NEUROBIOLOGY RESEARCH - WASHINGTON STATE UNIVERSITY

Knowledge Area (KA)	Subject of Investigation (SOI)	Field of Science (FOS)	Percent
311	3999	1160	20%
305	3999	1000	80%

Progress 10/01/16 to 09/30/17

Outputs
Target Audience:Scientists and Veterinarians Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest?Gain of knowledge and dissemination of information via peer reviewed publications. What do you plan to do during the next reporting period to accomplish the goals?Continue gathering publications data for next reporting period.

Impacts
What was accomplished under these goals? This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is generally detailed in publications produced during this report period.

Publications

Type: Journal Articles Status: Published Year Published: 2017 Citation: Alcaro A, Carta S, Panksepp J. 2017. The Affective Core of the Self: A Neuro-Archetypical Perspective on the Foundations of Human (and Animal) Subjectivity. Frontiers in Psychology 8. Arguello AA, Richardson BD, Hall JL, Wang R, Hodges MA, Mitchell MP, Stuber GD, Rossi DJ, Fuchs RA. 2017. Role of a Lateral Orbital Frontal Cortex-Basolateral Amygdala Circuit in Cue-Induced Cocaine-Seeking Behavior. Neuropsychopharmacology 42:727-735. Arguello AA, Wang R, Lyons CM, Higginbotham JA, Hodges MA, Fuchs RA. 2017. Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats. Psychopharmacology 234:2431-2441. Baxter-Potter LN, Henricks AM, Berger AL, Bieniasz KV, Lugo JM, McLaughlin RJ. 2017. ALCOHOL VAPOR EXPOSURE DIFFERENTIALLY IMPACTS MESOCORTICOLIMBIC CYTOKINE EXPRESSION IN A SEX-, REGION-, AND DURATION-SPECIFIC MANNER. Neuroscience 346:238-246. Blacktop JM, Todd RP, Sorg BA. 2017. Role of perineuronal nets in the anterior dorsal lateral hypothalamic area in the acquisition of cocaine-induced conditioned place preference and self-administration. Neuropharmacology 118:124-136. Burgdorf J, Colechio EM, Stanton P, Panksepp J. 2017. Positive Emotional Learning Induces Resilience to Depression: A Role for NMDA Receptor-mediated Synaptic Plasticity. Current Neuropharmacology 15:3-10. Chakravorty S, Tanner BCW, Foelber VL, Vu H, Rosenthal M, Ruiz T, Vigoreaux JO. 2017. Flightin maintains myofilament lattice organization required for optimal flight power and courtship song quality in Drosophila. Proceedings of the Royal Society B-Biological Sciences 284. Chen YJ, Tokuda JM, Topping T, Meisburger SP, Pabit SA, Gloss LM, Pollack L. 2017. Asymmetric unwrapping of nucleosomal DNA propagates asymmetric opening and dissociation of the histone core. Proceedings of the National Academy of Sciences of the United States of America 114:334-339. Choi JA, Wyrick JJ. 2017. RegulatorDB: a resource for the analysis of yeast transcriptional regulation. Database-the Journal of Biological Databases and Curation doi:10.1093/database/bax058. Cleary K, Skornyakov E. 2017. Predicting falls in older adults using the four square step test. Physiotherapy Theory and Practice 33:766-771. Colburn ZT, Jones JCR. 2017. alpha(6)beta(4) Integrin Regulates the Collective Migration of Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 56:443-452. Court MH, Zhu ZH, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ. 2017. Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers. Journal of Pharmacology and Experimental Therapeutics 362:431-440. Cuttler C, Spradlin A, Nusbaum AT, Whitney P, Hinson JM, McLaughlin RJ. 2017. Blunted stress reactivity in chronic cannabis users. Psychopharmacology 234:2299-2309. Dixon A, Fauber AE. 2017. Effect of anesthesia-associated hypotension on neurologic outcome in dogs undergoing hemilaminectomy because of acute, severe thoracolumbar intervertebral disk herniation: 56 cases (2007-2013). Javma-Journal of the American Veterinary Medical Association 250:417-423. Felix RA, Elde CJ, Nevue AA, Portfors CV. 2017. Serotonin modulates response properties of neurons in the dorsal cochlear nucleus of the mouse. Hearing Research 344:13-23. Fernandez-Vargas M. 2017. Rapid effects of estrogens and androgens on temporal and spectral features in ultrasonic vocalizations. Hormones and Behavior 94:69-83. Fowler DK, Peters JH, Williams C, Washbourne P. 2017. Redundant Postsynaptic Functions of SynCAMs 1-3 during Synapse Formation. Frontiers in Molecular Neuroscience 10.
