Review].
  • Qiu, X., Eastridge, M.L., Griswold, K.E. and Firkins, J.K. 2004. Effects of substrate, passage rate, and pH in continuous culture on flows of conjugated linoleic acid and trans C18:1. J. Dairy Sci. 87:3473-3479.
  • Griswold, K.E., Apgar, G.A., Robinson, R.A., Jacobson, B.N., Johnson, D. and Woody, H.D. 2003. Effectiveness of short-term feeding strategies for altering conjugated linoleic acid (CLA) content of beef. J. Anim. Sci. 81:1862-1871.
  • Shay, N. and Banz, W.J. 2005. Regulation of gene transcription by botanicals. Annual Review of Nutrition, Volume 25:297-315.
  • Davis, J., Iqbal, M.J., Steinle, J., Oitker, J., Higginbotham, A., Peterson, R. and Banz, W.J. 2005. Soy protein influences the development of the metabolic syndrome in male obese ZDFxSHHF rats. Hormone and Metabolic Research 37:316-325.
  • Davis, J., Steinle, J., Higginbotham, A., Oitker, J., Peterson, R. and Banz, W.J. 2005. Soy protein influences insulin-sensitivity and cardiovascular risk in male lean SHHF rats. Hormone and Metabolic Research 37:309-315.
  • Sporleder, T.L. and Goldsmith, P.D. 2001. Alternative firm strategies for signaling quality in the food system. Canadian Journal of Agricultural Economics 49 (4) 2001: 591-604.
  • Wansink, B. 2004. Marketing nutrition: Soy, functional foods, biotechnology, and obesity. Champaign, IL: University of Illinois Press.
  • Wansink, B. 2004. Consumer reactions to food safety crises, advances in food and nutrition research [Forthcoming].
  • Ralston, L., Subramanian, S., Matsuno, M. and Yu, O. 2005. Partial reconstruction of flavonoid and isoflavonoid biosynthesis in yeast (Saccharomyces cerevisiae) using soybean type I and type II chalcone isomerases. Plant Physiology 137: 1375-1388.
  • Ricketts, M., Moore, D., Banz, W., Mezei, O. and Shay, N. 2003. The mechanism of isoflavone action includes activation of PPAR pathways. J. Nutr. Biochem. (Accepted).
  • Banz, W.J., Davis J., Peterson, R. and Iqbal, M.J. 2004. Gene expression and adiposity are modified by soy protein in male ZDF rats. Obesity Research 12:1907-1913.
  • Jones, K., Harty, J., Roeder, M., Winters, T. and Banz, W. 2004. In vitro effects of soy phytoestrogens on rat L6 skeletal muscle cells. Journal of Medicinal Food. Vol. 8.
  • Higginbotham, D.A., Iqbal, M.J., Majewski, H., Davis, J. and Banz, W.J. 2005. A comparison of egg, mik and soy dietary protein in development of obesity in diet induced obese (DIO) and diet resistant (DR) rats. The FASEB Journal.
  • Banz, W., Moustaid-Moussa, N., Kim, Y.-C., Cho, K., Shay, N., Higginbotham, A., Davis, J. and Peterson, R. 2004. Soy protein regulates adiposity, insulin-sensitivity and lipogenic capacity in male ZDF rats. The FASEB Journal.
  • Rimal, A. and Moon, W. 2005. Agricultural biotechnology and organic food consumption. British Food Journal. Vol 107. No. 2, 2005 (84-96).
  • Moon, W. and Balasubramanian, S.K. 2004. Is there a market for GM foods in Europe? Contingent valuation of GM and non-GM breakfast cereals in the UK. AgBioForum, 6 (3), 2004: 128-133.
  • Moon, W. and Balasubramanian, S. 2004. Public attitudes toward agrobiotechnology: The mediating role of risk perceptions on the impact of trust, awareness and outrage. Review of Agricultural Economics, vol 26 No. 2, 2004: 186-208.
  • Turan, N.A. and Goldsmith, P.D. 2005. Legal systems, institutional environment, and food safety. Agricultural Economics [Under Review].
  • Turan, N. and Goldsmith, P.D. 2005. Governments and firms: Incentives to supply safe food. Food Policy [Under Review].
  • Goldsmith, P.D., Turan, N. and Gow, H.R. 2003. Food safety in the meat industry: A regulatory quagmire. International Food and Agribusiness Management Review. 6(1) 2003.
  • Subramainan, S., Graham, M.L., Yu, O. and Graham, T. 2005. Silencing of soybean isoflavone synthase through an RNAi approach leads to silencing in non-transformed tissue and to enhanced susceptibility to Phytophthora sojae. Plant Physiology 137: 1345-1353.
  • Yu, O. and McGonigle, B. 2005. Metabolic engineering of isoflavone biosynthesis. Advances in Agronomy 86: 147-189.
