Progress 05/01/02 to 04/30/04
Outputs
The most significant results during this period include: FLOREFENICOL/SHEEP (ADR #325): The final report "Pharmacokinetics of Nuflor (R) in Sheep" was submitted October 2003 to FDA/CVM for review. The human food safety was completed and the tissues are currently undergoing analyses in our laboratory. PROGESTERONE CIDRS/SHEEP (ADR #258): The target animal safety portion was completed and the final report is in preparation. FENBENDAZOLE/GAME BIRDS (ADR#280): Method validation has been completed and the final report is in preparation. Residues of Fenbendazole in Game Birds was presented as an abstract at the 2003 SOT meeting. ROMET-30 IN FISH (ADR#313): Western region laboratory has completed the sample analyses. The data are currently being evaluated. CEFTIOFUR/LLAMAS AND ALPACAS (ADR #275): Publication of "Pharmacokinetics of Ceftiofur in Llamas and Alpacas" has been submitted to the Journal of Veterinary Pharmacology and Toxicology (JVPT). CEFTIOFUR/RED DEER (ADR
#251): Publication of "Pharmacokinetics of Ceftiofur in Red Deer" has been submitted to JVPT. LINCOMYCIN/BEES (ADR #311): Target animal safety report has been accepted by FDA/CVM. TYLOSIN/BEES (ADR #217): Target animal and human food safety portions have been completed and reviewed by FDA/CVM. SPECIES GROUPING: Comparative metabolism studies continue. Preliminary results to date were presented at the 2004 SOT meeting.
Impacts
Pharmacokinetics, human food safety, and target animal safety studies are required by FDA/CVM to obtain minor and specialty animal drug clearances in minor species for drug registration. Data must be obtained for each animal species for which drug use in intended. These minor use animal drug registrations will impact the farmers and ranchers of the Western Region with the potential beneficiaries of this research being consumers in the Western Region and the rest of the United States.
Publications
- Payne, M.A., Babish, J.G., Bulgin, M., Lane, M., Wetzlich, S. and Craigmill, A.L. 2002. Serum pharmacokinetics and tissue and milk residues of oxytetracycline in goats following a single intramuscular injection of a long-acting preparation and milk residues following a single subcutaneous injection. Journal of Veterinary Pharmacology and Therapeutics, 25(1)25-32.
- Drew, M.L., Waldrup, K., Kreeger, T., Craigmill, A.L. Wetzlich, S.E. and Mackintosh, C. 2004. Pharmacokinetics of ceftiofur in red deer (Cervus elaphus). Journal of Veterinary Pharmacology and Therapeutics, 27(7-11).
- Drew, M.L., Johnson, L., Pugh, D., Navarre, C.B., Taylor, I.T. and Craigmill, A.L. 2004. Pharmacokinetics of ceftiofur in llamas and alpacas. Journal of Veterinary Pharmacology and Therapeutics, 27(13-20).
- Lane, VM, Villrroel, A, Wetzlich, S, Clifford, A. Taylor, I, and Craigmill, AL. 2004. Intravenous and subcutaneous pharmacokinetics of florfenicol in sheep. Accepted for publication: Journal of Veterinary Pharmacology and Therapeutics.
- Cortright, K.A. and Craigmill, A.L. 2002. Comparative hepatic microsomal enzyme studies in commercially raised gamebirds. (Abstract) 43nd Annual Meeting of the Society of Toxicology, #1695.
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Progress 01/01/03 to 12/31/03
Outputs
FLORFENICOL/SHEEP (ADR #325): The final report "Pharmacokinetics of Nuflor (R) in Sheep" was submitted to FDA/CVM for review. Human food safety was completed and the tissues are currently undergoing analyses. PROGESTERONE CIDRS/SHEEP (ADR #258): The target animal safety portion was completed and the final report is in preparation. FENBENDAZOLE/GAME BIRDS (ADR#280): Method validation has been completed and the final report is in preparation. Residues of Fenbendazole in Game Birds was presented as an abstract at the 2003 SOT meeting. ROMET-30 IN FISH (ADR#313): Western region laboratory has completed the sample analyses. The data are currently being evaluated. CEFTIOFUR/LLAMAS AND ALPACAS (ADR #275): Publication of "Pharmacokinetics of Ceftiofur in Llamas and Alpacas" has been submitted to the Journal of Veterinary Pharmacology and Toxicology (JVPT). CEFTIOFUR/RED DEER (ADR #251): Publication of "Pharmacokinetics of Ceftiofur in Red Deer" has been submitted to JVPT.
LINCOMYCIN/BEES (ADR #311): Target animal safety report has been accepted by FDA/CVM. TYLOSIN/BEES (ADR #217): Target animal and human food safety portions have been completed and reviewed by FDA/CVM. SPECIES GROUPING: Comparative metabolism studies continue. Preliminary results were presented at the 2003 SOT meeting.
Impacts
Pharmacokinetics, human food safety, and target animal safety studies are required by FDA/CVM to obtain minor and specialty animal drug clearances in minor species for drug registration. Data must be obtained for each animal species for which drug use in intended. These minor use animal drug registrations will impact the farmers and ranchers of the Western Region with the potential beneficiaries of this research being consumers in the Western Region and the rest of the United States.
Publications
- No publications reported this period
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Progress 01/01/02 to 12/31/02
Outputs
During this reporting period the following project goals were completed. Florfenicol in sheep (ADR #325): Pharmacokinetic studies were completed. More than 400 serum samples were collected for analysis after IM and IV dosing. Estimated time to completion of samples analysis is 5 months. Human Food Safety protocols are in development and the study is scheduled for early next year. Progesterone CIDRs for sheep (ADR #258): A protocol for Target Animal Safety is being developed. Fenbendazole in game birds (ADR #280 - collaborative project with the southern region): The method validation is being completed. Romet-30 in fish (ADR #313): The western region laboratory continues the analysis of samples. Ceftiofur in llamas and alpacas (ADR#275): Publication Pharmacokinetics of Ceftiofur in Red Deer has been completed and submitted to the Journal of Veterinary Pharmacology and Toxicology. Work continues on the Species Grouping project. Comparative metabolism studies have begun.
The assay system is currently being optimized and converted to a 96 well plate assay.
Impacts
Pharmacokinetics, human food safety, and target animal safety studies are required by FDA/CVM to obtain minor and specialty animal drug clearances in minor species for drug registration. Data must be obtained for each animal species for which drug use is intended. These minor use animal drug registrations will impact the farmers and ranchers of the Western Region with the potential beneficiaries of this research being consumers in the Western Region and the rest of the United States.
Publications
- Payne, M.A., Babish, J.G., Bulgin, M., Lane, M., Wetzlich, S. And Craigmill, A.L. Serum pharmacokinetics and tissue and milk residues of oxytetracycline in goats following a single intramuscular injection of a long-acting preparation and milk residues following a single subcutaneous injection. Journal of Veterinary Pharmacology and Therapeutics, 25(1)25-32, 2002.
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