Type: Journal Articles Status: Published Year Published: 2017 Citation: Henricks AM, Berger AL, Lugo JM, Baxter-Potter LN, Bieniasz KV, Petrie G, Sticht MA, Hill MN, McLaughlin RJ. 2017. Sex- and hormone-dependent alterations in alcohol withdrawal-induced anxiety and corticolimbic endocannabinoid signaling. Neuropharmacology 124:121-133. Hrubec TC, Melin VE, Shea CS, Ferguson EE, Garofola C, Repine CM, Chapman TW, Patel HR, Razvi RM, Sugrue JE, Potineni H, Magnin-Bissel G, Hunt PA. 2017. Ambient and Dosed Exposure to Quaternary Ammonium Disinfectants Causes Neural Tube Defects in Rodents. Birth Defects Research 109:1166-1178. Hutson LW, Lebonville CL, Jones ME, Fuchs RA, Lysle DT. 2017. Interleukin-1 signaling in the basolateral amygdala is necessary for heroin-conditioned immunosuppression. Brain Behavior and Immunity 62:171-179. Ivezaj V, Stoeckel LE, Avena NM, Benoit SC, Conason A, Davis JF, Gearhardt AN, Goldman R, Mitchell JE, Ochner CN, Saules KK, Steffen KJ, Stice E, Sogg S. 2017. Obesity and addiction: can a complication of surgery help us understand the connection? Obesity Reviews 18:765-775. Jensen JP, Nipper MA, Helms ML, Ford MM, Crabbe JC, Rossi DJ, Finn DA. 2017. Ethanol withdrawal-induced dysregulation of neurosteroid levels in plasma, cortex, and hippocampus in genetic animal models of high and low withdrawal. Psychopharmacology 234:2793-2811. Madden Ellsworth L, Keen HA, Mills PE, Newman J, Martin F, Coffey T, Newberry RC. 2017. Role of 4-H Dog Programs in Life Skills Development. Anthrozoos 30:91-108. Montag C, Panksepp J. 2017. Primary Emotional Systems and Personality: An Evolutionary Perspective. Frontiers in Psychology 8. Montag C, Widenhorn-Muller K, Panksepp J, Kiefer M. 2017. Individual differences in Affective Neuroscience Personality Scale (ANPS) primary emotional traits and depressive tendencies. Comprehensive Psychiatry 73:136-142. Neveux S, Smith NK, Roche A, Blough BE, Pathmasiri W, Coffin AB. 2017. Natural Compounds as Occult Ototoxins? Ginkgo biloba Flavonoids Moderately Damage Lateral Line Hair Cells. Jaro-Journal of the Association for Research in Otolaryngology 18:275-289. Nusbaum AT, Whitney P, Cuttler C, Spradlin A, Hinson JM, McLaughlin RJ. 2017. Altered attentional control strategies but spared executive functioning in chronic cannabis users. Drug and Alcohol Dependence 181:116-123. Offerdahl EG, Arneson JB, Byrne N. 2017. Lighten the Load: Scaffolding Visual Literacy in Biochemistry and Molecular Biology. Cbe-Life Sciences Education 16. Pagano AM, Rode KD, Cutting A, Owen MA, Jensen S, Ware JV, Robbins CT, Durner GM, Atwood TC, Obbard ME, Middel KR, Thiemann GW, Williams TM. 2017. Using tri-axial accelerometers to identify wild polar bear behaviors. Endangered Species Research 32:19-33. Panksepp J, Lane RD, Solms M, Smith R. 2017. Reconciling cognitive and affective neuroscience perspectives on the brain basis of emotional experience. Neuroscience and Biobehavioral Reviews 76:187-215. Perez TE, Mealey KL, Burke NS, Grubb TL, Court MH, Greene SA. 2017. Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs. Veterinary Anaesthesia and Analgesia 44:370-374. Richardson BD, Rossi DJ. 2017. Recreational concentrations of alcohol enhance synaptic inhibition of cerebellar unipolar brush cells via pre- and postsynaptic mechanisms. Journal of Neurophysiology 118:267-279. Roberts BL, Zhu MY, Zhao H, Dillon C, Appleyard SM. 2017. High glucose increases action potential firing of catecholamine neurons in the nucleus of the solitary tract by increasing spontaneous glutamate inputs. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 313:R229-R239.