  • Bennett, J.O., Yu, O., Heartherly, L.G. and Krishnan, H.B. 2004. Accumulation of genistein and daidzein, soybean isoflavones implicated in promoting human health, is significantly elevated by irrigation. Journal of Agricultural and Food Chemistry 52: 7574-7579.
  • Subramanian, S., Xu, L., Lu, G., Odell, J. and Yu, O. 2004. The promoters of the isoflavone synthase genes respond differentially to nodulation and defense signals in transgenic soybean roots. Plant Molecular Biology 54:226-239.
  • Banz, W.J. 2005. The effect of diet and gender on the development and progression of diabetes and obesity in various preclinical models: Implications for pharmaceutical and nutraceutical research. 2nd Charles River Symposium for Type 2 Diabetes and its Complications.
  • Banz, W.J. 2005. The influence of soy consumption on the development and progression of Type 2 diabetes mellitus. Obesity Management: Role of Soy Foods, University of Illinois Research Forum.
  • Banz, W.J., Adler, S., Shay, N.F., Ross-Viola, J., Winters, T., Hou, Y. and Meyers, C.Y. 2005. Phytoestrogens and a non-steroidal selective estrogen receptor modulator are also ligands for PPAR-v. The FASEB Journal.
  • Ralston, L. and Yu, O. 2003. [Patent] In vivo reconstruction of the flavonoid and isoflavonoid pathway. Technology Disclosure from the Donald Danforth Plant Science Center.
  • Kalaitzandonakes, N. and Kaufman, J. 2006. GM crops impact starch industry. Grain World, February 2006.
  • Chema, S.K. 2004. Marketing of biotech functional foods in the U.S. MSc. Thesis, Department of Agricultural Economics, Univeristy of Missouri, Columbia, Missouri.
  • Chema, K., Marks, L.A., Parcell, J. and Bredahl, M. 2004. Marketing biotech functional foods in the U.S. Selected paper presented at the American Agricultural Economics Association Annual Meetings, July 31st to August 4th, Colorado.
  • Kalaitzandonakes, N., Marks, L.A. and Vickner, S.S. 2005. Market evidence of consumer response to mandated genetically modified food labels. Invited paper presented at Labeling Genetically Modified Food: an Interdisciplinary Conference at the University of Missouri-Columbia, Columbia Missouri, November 4-5, 2005.
  • Xiaohong, L., Jamai, A., Meksem, K. and Mitchum, M.G. 2005. Elucidating the molecular mechanism of soybean resistance to soybean cyst nematode. MU Life Sciences Week 2005, Poster Presentation.
  • AbuGhazaleh, A., Apgar, G. and Jacobson, B. 2005. The effect of docosahexaenoic acid on the production of vaccenic acid and conjugated linoleic acid from unsaturated C18 fatty acids in rumen cultures. J. Anim. Sci. 83(Suppl. 1):180.
  • AbuGhazaleh, A., Apgar, G. and Jacobson, B. 2005. The effect of low pH on the production of trans monoenes and conjugated linoleic acid in rumen cultures containing docosahexaenoic acid and unsaturated 18 carbons fatty acids. J. Anim. Sci. 83(Suppl. 1):180.
  • AbuGhazaleh A., Apgar, G., Buckles, R. and Kalscheur, K. 2005. Production of trans monoenes and conjugated linoleic acid in continuous cultures fed diets containing fish oil and sunflower oil with decreasing levels of forage. J. Anim. Sci. 83:(Suppl 1):181.
  • Davis, J., Higginbotham, A., Iqbal, M.J., Moustaid-Moussa, N., O'Connor, T., Shay, N., Adler, S., Peterson, R. and Banz, W.J. 2005. Soy protein and isoflavones influences adiposity and development of metabolic syndrome in the obese male ZDF rat. J. Nutrition [Submitted].
  • Cho, K., Banz, W.J., Davis, J. and Kim, Y.C. 2005. Soy isoflavones increase PPAR and GLUT4 gene expression in 3T3-L1 adipocytes and ameliorate the metabolic syndrome in Zucker diabetic fatty rat. J. Nutr. [Under Revision].
  • Adler, S., Banz, W.J., Shay, N.F., Ross-Viola, J., Winters, T., Hou, Y. and Meyers, C.Y. 2005. Phytoestrogens and a non-steroidal selective estrogen receptor modulator are also ligands for PPAR-v. ENDO 2005, The Endocrine Society's 87th Annual Meeting, June 4-7 in San Diego, California.
  • Banz, W.J. 2005. The influence of soy consumption on the development and progression of Type 2 diabetes mellitus. Obesity Management: Role of Soy Foods, University of Illinois, Invited Symposium Paper.
