Source: CORNELL UNIVERSITY submitted to NRP
SUDDEN DEATH IN YOUNG DOGS WITH VENTRICULAR ARRHYTHMIAS
Sponsoring Institution
Cooperating Schools of Veterinary Medicine
Project Status
EXTENDED
Funding Source
STATE
Reporting Frequency
Annual
Accession No.
0156807
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
Sep 30, 1991
Project End Date
Dec 31, 2009
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
CORNELL UNIVERSITY
(N/A)
ITHACA,NY 14853
Performing Department
CLINICAL SCIENCE
Non Technical Summary
(N/A)
Animal Health Component
50%
Research Effort Categories
Basic
50%
Applied
50%
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
3033899108025%
3033899102025%
3053899108025%
3053899102025%
Knowledge Area
303 - Genetic Improvement of Animals; 305 - Animal Physiological Processes;

Subject Of Investigation
3899 - Other animals, general;

Field Of Science
1080 - Genetics; 1020 - Physiology;
Goals / Objectives
Ascertain the temporal evolution of the spontaneous ventricular arrhythmia in affected dogs aged 4 weeks to 2 years, using 24-hour ambulatory electrocardiographic monitoring (Holter recordings). Determine if the spontaneous arrhythmia is exacerbated during sleep, using Holter monitoring in conjunction with simultaneous time-lapsed video recordings.
Project Methods
Determine if selected electrophysiologic indices are consistent with a suspectedautonomic imbalance. In that regard, we will: Determine if the corrected QT interval (QTc) is prolonged during sleep in affected dogs but not in unaffected, control dogs of the same breed. Compare heart rate variability during wakefulness and sleep in affected dogs that die versus those that survive, using Holter recordings. Determine if selected electrophysiological properties (e.g., atrial and ventricular refractory periods, AV conduction times) of affected dogs are abnormal, if the arrhythmia can be induced with programmed-stimulation protocols, and if arrhythmias occur with or without autonomic blockade and programmed stimulation when compared to unaffected control dogs. Determine if selected anatomical indices are consistent with an autonomic imbalance. In that regard, we will: Determine (noninvasively) if the distribution of PGyDTl-labeled metaiodobenzyl-quanidine (MIBG) uptake into sympathetic nerves is different in affected versus unaffected animals.