Type: Journal Articles Status: Published Year Published: 2017 Citation: Rougemont-Bucking A, Gamma F, Panksepp J. 2017. Use of tramadol in psychiatric care: a comprehensive review and report of two cases. Swiss Medical Weekly 147. Sattler SA, Walker AM, Vermerris W, Sattler SE, Kang C. 2017. Structural and Biochemical Characterization of Cinnamoyl-CoA Reductases. Plant Physiology 173:1031-1044. Sirohi S, Richardson B, Lugo JM, Rossi DJ, Davis JF. 2017. Impact of Roux-en-Y gastric bypass surgery on appetite, alcohol intake behaviors, and midbrain ghrelin signaling in the rat. Obesity 25:1228-1236. Sirohi S, Van Cleef A, Davis J. 2017. Patterned feeding induces neuroendocrine, behavioral and genetic changes that promote palatable food intake. International Journal of Obesity 41:412-419. Sirohi S, Van Cleef A, Davis JF. 2017. Binge-like intake of HFD attenuates alcohol intake in rats. Physiology & Behavior 178:187-195. Sirohi S, Van Cleef A, Davis JF. 2017. Intermittent access to a nutritionally complete high-fat diet attenuates alcohol drinking in rats. Pharmacology Biochemistry and Behavior 153:105-115. Skovira EJ, Behrend EN, Martin LG, Palmer LE, Kemppainen RJ, Lee HP. 2017. Effect of laparotomy on the pituitary-adrenal axis in dogs. American Journal of Veterinary Research 78:919-925. Somasundaram P, Wyrick GR, Fernandez DC, Ghahari A, Pinhal CM, Richardson MS, Rupp AC, Cui LH, Wu ZJ, Brown RL, Badea TC, Hattar S, Robinson PR. 2017. C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice. Proceedings of the National Academy of Sciences of the United States of America 114:2741-2746. Song Y, Du D, Li L, Xu J, Dutta P, Lin YH. 2017. In Vitro Study of Receptor-Mediated Silica Nanoparticles Delivery across Blood-Brain Barrier. Acs Applied Materials & Interfaces 9:20410-20416. Stringfield J, Higginbotham JA, Wang R, Berger AL, McLaughlin R, Fuchs RA. 2017. Role of glucocorticoid receptor-mediated mechanisms in cocaine memory enhancement. Neuropharmacology 123:349-358. Suarez MA, Seddighi R, Egger CM, Rohrbach BW, Cox SK, KuKanich BK, Doherty TJ. 2017. Effect of fentanyl and lidocaine on the end-tidal sevoflurane concentration preventing motor movement in dogs. American Journal of Veterinary Research 78:12-16. Vaughn AC, Cooper EM, DiLorenzo PM, OLoughlin LJ, Konkel ME, Peters JH, Hajnal A, Sens T, Lee SH, de La Serre CB, Czaja K. 2017. Energy-dense diet triggers changes in gut microbiota, reorganization of gut-brain vagal communication and increases body fat accumulation. Acta Neurobiologiae Experimentalis 77:18-30. Ware JV, Rode KD, Bromaghin JF, Douglas DC, Wilson RR, Regehr EV, Amstrup SC, Durner GM, Pagano AM, Olson J, Robbins CT, Jansen HT. 2017. Habitat degradation affects the summer activity of polar bears. Oecologia 184:87-99. Waroff AJ, Fanucchi L, Robbins CT, Nelson OL. 2017. Tool use, problem-solving, and the display of stereotypic behaviors in the brown bear (Ursus arctos). Journal of Veterinary Behavior-Clinical Applications and Research 17:62-68. Wiedenhoft H, Hayashi L, Coffin AB. 2017. PI3K and Inhibitor of Apoptosis Proteins Modulate Gentamicin-Induced Hair Cell Death in the Zebrafish Lateral Line. Frontiers in Cellular Neuroscience 11. Wu SW, Fowler DK, Shaffer FJ, Lindberg JEM, Peters JH. 2017. Ethyl Vanillin Activates TRPA1. Journal of Pharmacology and Experimental Therapeutics 362:368-377.

