Recipient Organization
IOWA STATE UNIVERSITY
S. AND 16TH ELWOOD
AMES,IA 50011
Performing Department
VETERINARY MEDICINE
Non Technical Summary
Properly designed antimicrobial regimens serve to alleviate pain and suffering while conserving livestock resources. However, these regimens have the potential to alter the antimicrobial susceptibility profile of commensal and pathogenic bacteria inhabiting these animals. We anticipate this VADS system will assist in controlling the development of resistent pathogens and the occurrence of antimicrobial residues in animals producing food for human consumption.
Animal Health Component
100%
Research Effort Categories
Basic
(N/A)
Applied
100%
Developmental
(N/A)
Goals / Objectives
The judicious use of antimicrobials under the control of veterinarians is vital to the health of both humans and animals. The long-term goal is to support the veterinary profession in preserving the efficacy of antimicrobials for therapeutic use in animals and humans. The goal is to develop a web-based, peer-reviewed antimicrobial decision support system centered on therapeutic applications that will allow food animal veterinary practitioners to utilize all available information in the construction of antimicrobial regimens. To achieve this our specific aims are: 1) Perform extensive literature searches to identify pharmacokinetic, pharmacodynamic, clinical trial, antimicrobial pathogen susceptibility, regulatory, food safety, and approval process information pertinent to the VADS System. 2) Develop and apply standard operating procedures for evaluating the quality and reliability of information and data for use in developing the System contents. 3) Apply the
principles of pharmacology in constructing therapeutic regimens for use when approved antimicrobial products are not effective as labeled. 4) Design a relational database allowing a user to efficiently search the VADS System for label and extralabel regimens based on therapeutic applications, and to then review regulatory and food safety information applicable to these regimens. 5) Subject the System content to review prior to release and then constantly upgrade the content on the basis of new information and review by users. Our expectation at the completion of this project is to have an antimicrobial decision support system in place that is widely used by veterinarians in private, academic, and industry practices as well as by veterinary students. We anticipate this system will assist in controlling the development of resistant pathogens and the occurrence of antimicrobial residues in animals producing food for human consumption.
Project Methods
The core of the VADS System is a relational database that will be used to manage the decision support information. Related tables include dose regimen, animal categories, and disease descriptions. The relational database is tied to the web site using a commercial web application server. This approach allows for web-based data input by review teams and for retrieval of dose and other disease specific information that is controlled by users of the system.