  • Davis, J., Higginbotham, A., Peterson, R. and Banz, W. 2004. Soy protein influence the development of hypertension and insulin-resistance in male ZDFxSHHF rats. The FASEB Journal.
  • Wansink, B. and Westgren, R. 2004. When does nutritional knowledge relate to the acceptance of a functional food? University of Illinois Working Paper.
  • Balasubramanian, S.K., Moon, W. and Putis, W. 2004. Choice-based conjoint analysis of public perceptions of genetically modified foods. Amsterdam, Netherlands, July 2004.
  • Moon, W., Rimal, A. and Balasubramanian, S.K. 2004. Contingent valuation of GM and non-GM foods in the UK: Application of cheap talk script method. Presented at Annual American Agricultural Economics Association Meeting. Denver, CO. Aug 2004.
  • Rimal, A., Moon, W. and Balasubramanian, S.K. 2004. An evaluation of consumer acceptance of genetically modified foods: Willingness-to-pay (WTP) vs. willingness-to-accept (WTA). Presented at Southern Agricultural Economics Association Annual Meeting. Tulsa, OK. Feb. 2004.
  • Goldsmith, P.D., Turan, N. and Gow, H. 2004. (Micro) Economics of food safety. Presented at the Department of Agricultural and Consumer Economics University of Illinois Seminar Sseries, April, 2004.
  • Goldsmith, P.D., Turan, N. and Gow, H. 2004. Firms incentives and the supply of food safety: A formal model of government enforcement. Presented at the Annual Meeting of the American Agricultural Economics Association, Denver, Colorado, August, 2004.
  • Matsuno, M., Ralstonm L., Subramanian, S., Walker, L. and Yu, O. 2004. In vivo reconstruction of flavonoid and isoflavonoid biosynthesis in yeast using type I and type II chalcone isomerases from soybean. Invited for oral presentation at the 2004 ASPB Annual Meeting minisymposium-Secondary Metabolism.
  • Subramanian, S., Menne, C., Odell, J.T., Stacey, G. and Yu, O. 2004. Isoflavones are essential for the establishment of symbiosis between soybean and Bradyrhizobium japonicum. Invited for oral presentation at the 2004 ASPB Annual Meeting Minisymposium-Symbiosis.
  • Subramanian, S., Matsuno, M., Menne, C., Ralston, L. and Yu, O. 2004. From transcriptional regulation to metabolic channeling: Understanding the flavonoid and isoflavonoid pathway for metabolic engineering. Invited for oral presentation at the Soy 2004 Meeting at Columbia, MO.
  • Matsuno, M., Ralston, L., Subramanian, S., Walker, L. and Yu, O. 2004. Metabolic engineering of phytoestrogenic compounds - isoflavones. Invited for oral presentation at the International Symposium on Profiling and the Use of Plant Metabolites and Medicinal Phytocompounds at Taipei, Taiwan.
  • Yu, O. 2004. Metabolic engineering of soybean phytoestrogens. Presented at the International Symposium on Research into Plant Metabolites and Medicinal Phytocompounds. Taipei, Taiwan. Dec 2004.
  • Yu, O. 2004. Metabolic regulations of isoflavonoid biosynthsis. Dept. of Biochemistry, Fudan University, Shanghai, China. Dec. 2004.
  • Yu, O. 2004. In vitro reconstruction of flavonoid and isoflavonoid pathway in yeast. Presented at the ASPB Annual Meeting. Orlando, FL. July 2004.
  • Yu, O. 2004. Isoflavones are essential during soybean bradyrhizobium interactions. Presented by Senthil Subramanian (postdoc) at ASPB Annual Meeting. Orlando, FL, July 2004.
  • Yu, O. 2005. RNAi silencing of soybean defense genes leads to altered responses to elicitors and infection in both transformed and distal tissues. An invited seminar given by Dr. Terry Graham at the joint meeting of MPMI@Ohio (Molecular Plant Microbes at Ohio) and the PMBB (Plant Molecular Biology and Biotechnology) Symposium, April 15, 2005.
  • Yu, O. 2004. The biological functions of isoflavones during soybean Bradyrhizobium interactions. Inst. Of Botany, Academia Sinica. Dec. 2004.
  • Yu, O. 2004. From transcriptional regulation to metabolic channeling: Metabolic engineering of flavonoid and isoflavonoid biosynthesis. Presented at the Soy 2004 Symposium. Columbia, MO. Aug 2004.