Progress 10/01/15 to 09/30/16

Outputs
Target Audience:Scientists and Veterinarians. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest?Gain of knowledge and dissemination of information via peer reviewed publications. What do you plan to do during the next reporting period to accomplish the goals?Continue gathering publications data for the next reporting period.

Impacts
What was accomplished under these goals? This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications produced during the report period.

Publications

Type: Journal Articles Status: Published Year Published: 2016 Citation: Montag C, Widenhorn-M�ller K, Panksepp J, Kiefer M. (2016). Individual differences in Affective Neuroscience Personality Scale (ANPS) primary emotional traits and depressive tendencies. Compr Psychiatry. 73:136-142. doi: 10.1016/j.comppsych.2016.11.007. Audrey M Wells, Xiaohu Xie, Jessica A Higginbotham, Amy A Arguello, Kati L Healey, Megan Blanton, and Rita A Fuchs (2016). Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats. Neuropsychopharmacology, 41, 675685; doi:10.1038/npp.2015.217; published online 12 August 2015 PMCID: PMC4707834 [Available on 2017-02-01] Guo R, Simasko SM, Jansen HT (2016). Chronic Alcohol Consumption in Rats Leads to Desynchrony in Diurnal Rhythms and Molecular Clocks. Alcohol Clin Exp Res. 40(2):291-300. doi: 10.1111/acer.12944. PMID: 26842248 Sirohi S, Schurdak JD, Seeley RJ, Benoit SC, Davis JF (2016). Central & peripheral glucagon-like peptide-1 receptor signaling differentially regulate addictive behaviors. Physiol Behav. 161:140-4. doi: 10.1016/j.physbeh.2016.04.013. Epub 2016 Apr 9. PMID: 27072507 Matthew Kruger, Robert Boney, Alexander J. Ordoobadi, Thomas F. Sommers, Josef G. Trapani and Allison B. Coffin (2016). Natural Bizbenzoquinoline Derivatives Protect Zebrafish Lateral Line Sensory Hair Cells from Aminoglycoside Toxicity. Front. Cell. Neurosci. http://dx.doi.org/10.3389/fncel.2016.00083PMCID: PMC4811916 Gollapudi SK, Chandra M (2016). The effect of cardiomyopathy mutation (R97L) in mouse cardiac troponin T on the muscle length-mediated recruitment of crossbridges is modified divergently by ?- and ?-myosin heavy chain. Arch Biochem Biophys. 601:105-12. doi: 10.1016/j.abb.2016.01.008. Epub 2016 Jan 11. PMCID: PMC4899193 Hannah C. Pulcastro, Peter O. Awinda, Mei Methawasin, Henk Granzier , Wenji Dong and Bertrand C.W. Tanner (2016). Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm20?RRM Mice. Front. Physiol. http://dx.doi.org/10.3389/fphys.2016.00322 PMCID: PMC4966298 Fenwick A., Leighton S., Tanner Bertrand C.W. (2016), Myosin MgADP Release Rate Decreases as Sarcomere Length Increases in Skinned Rat Soleus Muscle Fibers, Biophysical Journal, http://dx.doi.org/10.1016/j.bpj.2016.09.024 PMID: 26475586
Type: Journal Articles Status: Published Year Published: 2016 Citation: Yovell Y, Bar G, Mashiah M., Baruch, Y., Briskman, I., Asherov, J., Lotan, A., Rigbi, A., & Panksepp, J. (2016). Ultra-low-dose buprenorphine as a time-limited treatment for severe suicidal ideation: a randomized, controlled trial. American Journal of Psychiatry. 173, 491-498. Panksepp, J. (2016). The cross mammalian neurophenomenology of primal emotional affects: From animal feelings to human therapeutics. Journal of Comparative Neurology. 524(8):1624-35. Karterud S, Pedersen G, Johansen M, Wilberg T, Davis K, Panksepp J. (2016). Primary emotional traits in patients with personality disorders. Personal Mental Health Burgdorf, J., Colechio, E.M., Stanton, P., Panksepp, J. (2016). Positive emotional learning induces resilience to depression: a role of synaptic plasticity. Montag C, Hahn E, Reuter M, Spinath FM, Davis K, Panksepp J. (2016). The role of nature and nurture for individual differences in primary emotional systems: Evidence from a twin study. PLoS One. 11(3):e0151405. doi: 10.1371/journal.pone.0151405. eCollection 2016. Erratum in: PLoS One. 2016;11(6):e0157200. Montag, C. & Panksepp, J. (2016). Primal emotional-affective expressive foundations of human facial expression. Motivation and Emotion, In press. Joshua S. Kaplan, Claudia Mohr, Caroline M. Hostetler, Andrey E. Ryabinin, Deborah A. Finn, and David J. Rossi. Alcohol Suppresses Tonic GABAA Receptor Currents in Cerebellar Granule Cells in the Prairie Vole: A Neural Signature of High-Alcohol-Consuming Genotypes. Laeng, B., Eidet, L.M., Sulutvedt, U. & Panksepp, J. (2016). Music chills: The eye pupil as a mirror to musics soul. Consciousness & Cognition, 