Progress 10/01/02 to 09/30/12
Outputs
OUTPUTS: Resources from this project enable the management of several different Biochemistry programs: Howard Hughes Medical Institute, Biochemistry Colloquium and Contemporary Biochemistry Seminar Series, and the Wisconsin Distinguished Graduate Fellowship. PARTICIPANTS: Anath Shalev (UW-Madison), Michael Brownlee (Albert Einstein College of Medicine), Aki Ikeda (UW-Madison), Navdeep S. Chandel (Northwestern-Chicago), David Bernlohr (Univ of Minnesota), Marc Montminy (Salk Institute), Jonathan Weissman (UC-San Francisco), Debbie Muoio (Duke Univ), Andrew Dillin (Salk Institute), Dorothy Sears (UC-San Diego), Feroz Papa (UC-San Francisco), Marc Van Gilst (Fred Hutchinson Cancer Research Cntr), Pere Pulgserver (Harvard), Juleen Zierath (Karolinska Institutet), Juleen Zierath (Karolinska Institutet-Sweden), David Chan (California Institute of Technology), Ben Cravatt (Scripps Research Institute), Abbas Ourmazd (UW-Milwaukee), Grover Waldrop (Louisiana State Univ), Ming Lei (Univ of Michigan), Domenico Accili (Columbia Univ), Tanja Kortemme (UC-San Francisco), Josh Kaplan (Harvard), Dustin Maly (Univ of Washington), Robert Jernigan (Iowa State Univ), Andrew Hinck (Univ of Texas-San Antonio), James Chen (Stanford), David Zarkower (Univ of Minnesota), David Auble (Univ of Virginia), Chris Walsh (Harvard), Tony Pawson (Samuel Lunenfeld Research Institute), Craig Pikaard (Indiana Univ-Bloomington), Jim Wells (UC-San Francisco). Wisconsin Distinguished Graduate Fellowships supported: Theodore Gries, Marielle Gruenig, Stephen Tumasz. TARGET AUDIENCES: The target audiences would be the biochemical, biophysical, and chemical scientific research communities with the intent of increasing and/or disseminating scientific knowledge. PROJECT MODIFICATIONS: Not relevant to this project.
Impacts
This project provides programs with support so that they may continue developing, generating research results and attracting talented scholars which will enhance the department, the UW, and the science community as a whole.
Publications
- No publications reported this period
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Progress 01/01/09 to 12/31/09
Outputs
OUTPUTS: Resources from this project enable the management of several different Biochemistry programs: Howard Hughes Medical Institute, Biochemistry Colloquium and Contemporary Biochemistry Seminar Series, Wisconsin Distinguished Graduate Fellowship, and the Cluster Enhancement Grant for the Chemical Biology Cluster. PARTICIPANTS: Donald Engelman (Yale), Josep Rizo (UT Southwestern Medical Center at Dallas), John Bushweller (University of Virginia), Brian Crane (Cornell), Brian Kobilka (Stanford California), Kerwyn Casey Huang (Stanford), William Dowhan (University of Texas-Houston Medical School), James Bowie (UCLA), Anne Kenworthy (Vanderbilt School of Medicine), Janet Wood (University of Guelph), Gunnar von Heijne (Stolkholm University), James Weisshaar (UW-Madison), Amy Keating (MIT), Myron Goodman (University of Southern California), Chaitan Khosla (Stanford), Deborah Thurmond (University of Indiana), William DeGrado (University of Pennslyvania), David Baker (University of Washington), Oliver Fiehn (University of California, Davis), Anna Mapp (University of Michigan), Randall Peterson (Harvard), Jason Gestwicki (University of Michigan), Hashim Al-Hashimi (University of Michigan), Todd Michael (Rutgers), Susan Gilbert (Rensselaer Polytechnic Institute, NY), Vahe Bandarian (University of Arizona) Wisconsin Distinguished Graduate Fellowships supported (in part) Marielle Gruenig, YeJin Eun, Theodore Gries. TARGET AUDIENCES: The target audiences would be the biochemical, biophysical, and chemical scientific research communities with the intent of increasing and/or disseminating scientific knowledge. PROJECT MODIFICATIONS: Not relevant to this project.
Impacts
This project provides programs with support so that they may continue developing, generating research results and attracting talented scholars which will enhance the department, the UW, and the science community as a whole.