Progress 01/01/05 to 12/31/05

Outputs
The broad goal of the Illinois Missouri Biotechnology Alliance is to strengthen the agriculture and food sectors in the American Midwest, especially the improvement of food safety and quality. The Alliance funds investigator-driven research under two subprograms, one aimed at enhancing profitability and one focused on economics and consumer acceptance. Nine projects were funded by the Illinois-Missouri Biotechnology Alliance in 2005. Detailed information can be found at the program website http://www.imba.missouri.edu/. (1) Genetic Enhancement Of The Antioxidant Content Of Soybean Oil For Improved Food Processing, Lubricant And Nutriceutical Properties. (2) Identification Of Key Defense Genes For Resistance To Phytopthora Stem And Root Rot Through Gene Silencing. (3) Developing Targeted Resistance To Soybean Cyst Nematode In Soybean. (4) Breeding For Enhanced Molecular Farming In Maize Seeds. (5) Development Of Corn/Soy Plastic Composites. (6) Compliance Costs Of Regulation In The Development Of Differentiated Product Channels. (7) Agricultural Biotechnology, CAFTA, And The Development Of Differentiated Product Channels. (8) Novel Crop Biotechnologies And The United States Ethanol Industry. (9) Evaluating The Outcomes Of IMBA Research. Four projects have been funded so far by the Illinois-Missouri Biotechnology Alliance in 2006. (1) Development Of Corn/Soy Plastic Composites: Phase II. (2) Adaptation Of A Gene Switch Technology For Use In Soybean Seed. (3) Maximizing The Value Of Corn Biotechnologies In Ethanol Production. (4) Analytical Tools For Production Of Non-Food Protein Corn.