44:161-178. doi: 10.1016/j.concog.2016.07.009. Henricks, A.M., Berger, A.L., Lugo, J.M., Baxter-Potter, L.N., Bieniasz, K.V., Craft, R.M., McLaughlin, R.J. (in press). Sex differences in alcohol consumption and alterations in nucleus accumbens endocannabinoid mRNA in alcohol- dependent rats. Fuchs, R.A., McLaughlin, R.J. (2016). Garcinol: A Magic Bullet of Amnesia for Maladaptive Memories? Neuropsychopharmacology De Gregorio, D., Posa, L., Ochoa-Sanchez, R., McLaughlin, R.J., Maione, S., Comai, S., Gobbi, G. (in press). The hallucinogen D-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2, and TAAR1 receptors. Pharmacological Research, xx, xx-xx. doi:10.1016/j.phrs.2016.08.022 Mulvaney JF, Thompkins C, Noda T, Nishimura K, Sun WW, Lin S-Y, Coffin A, Dabdoub A (2016) Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line. Scientific Reports. 6:31668. doi: 10.1038/srep31668. Smith ME, Groves AK, Coffin AB (2016) Editorial: Sensory hair cell death and regeneration. Frontiers in Cellular Neuroscience DOI: 10.3389/fncel.2016.00208. Monroe JD, Manning DP, Uribe PM, Bhandiwad A, Sisneros JA, Smith ME, Coffin AB (in press) Hearing sensitivity differs between zebrafish lines used in auditory research. Hearing Research Arguello AA, Richardson BD, Hall JL, Wang R, Hodges MA, Mitchell MP, Stuber GD, Rossi DJ, Fuchs RA. Role of a Lateral Orbital Frontal Cortex-Basolateral Amygdala Circuit in Cue-Induced Cocaine-Seeking Behavior. Neuropsychopharmacology. 2016 Sep 21. doi: 10.1038/npp.2016.157. [Epub ahead of print] Stringfield SJ, Higginbotham JA, Fuchs RA. Requisite Role of Basolateral Amygdala Glucocorticoid Receptor Stimulation in Drug Context-Induced Cocaine-Seeking Behavior. Int J Neuropsychopharmacol. 2016 Sep 15. pii: pyw073. doi: 10.1093/ijnp/pyw073. [Epub ahead of print] Lebonville CL, Jones ME, Hutson LW, Cooper LB, Fuchs RA, Lysle DT. Acquisition of heroin conditioned immunosuppression requires IL-1 signaling in the dorsal hippocampus. Brain Behav Immun. 2016 Aug;56:325-34. doi: 10.1016/j.bbi.2016.04.005. Epub 2016 Apr 9
Type: Journal Articles Status: Published Year Published: 2016 Citation: Sirohi S, Van Cleef A, Davis JF. Binge-like intake of HFD attenuates alcohol intake in rats. Physiol Behav. 2016 Oct 17. pii: S0031-9384(16)30599-6. doi: 10.1016/j.physbeh.2016.10.006. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/27765644 Davis CJ, Taishi P, Honn KA, Koberstein JN, Krueger JM. (in press) P2X7 receptors in body temperature, locomotor activity, and brain mRNA and lncRNA responses to sleep loss. Am. J. Physiology. (Accepted) Panksepp, J. & Wilson, C.G. (2016). Brain SEEKING Circuitry in Neuroeconomics: A Unifying Hypothesis for the Role of Dopamine-Energized Arousal of the Medial Forebrain Bundle in Enthusiasm-Guiding Decision-Making. In Neuroeconomics (Studies in Neuroscience, Psychology and Behavioral Economics Series). Reuter, M. & Montag, C. (editors). pp. 231-152. Springer: Berlin. Panksepp, J. (2016) The Psycho-Neurology of Cross-Species Affective/Social Neuroscience: Understanding Animal Affective States as a Guide to Development of Novel Psychiatric Treatments. Curr Top Behav Neurosci. 2016 Oct 2. [Epub ahead of print] Panksepp J, Lane RD, Solms M, Smith R. (2016). Reconciling cognitive and affective neuroscience perspectives on the brain basis of emotional experience. Neurosci Biobehav Rev. 2016 Sep 15. pii: S0149-7634(16)30150-6. doi: 10.1016/j.neubiorev.2016.09.010. [Epub ahead of print] Karterud S, Pedersen G, Johansen M, Wilberg T, Davis K, Panksepp J. (2016). Primary emotional traits in patients with personality disorders. Personality and Mental Health. 10: 261-273. doi: 10.1002/pmh.1345. Montag, C. & Panksepp, J. (2016). Primal emotional-affective expressive foundations of human facial expression Motivation and Emotion, 40: 760-766. Sunil Sirohia, Arriel Van Cleef, Jon F. Davis. Intermittent access to a nutritionally complete highfat diet attenuates alcohol drinking in rats. Pharmacology Biochemistry and Behavior (In Press). http://dx.doi.org/10.1016/j.pbb.2016.12.009 Sunil Sirohi, Arriel VanCleef, and Jon Davis. Patterned Feeding Induces Neuroendocrine, Behavioral, and Genetic Changes that Promote Palatable Food Intake. International Journal of Obesity (Accepted). Panksepp J, Lane RD, Solms M, Smith R. (2016). Reconciling cognitive and affective neuroscience perspectives on the brain basis of emotional experience. Neurosci Biobehav Rev. pii: S0149-7634(16)30150-6. doi: 10.1016/j.neubiorev.2016.09.010.