Publications
- No publications reported this period
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Progress 01/01/08 to 12/31/08
Outputs
OUTPUTS: Resources from this project enable the management of several different Biochemistry programs: Howard Hughes Medical Institute, Biochemistry Colloquium and Contemporary Biochemistry Seminar Series, Wisconsin Distinguished Graduate Fellowship, and the Cluster Enhancement Grant for the Chemical Biology Cluster. PARTICIPANTS: Chris Somerville (UC Berkley), Mike Seibert (Nat Renewable Energy Lab), Robert Zubrin (Pioneer Astronautics), James Liao (UCLA), Clint Chapple (Purdue Univ), Jason Hill (Univ of Minnesota), Alexander Steinbuchel (Westfalische Wilhelms Univ. of Munster, Germany), Debra Mohnen (Univ. of Georgia), Alisha Jarnagin (Innovations Genencor, A Danisco Div), Thomas Binder (Archer Daniels Midland Rsch), Jay Keasling (UC Berkley), Roger Brent (Molecular Sciences Inst), Tim Elgren (Hamilton College NY), John Ralph (UW Madison), Tim Donohue (UW Madison), Robert Powers (Univ of NE Lincoln), Sarah Oconnor (MIT), Rohit Kulkarni (Harvard Medical Center), Alvin Powers (Vanderbilt Univ), Milan Mrksich (Univ. of Chicago), Christian Raetz (University of CO Boulder), Rebecca Heald (UC Berkeley), Oliver Hobert (Columbia Univ), Tom Rapoport (Harvard Medical School), Cathy Drennan (MIT), Howard Berg (Harvard Univ), Peter Schultz (Scripps Resch Inst), Frances Arnold (Caltech),Karen Oegemea (UC San Diego) Wisconsin Distinguished Graduate Fellowships supported (in part)Ryan Marcheschi, Marielle Gruening, Ted Gries, Robert Nerenz, Rachel Britt. TARGET AUDIENCES: The target audiences would be the biochemical, biophysical, and chemical scientific research communities with the intent of increasing and/or disseminating scientific knowledge. PROJECT MODIFICATIONS: Not relevant to this project.
Impacts
This project provides programs with support so that they may continue developing, generating research results and attracting talented scholars which will enhance the department, the UW, and the science community as a whole.
Publications
- No publications reported this period
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Progress 01/01/07 to 12/31/07
Outputs
OUTPUTS: Resources from this project enable the management of several different Biochemistry programs: Howard Hughes Medical Institute, Biochemistry Colloquium and Contemporary Biochemistry Seminar Series, Wisconsin Distinguished Graduate Fellowship, and the Cluster Enhancement Grant for the Chemical Biology Cluster. These funds cover the scholar expenses and administrative costs, manage donations, and support stipends.
PARTICIPANTS: Speakers supported by the seminar series include Toshio Tsukiyama (Fred Hutchinson Cancer Research Center), Carol Greider (Johns Hopkins University), Jerry Workman (Stowers Institute for Medical Research), Susan Wente (Vanderbilt University), Robert Landick (UW Madison), Tom Misteli (National Cancer Institute, NIH), Paul Kaufman (University of Massachusetts), Bruce Stillman (Cold Spring Laboratory), Jonathan Widom (Northwestern), Matthew Michael (Harvard), and Marc Gartenberg (Robert Wood Johnson Medical School). Wisconsin Distinguished Graduate Fellowships supported (in part) Alison Albee (Wiese), Dennis Harris (Cox lab), and Thomas Rutkoski (Raines lab).
TARGET AUDIENCES: The target audiences would be the biochemical, biophysical, and chemical scientific research communities with the intent of increasing and/or disseminating scientific knowledge.
Impacts
This project provides programs with support so that they may continue developing, generating research results and attracting talented scholars which will enhance the department, the UW, and the science community as a whole.
Publications
- No publications reported this period
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Progress 01/01/06 to 12/31/06
Outputs
Resources from this project enable the management of several different Biochemistry programs: Howard Hughes Medical Institute, Biochemistry Colloquium and Contemporary Biochemistry Seminar Series, Wisconsin Distinguished Graduate Fellowship and the Cluster Enhancement Grant for the Chemical Biology Cluster. These funds cover scholar expenses and administrative costs, manage donations, and support stipends.
Impacts
This project provides programs with support so that they may continue developing, generating research results and attracting talented scholars which will profit the department, the UW, and the science community as a whole.
Publications
- C19-steroids as androgen receptor modulators: design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists. Bioorg Med Chem. 2006 Sep 1;14(17):5933-47. Epub 2006 Jun 8.
