VETERINARY ANTIMICROBIAL DECISION SUPPORT SYSTEM (VADS)

• Sponsoring Institution: Cooperating Schools of Veterinary Medicine
• Project Status: TERMINATED
• Funding Source: STATE
• Reporting Frequency: Annual
• Accession No.: 0190746
• Project No.: IOWV-430-23-48
• Project Start Date: Apr 30, 2001
• Project End Date: Apr 29, 2006

Project Director
Apley, M. D.

Recipient Organization
IOWA STATE UNIVERSITY
S. AND 16TH ELWOOD
AMES,IA 50011

Performing Department
VETERINARY MEDICINE

Non Technical Summary
Properly designed antimicrobial regimens serve to alleviate pain and suffering while conserving livestock resources. However, these regimens have the potential to alter the antimicrobial susceptibility profile of commensal and pathogenic bacteria inhabiting these animals. We anticipate this VADS system will assist in controlling the development of resistent pathogens and the occurrence of antimicrobial residues in animals producing food for human consumption.

Animal Health Component

100%

Research Effort Categories

Basic

(N/A)

Applied

100%

Developmental

(N/A)

Classification

Knowledge Area (KA)	Subject of Investigation (SOI)	Field of Science (FOS)	Percent
311	3910	1180	100%

Knowledge Area
311 - Animal Diseases;

Subject Of Investigation
3910 - Cross-commodity research--multiple animal species;

Field Of Science
1180 - Pharmacology;

Keywords

food safety

pharmacology

veterinary medicine

anti microbial agents

decision making

data bases

zoonoses

veterinarians

animal diseases

resistance management

antibiotic resistance

world wide web

systems development

therapeutics

pharmacokinetics

pharmacodynamics

process development

pesticide residues

information dissemination

livestock production

Goals / Objectives
The judicious use of antimicrobials under the control of veterinarians is vital to the health of both humans and animals. The long-term goal is to support the veterinary profession in preserving the efficacy of antimicrobials for therapeutic use in animals and humans. The goal is to develop a web-based, peer-reviewed antimicrobial decision support system centered on therapeutic applications that will allow food animal veterinary practitioners to utilize all available information in the construction of antimicrobial regimens. To achieve this our specific aims are: 1) Perform extensive literature searches to identify pharmacokinetic, pharmacodynamic, clinical trial, antimicrobial pathogen susceptibility, regulatory, food safety, and approval process information pertinent to the VADS System. 2) Develop and apply standard operating procedures for evaluating the quality and reliability of information and data for use in developing the System contents. 3) Apply the principles of pharmacology in constructing therapeutic regimens for use when approved antimicrobial products are not effective as labeled. 4) Design a relational database allowing a user to efficiently search the VADS System for label and extralabel regimens based on therapeutic applications, and to then review regulatory and food safety information applicable to these regimens. 5) Subject the System content to review prior to release and then constantly upgrade the content on the basis of new information and review by users. Our expectation at the completion of this project is to have an antimicrobial decision support system in place that is widely used by veterinarians in private, academic, and industry practices as well as by veterinary students. We anticipate this system will assist in controlling the development of resistant pathogens and the occurrence of antimicrobial residues in animals producing food for human consumption.

Project Methods
The core of the VADS System is a relational database that will be used to manage the decision support information. Related tables include dose regimen, animal categories, and disease descriptions. The relational database is tied to the web site using a commercial web application server. This approach allows for web-based data input by review teams and for retrieval of dose and other disease specific information that is controlled by users of the system.

Progress 01/01/02 to 12/31/02

Outputs
Pharmacokinetic references are prioritized and a superpositioning program has been written by Dr. Langston to automate superpositioning of reference data to simulate steady-state pharmacokinetics. Additional susceptibility data is being sought to strengthen the susceptibility portion of the project. The structure of the web-site is being adapted to our current data structure.

Impacts
The VADS System is expected to support veterinarians in prudent use of antimicrobials for therapeutic applications in food animals.

Publications

• No publications reported this period

Progress 01/01/01 to 12/31/01

Outputs
The literature search stage of the project is complete and the literature selection process is being completed for swine and bovine applications. Pharmacokietic modeling approaches are being standardized and an approach has been agreed upon with the Grants Management Committee of the FDA/CVM. A database of pharmacokinetic data is being finalized along with a bibliography of literature sources used to construct regimens on the system.

Impacts
The VADS System is expected to support veterinarians in prudent use of antimicrobials for therapeutic applications in food animals.

Publications

• No publications reported this period