Progress 10/01/14 to 09/30/15

Outputs
Target Audience:Scientists and Veterinarians. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest?Gain of knowledge and dissemination of information via peer reviewed publications. What do you plan to do during the next reporting period to accomplish the goals?Continue gathering publications data for next reporting period.

Impacts
What was accomplished under these goals? This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progree in the project is detailed in the publications produced during the report period.

Publications

Type: Journal Articles Status: Published Year Published: 2015 Citation: Lee J, Dykstra B, Sackstein R, Rossi DJ. Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells. Curr Opin Hematol. 2015 Jul;22(4):317-23. doi: 10.1097/MOH.0000000000000147. PMID: 26049752 Li AJ, Wang Q, Elsarelli MM, Brown RL, and Ritter S. Hindbrain Catecholamine Neurons Activate Orexin Neurons During Systemic Glucoprivation in Male Rats. Endocrinology 156: 2807-2820, 2015. Li AJ, Wang Q, Davis H, Wang R, and Ritter S. Orexin-A enhances feeding in male rats by activating hindbrain catecholamine neurons. Am J Physiol Regul Integr Comp Physiol 309: R358-367, 2015 Li AJ, Wang Q, Dinh TT, Simasko SM, Ritter S. Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 20:ajpregu.00387.2015. doi: 10.1152/ajpregu.00387.2015. [Epub ahead of print] PMID: 26791830 McLaughlin, R.J., Verlezza, S., Gray, J.M., Hill, M.N., Walker, C.D. (2016). Inhibition of anandamide hydrolysis dampens the neuroendocrine response to stress in neonatal rats subjected to suboptimal rearing conditions. Stress, 19(1), 114-124. Meighan PC, Peng C, Varnum MD. Inherited macular degeneration-associated mutations in CNGB3 increase the ligand sensitivity and spontaneous open probability of cone cyclic nucleotide-gated channels. Front Physiol. 2015 Jun 9;6:177. doi: 10.3389/fphys.2015.00177. eCollection 2015. PMID: 26106334 Monreal IA, Liu Q, Tyson K, Bland T, Dalisay DS, Adams EV, Wayman GA, Aguilar HC, Saludes JP. Branched dimerization of Tat peptide improves permeability to HeLa and hippocampal neuronal cells. Chem Commun (Camb). 2015 Mar 28;51 (25):5463-6. Obici S, Magrisso IJ, Ghazarian AS, Shirazian A, Miller JR, Loyd CM, Begg DP, Krawczewski Carhuatanta KA, Haas MK, Davis JF, Woods SC, Sandoval DA, Seeley RJ, Goodyear LJ, Pothos EN, Mul JD. Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation. Mol Metab. 2015 Jul 17;4(10):692-705. doi: 10.1016/j.molmet.2015.07.003. eCollection 2015. Phillips, D.P., Savenkova, M., Karatsoreos, I.N. (2015) Environmental disruption of the circadian clock leads to altered sleep and immune responses in mouse. Brain, Behavior, and Immunity. Jul; 47:14-23. PMID: 25542734. Pulcastro HC, Awinda PO, Breithaupt JJ, Tanner BCW. (In Press) Effects of myosin light chain phosphorylation on length-dependent myosin kinetics in skinned rat myocardium. Arch Biochem Biophys. doi: 10.1016/j.abb.2015.12.014. Slaker M, Churchill L, Todd RP, Blacktop JM, Zuloaga DG, Raber J, Darling RA, Brown TE, Sorg BA. Removal of perineuronal nets in the medial prefrontal cortex impairs the acquisition and reconsolidation of a cocaine-induced conditioned place preference memory. J Neurosci. 2015 Mar 11; 35(10):4190-202. Sorg BA, Todd RP, Slaker M, Churchill L. Anisomycin in the medial prefrontal cortex reduces reconsolidation of cocaine-associated memories in the rat self-administration model. Neuropharmacology. 2015 May; 92:25-33. Xiong WH, Brown RL, Reed B, Burke NS, Duvoisin RM, et al. Voriconazole, an antifungal triazol that causes visual side effects, is an inhibitor of TRPM1 and TRPM3 channels. Investigative ophthalmology & visual science. 2015; 56(2):1367-73. PMCID: PMC4340431 Zhao H, Peters JH, Zhu M, Page SJ, Ritter RC, Appleyard SM. Frequency-dependent facilitation of synaptic throughput via postsynaptic NMDA receptors in the nucleus of the solitary tract. J Physiol. 2015 Jan 1;593(1):111-25. doi: 10.1113/jphysiol.2013.258103. Epub 2014 Nov 3. PMID: 25281729
