Progress 01/15/96 to 01/14/05
Outputs
The UC Davis Center for Comparative Medicine (CCM) is a cooperative, interdisciplinary research center co-sponsored by the Schools of Medicine and Veterinary Medicine. The CCM research mission is to investigate host-agent interactions and develop intervention strategies for persistent infectious diseases common to humans and animals. Society faces immediate problems in regard to persistent infectious diseases, which are becoming more urgent as world population grows, people are living longer and infectious and zoonotic diseases are emerging at an increasing rate. It has been decided that, in the future, each individual project will be reported separately to CRIS, rather than have one 'blanket' or 'umbrella' project to cover this Center. CALV-MARKEY-96-15, therefore, is being terminated at this time.
Impacts
Persistent infections/diseases, including viral (e.g. acquired immune deficiency syndrome virus, cytomegalovirus, papilloma viruses, etc.), bacterial (e.g. Lyme disease, ehrlichiosis, tuberculosis, etc.), and parasitic (e.g. malaria, babesiosis, metazoan parasitism, etc.) are shared by both humans and animals or induced by closely related agents in humans and animals. Investigation of these diseases, which have enormous impact on society, will benefit both humans and animals.
Publications
- No publications reported this period
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Progress 01/01/01 to 12/31/01
Outputs
Current CCM-related research involves human, simian and feline immunodeficiency viruses; human, simian, bovine, feline and murine leukemia viruses; human and simian cytomegaloviruses; human and simian papillomaviruses; human and animal Lyme disease; human and animal ehrlichiosis; and murine gene targeting for animal model development. The scope of the research program will expand as CCM faculty recruitment progresses. CCM faculty members possess a broad range of complementary and interdisciplinary expertise that should lead to novel approaches to prevention and therapy of persistent infectious diseases that have proven otherwise refractory to clinical intervention by conventional means. CCM faculty members also provide expertise beyond infectious disease models, including laboratory animal sciences and model development.
Impacts
The primary concept of Comparative Medicine, captured in its name, implies that human and animal diseases share common features that can be exploited to develop strategies toward prevention and therapy. The UC Davis Schools of Medicine and Veterinary Medicine have a rich background of collaborative research into genetic diseases, cancer, organ transplantation, and infectious diseases, and the CCM is the embodiment of this "One Medicine" concept. Another unifying theme of the CCM, persistent infectious diseases common to humans and animals, represents one of the most important problems of our times. CCM research programs thus encompass several principal areas: Host-agent interactions during persistent infections, Mechanisms of oncogenesis by infectious agents, Intervention strategies for prevention and amelioration of persistent infections,
Publications
- A complete list of publications for 1999 may be obtained from the Center for Comparative Medicine, School of Veterinary Medicine, University of California Davis, Davis California.
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Progress 01/01/00 to 12/31/00
Outputs
The Center for Comparative Medicine (CCM) at the University of California Davis is a collaboration between faculty in the School of Veterinary Medicine, School of Medicine and the California Regional Primate Research Center. The CCM provides a novel environment for research center training in comparative medicine. The primary CCM research mission is the investigation of host-agent interactions during persistent infectious diseases common to humans and animals. The CCM also serves as the academic home for laboratory animal sciences and medicine on campus. A major focus of the CCM mission is research training at the predoctoral, graduate and postdoctoral levels. Over 20 faculty have ongoing research projects at the CCM. Some of the research projects being investigated at the present time include: mouse model of tick- borne Lyme disease and granulocytic ehrlichiosis; tick-borne babesiosis and other protozoan diseases; bartonelloses with an international perspective;
transgenic pathology; geonomics; viral oncology; tropical infectious diseases; primate infectious diseases, antiviral strategies in SIV, HIV, FIV, herpes virus and fish diseases, among other projects.
Impacts
The ongoing primary CCM research mission is the investigation of host-agent interactions during persistent infectious diseases common to humans and animals.
Publications
- A complete list of publications for 1999 may be obtained from the Center for Comparative Medicine, School of Veterinary Medicine, University of California Davis, Davis California.
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Progress 01/01/99 to 12/31/99
Outputs
The Center for Comparative Medicine (CCM) at the University of California Davis is a collaboration between faculty in the School of Veterinary Medicine, School of Medicine and the California Regional Primate Research Center. The CCM provides a novel environment for research center training in comparative medicine. The primary CCM research mission is the investigation of host-agent interactions during persistent infectious diseases common to humans and animals. The CCM also serves as the academic home for laboratory animal sciences and medicine on campus. A major focus of the CCM mission is research training at the predoctoral, graduate and postdoctoral levels. Over 20 faculty have ongoing research projects at the CCM. Some of the research projects being investigated at the present time include: mouse model of tick- borne Lyme disease and granulocytic ehrlichiosis; tick-borne babesiosis and other protozoan diseases; bartonelloses with an international perspective;
transgenic pathology; geonomics; viral oncology; tropical infectious diseases; primate infectious diseases, antiviral strategies in SIV, HIV, FIV, herpes virus and fish diseases, among other projects.
Impacts
The ongoing primary CCM research mission is the investigation of host-agent interactions during persistent infectious diseases common to humans and animals.
Publications
- A complete list of publications for 1999 may be obtained from the Center for Comparative Medicine, School of Veterinary Medicine, University of California Davis, Davis California.
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Progress 01/01/98 to 12/31/98
Outputs
Funding for this project and all subsequent activities support the Center for Comparative Medicine at the University of California, Davis. The new Center represents a collaborative effort by faculty members from the medical and veterinary schools and the adjacent California Regional Primate Research Center. In addressing the pathogenesis of persistent viral infections and chronic viral diseases, the Center will emphasize three promising areas: transgenics and the optimization of gene transfer methodologies based on direct DNA injection and encapsulation of DNA into liposomes; development and evaluation of anti-retrovirus drugs; an studies of biological response modifiers, particularly the roles of various cytokines in antiviral immune responses.
Impacts
(N/A)
Publications
- A complete listing of publications for 1998 may be obtained from the Center for Comparative Medicine, School of Veterinary Medicine, University of California Davis.
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