- Redox reactions of dehydroepiandrosterone and its metabolites in differentiating 3T3-L1 adipocytes: A liquid chromatographic-mass spectrometric study. Arch Biochem Biophys. 2006 Dec 1;456(1):1-7. Epub 2006 Oct 10.
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Progress 01/01/05 to 12/31/05
Outputs
Resources from this project enable the management of several different Biochemistry programs: Howard Hughes Medical Institute, Biochemistry Colloquium and Contemporary Biochemistry Seminar Series, Wisconsin Distinguished Graduate Fellowship and the Cluster Enhancement Grant for the Chemical Biology Cluster. These funds cover scholar expenses and administrative costs, manage donations, and support stipends.
Impacts
This project provides programs with support so that they may continue developing, generating research results and attracting talented scholars which will profit the department, the UW, and the science community as a whole.
Publications
- A postulated role for 16 alpha-hydroxydehydroepiandrosterone in the prevention of respiratory distress syndrome. Med Hypotheses. 2006;66(1):107-9. Epub 2005 Sep 15. PMID: 16168569 [PubMed - in process]
- C(19)-5-ene steroids in nature. Vitam Horm. 2005;71:263-99. Review. PMID: 16112271 [PubMed - indexed for MEDLINE]
- Development and validation of a high performance liquid chromatography assay for 17alpha-methyltestosterone in fish feed. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):107-15. PMID: 16046199 [PubMed - indexed for MEDLINE]
- [Failures of endoscopic treatment of vesico-ureteric reflux in children using Macroplastique] Prog Urol. 2005 Apr;15(2):291-5; discussion 295. French. PMID: 15999610 [PubMed - indexed for MEDLINE]
- Identification of steroid derivatives that function as potent antiandrogens. Int J Cancer. 2005 Dec 10;117(5):866-72. PMID: 15981214 [PubMed - indexed for MEDLINE]
- [Is procalcitonin able to help in pediatric appendicitis diagnosis?] Ann Chir. 2005 Mar;130(3):169-74. Epub 2005 Jan 7. French. PMID: 15784220 [PubMed - indexed for MEDLINE]
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Progress 01/01/04 to 12/31/04
Outputs
Resources from this project enable the management of several different Biochemistry programs: Howard Hughes Medical Institute, Biochemistry Colloquium and Contemporary Biochemistry Seminar Series, Wisconsin Distinguished Graduate Fellowship and the Cluster Enhancement Grant for the Chemical Biology Cluster. These funds cover scholar expenses and administrative costs, manage donations, and support stipends. Progress made in the research covered in these projects includes the following: 1) metabolites were quantified and identified by LC/MS; 2)a validated method for analysis of MT has been developed and submitted to Center for Veterinary Medicine; and 3)the main vitamin E metabolite CEHC has been synthesized to enable its direct assessment as an antiandrogen.
Impacts
This project provides programs with support so that they may continue developing, generating research results and attracting talented scholars which will profit the department, the UW, and the science community as a whole.
Publications
- Lardy, Henry A.; Marwah, Ashok; Marwah, Padma. U.S. Pat. Appl. Publ. (2004), 31 pp. Synthesis of antiandrogens with marginal agonist activity and methods of use for the treatment of androgen receptor-mediated conditions.
- Marwah, P; Marwah, A; Lardy, H. Green Chemistry (2004), 6, 570. An economical and green approach for the oxidation of olefins to enones.
- Lardy, H; Marwah, A; Marwah, P. (Hollis-Eden Pharmaceuticals, Inc., USA). PCT Int. Appl. (2004), 61 pp. Synthesis of antiandrogens with marginal agonist activity and methods of use for the treatment of androgen receptor-mediated conditions.
- Chang, C.; Chen, Y-T; Yeh, S; Xu, Q; Wang, R; Guillou, F; Lardy, H; Yeh, S. PNAS (2004), 101, 6876. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells.
- Suzuki, M; Wright, L; Marwah, P; Lardy, H; Svendsen, C. PNAS (2004), 101(9), 3202. Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex.
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Progress 01/01/03 to 12/31/03
Outputs
Resources from this project enable the management of several different Biochemistry programs: Howard Hughes Medical Institute, Biochemistry Colloquium and Contemporary Biochemistry Seminar Series, Wisconsin Distinguished Graduate Fellowship and the Cluster Enhancement Grant for the Chemical Biology Cluster. These funds cover scholar expenses and administrative costs, manage donations, and support stipends.
Impacts
This project provides each program with needed support so that it may continue offering excellent research results and attracting talented scholars which will profit the Biochemistry Department, the University of Wisconsin and the science community as a whole.
Publications
- No publications reported this period
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