Type: Journal Articles Status: Published Year Published: 2015 Citation: M.J. Lambert, W.O. Cochran, B.M. Wilde, K.G. Olsen and C.D. Cooper (2015) Evidence for widespread subfunctionalization of splice forms in vertebrate genomes. Genome Res 25(5): 624-32. Her, S.C. and Her, C.: Targeting DNA Double-strand Break Repair in Cancer Therapy. J Mol Genet Med 9:4, 2015,1000E106 Xu, Y. and Her, C.: Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy. Biomolecules. 2015 Jul 22;5(3):1652-70. doi: 10.3390/biom5031652. Review. PMID: 26287259 Xu, Y., Wu, X., and Her, C.: hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ. J. Biol. Chem. 2015 Jul 24;290(30):18545-58. doi: 10.1074/jbc.M115.642884. Epub 2015 Jun 8. PMID: 26055704 Her, C.: Versatility of DNA Double Strand Break Repair. J Mol Genet Med 9:2, 2015, 1000E103 Jia, P., Her, C., and Chai, W.: DNA excision repair at telomeres. DNA Repair (Amst). 2015 Sep 16. pii: S1568-7864(15)00192-5. doi: 10.1016/j.dnarep.2015.09.017. [Epub ahead of print] Review. PMID: 26422132 Quinnies KM, Doyle TJ, Kim KH, Rissman EF. Transgenerational effects of di-(2-ethylhexyl) phthalate, DEHP on stress hormones and behavior. Endocrinology 2015; 156:3077-3083. PMID: 26208959 Wyrick, John J. and Roberts, Steven A. (2015) Genomic Approaches to DNA repair and Mutagenesis. DNA Repair. S1568-7864(15)00193-7. doi: 10.1016/j.dnarep.2015.09.018. [Epub ahead of print]. PMID: 26411877 Kazanov, M.D., Roberts, S.A., Polak, P., Stamatoyannopoulos, J., Klimczak, L.J., Gordenin, D.A., Sunyaev, S.R. (2015) APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions. Cell Reports. 13(6):1103-9. doi: 10.1016/j.celrep.2015.09.077. Epub 2015 Oct 29. PMID: 26527001 Chan, K., Roberts, S.A., Klimczak, L.J., Sterling, J.F., Saini, N., Malc, E.P., Kim, J., Kwiatkowski, D.J., Fargo, D., Mieczkowski, P.A., Getz, G., and Gordenin, D.A., (2015) An APOBEC3A hypermutation signature is10.1038/ng.3378. Epub 2015 Aug 10. PMID: 26258849 distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers. Nature Genetics. 47(9):1067-72. doi: Abnormal retinal development in Cloche mutant zebrafish. Dhakal S, Stevens CB, Sebbagh M, Weiss O, Frey RA, Adamson S, Shelden EA, Inbal A, Stenkamp DL. Dev Dyn. 2015 Nov;244(11):1439-55. doi: 10.1002/dvdy.24322. Epub 2015 Sep 2 Meas, R., Smerdon, M. J. and Wyrick, J. J. The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling, and postreplication repair in Saccharomyces cerevisiae, Nucleic Acids Res. 43: 4990-5001, 2015. Marshall Deline, Julia Keller, Michael Rothe, Wolf-Hagen Schunck, Ralph Menzel, Jennifer L. Watts (2015). Epoxides Derived from Dietary Dihomo-Gamma-Linolenic Acid Induce Germ Cell Death in C. elegans Scientific Reports 5:15417 | DOI: 10.1038/srep15417. Laughery, M.F., Hunter, T., Brown, A., Hoopes, J., Ostbye, T., Shumaker, T. and Wyrick, J.J. (2015) New vectors for simple and streamlined CRISPR-Cas9 genome editing in Saccharomyces cerevisiae. Yeast, 32:711-720. Wyrick, J.J. and Roberts, S.A. (2015) Genomic approaches to DNA repair and mutagenesis. DNA repair, 36:146-155. Xia Y., W. Chu, Q. Qi, and L. Xun*. 2015. New insights into the QuikChangeTM process guide the use of Phusion DNA polymerase for site-directed mutagenesis. Nucleic Acids Res. 30;43(2):e12. doi: 10.1093/nar/gku1189. Beerman I, Rossi DJ. Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. Cell Stem Cell. 2015 Jun 4;16(6):613-25. doi: 10.1016/j.stem.2015.05.009. Review. PMID: 26046761