Impacts
The Illinois-Missouri Biotechnology Alliance (IMBA) is a joint program of the University of Illinois and the University of Missouri and is funded by a Congressional Special Grant administered by the United States Department of Agriculture (USDA). The purpose of IMBA is to fund biotechnology research that is an integral part of a Research and Development (R&D) program directed at expanding the volume of profitable businesses in the United States (U.S.) food and agricultural sector. Initially, the IMBA program was limited in scope to corn and soybeans. However, the scope of IMBA interest now encompasses all concepts of these industries including production, processing, marketing, utilization, inputs and support services, as well as economic, social, environmental, and natural resource concerns. The geographical focus of IMBA is Illinois and Missouri along with other Midwestern states having similar crops, soils, climate, and socio-economic conditions.

Publications

  • Shay, N. and Banz, W.J. 2005. Regulation of gene transcription by botanicals. Annual Review of Nutrition Volume 25:297-315.
  • Davis, J., Iqbal, M.J., Steinle, J., Oitker, J., Higginbotham, A., Peterson, R. and Banz, W.J. 2005. Soy protein influences the development of the metabolic syndrome in male obese ZDF x SHHF rats. Hormone and Metabolic Research 37:316-325.
  • Davis, J., Steinle, J., Higginbotham, A., Oitker, J., Peterson, R. and Banz, W.J. 2005. Soy protein influences insulin-sensitivity and cardiovascular risk in male lean SHHF rats. Hormone and Metabolic Research 37:309-315.
  • Ralston, L. Subramanian, S., Matsuno, M. and Yu, O. 2005 . Partial reconstruction of flavonoid and isoflavonoid biosynthesis in yeast (Saccharomyces cerevisiae) using soybean type I and type II chalcone isomerases. Plant Physiology 137: 1375-1388.
  • Subramainan, S., Graham, M.L., Yu, O. and Graham, T. 2005. Silencing of soybean isoflavone synthase through an RNAi approach leads to silencing in non-transformed tissue and to enhanced susceptibility to Phytophthora sojae. Plant Physiology 137: 1345-1353.
  • Yu, O. and McGonigle, B. 2005. Metabolic engineering of isoflavone biosynthesis. Advances in Agronomy 86: 147-189.
  • Ralston, L. and Yu, O. 2003. In vivo reconstruction of the flavonoid and isoflavonoid pathway. Technology Disclosure from the Donald Danforth Plant Science Center.
  • English, J.T. and Schmidt, F.J. 2004. Phage Display Selection of Antifungal Peptides (US Patent Application serial no. 09/829,549).
  • Davis, J., Higginbotham, A., Iqbal, M.J., Moustaid -Moussa, N., O'Connor, T., Shay, N., Adler, S., Peterson, R. and Banz, W.J. 2005. Soy protein and isoflavones influences adiposity and development of metabolic syndrome in the obese male ZDF rat. J. Nutrition (Submitted).
  • Cho, K., Banz, W.J., Davis, J. and Kim, Y.C. 2005. Soy isoflavones increase PPAR and GLUT4 gene expression in 3T3-L1 adipocytes and ameliorate the metabolic syndrome in Zucker Diabetic Fatty rat. J. Nutrition (Under Revision).


Progress 01/01/04 to 12/31/04

Outputs
Eight subprojects have been awarded competitively with funding from this grant. The subjects are as follows: 1. Genetic enhancement of the antioxidant content of soybean oil (to USDA-ARS). The major focus of this research will be the development of soybean lines with seed oils that have increased oxidative stability. Oxidative stability is central to the use of soybean oil for food processing. About 96% of the 18.3 billion pounds of soybean oil consumed annually in the United States is used for food applications. This represents an annual market of approximately $3.5 billion dollars. 2. Identification of plant disease defense genes (to Ohio State University and the Donald Danforth Plant Science Center). This project will address the profitability of soybeans at the production level through basic research that will lead to identification of genetically defined processes and traits that can be modified for enhanced disease resistance. 3. Targeting resistance to soybean cyst nematode (University of Missouri and Southern Illinois University). This collaborative, innovative, discovery research will seek to define the underlying mechanism of soybean resistance to SCN, the product of which has both economic and environmental potential. 4. Breeding for enhanced molecular farming in maize (University of Illinois). This project will develop methods and technologies for enhancing corn profitability. New germplasm will be created that combines existing genetic strategies for increasing protein yields and transgene containment in a single maize genotype, which promises to remedy the major limitations of producing recombinant proteins in maize seeds. 5. Development of corn/soy plastic composites (Iowa State University). With the help of this research, soy/corn plastics can be made at a significantly lower cost than most petroleum-based resins using well established technology. Anticipated is that new, affordable polymer composites with industrially viable properties will be developed that should find wide utility as structural materials. 6. Compliance costs for regulating biotech crops (University of California-Davis and the University of Missouri). The objective of this research is to provide the first estimates of the private compliance costs of the regulatory approval system for agrifood biotechnologies. 7. Novel crop technologies and the ethanol industry (University of Missouri). The project will evaluate and optimize the impacts of three early corn biotechnologies on the ethanol industry, prior to physical adoption. 8. Evaluating the outcomes of IMBA-sponsored research (University of Illinois). This project will measure the extent to which research funded by the Illinois Missouri Biotechnology Alliance led to and is leading to new and improved technology employed in the industries involved in producing, processing, distributing, marketing, and utilizing corn and soybeans.

Impacts
The Illinois-Missouri Biotechnology Alliance (IMBA) is a joint program of the University of Illinois and the University of Missouri and is funded by a Congressional Special Grant administered by the United States Department of Agriculture (USDA). The purpose of IMBA is to fund biotechnology research that is an integral part of a Research and Development (R&D) program directed at expanding the volume of profitable businesses in the United States (U.S.) food and agricultural sector. Initially, the IMBA program was limited in scope to corn and soybeans. However, the scope of IMBA interest now encompasses all concepts of these industries including production, processing, marketing, utilization, inputs and support services, as well as economic, social, environmental, and natural resource concerns. The geographical focus of IMBA is Illinois and Missouri along with other Midwestern states having similar crops, soils, climate, and socio-economic conditions.

Publications

  • No publications reported this period


Progress 01/01/03 to 12/31/03

Outputs
The broad goal of the Illinois Missouri Biotechnology Alliance is to strengthen the agriculture and food sectors in the American Midwest, especially the improvement of food safety and quality. The Alliance funds investigator-driven research under two subprograms, one aimed at enhancing profitability and one focused on economics and consumer acceptance. The Enhanced Profitability Program specifically seeks to identify new and improved uses for crops and materials that can be manufactured from them. The Socioeconomic Research Program seeks to anticipate and understand the economic and social impacts of agricultural biotechnology and capture as many of the benefits as possible for the American agricultural sector. Specific objectives that fall within the above categories are identified annually by an Executive Board, and grants are awarded to individual investigators following peer review of proposals. Research publications and outcomes are reported individually by principal investigators. For additional information on the Illinois-Missouri Biotechnology Alliance please consult our website at www.imba.missouri.edu.

Impacts
The Illinois-Missouri Biotechnology Alliance (IMBA) is a joint program of the University of Illinois and the University of Missouri and is funded by a Congressional Special Grant administered by the United States Department of Agriculture (USDA). The purpose of IMBA is to fund biotechnology research that is an integral part of a Research and Development (R&D) program directed at expanding the volume of profitable businesses in the United States (U.S.) food and agricultural sector. Initially, the IMBA program was limited in scope to corn and soybeans. However, the scope of IMBA interest now encompasses all concepts of these industries including production, processing, marketing, utilization, inputs and support services, as well as economic, social, environmental, and natural resource concerns. The geographical focus of IMBA is Illinois and Missouri along with other Midwestern states having similar crops, soils, climate, and socio-economic conditions.

Publications

  • No publications reported this period