Type: Journal Articles Status: Published Year Published: 2015 Citation: Bocarsly, M.E., Fasolino, M., Kane, G.A., LaMarca, E.A., Kirschen, G., Karatsoreos, I.N., McEwen, B.S., Gould, E. (2015) Obesity diminishes synaptic markers, alters microglial morphology and impairs cognitive function. Proceedings of the National Academy of Sciences. 112(51):15731-6. PMID: 26644559 Bowles, N., Karatsoreos, I.N., Li, X., Vemuri, V.K., Wood, J., Li, Z., Tamashiro, K., Schwartz, G.J., Makriyannis, A.M., Kunos, G., Hillard, C.J., McEwen, B.S., Hill, M.N. (2015) A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proceedings of the National Academy of Science. 112(1):285-90. PMCID: PMC4291642. Brown, R.L., Xiong, W.-H., Peters, J.H., Tekmen-Clark, M., Strycharska-Orczyk, I., Reed, B.T., Morgans, C.W., Duvoisin, R.M. (2015) TRPM3 expression in mouse retina. PLoS ONE. 10 (2): e0117615-14 (PMC4334530). Campos CA, Ritter RC. NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R1-9. doi: 10.1152/ajpregu.00388.2014. Epub 2014 Nov 12. Ebina W, Rossi DJ. Transcription factor-mediated reprogramming toward hematopoietic stem cells. EMBO J. 2015 Mar 12;34(6):694-709. doi: 10.15252/embj.201490804. Epub 2015 Feb 20. Review. PMID: 25712209 Gehring JL, Rigano KS, Evans Hutzenbiler BD, Nelson OL, Robbins CT, Jansen HT. A protocol for the isolation and cultivation of brown bear (Ursus arctos) adipocytes. Cytotechnology. (IN PRESS) Gray, J.M., Vecchiarelli, H.A., Morena, M., Lee, T.T., Hermanson, D.J., Kim, A.B., McLaughlin, R.J., Hassan, K.I., Kuhne, C., Wotjak, C.T., Deussing, J.M., Patel, S., Hill, M.N. (2015). Corticotropin releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. Journal of Neuroscience, 35(9), 3879-3892. Gray, J.M., Wilson, C.D., Lee, T.T.Y., Pittman, Q.J., Deussing, J.M., Hillard, C.J., McEwen, B.S., Schulkin, J., Karatsoreos, I.N., Patel, S., Hill, M.N. (In Press). Sustained Glucocorticoid Exposure Recruits Cortico-limbic CRH Signaling to Modulate Endocannabinoid Function. Psychneuroendocrinology. Guo R, Simasko SM, Jansen HT. Chronic alcohol consumption in rats leads to desynchrony in diurnal rhythms and molecular clocks. Alc. Clin. Exp. Res. (IN PRESS). Hayashi L, Sheth M, Young A, Kruger M, Wayman GA, Coffin AB. The effect of the aquatic contaminants bisphenol-A and PCB-95 on the zebrafish lateral line. Neurotoxicology. 2015 Jan; 46:125-36. doi: 10.1016/j.neuro.2014.12.010. Epub 2014 Dec 31. Joyce-Zuniga N, Newberry R, Ware JV, Jansen HT, Robbins CT, Nelson OL. Positive Reinforcement Training of Medical Husbandry Behavior Results in No Elevation of Serum Cortisol in Grizzly Bears (Ursus arctos horribilis). Zoo Biol. (IN PRESS). Kaplowitz, E., Savenkova, M., Karatsoreos, I.N., Romeo, R.D. (2015) Somatic and neuroendocrine changes in response to chronic corticosterone exposure during adolescence in male and female rats. Journal of Neuroendocrinology. PMID: 26568535. E-pub ahead of print, November. Kinlein, S., Wilson, C.D., Savenkova, M., Karatsoreos, I.N. (2015) Disruption of HPA axis leads to divergent neurobehavioral responses to stress. Frontiers in Psychiatry. 6:31. PMID: 25821436.

Progress 10/01/13 to 09/30/14

Outputs
Target Audience:Scientists and Veterinarians. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest?Gain of knowledge and dissemination of information via peer reviewed publications. What do you plan to do during the next reporting period to accomplish the goals?Resume gathering publications data for next reporting period.

Impacts
What was accomplished under these goals? This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications produced during the report period, however publication data was not gathered during this reporting period.

Publications

Progress 01/01/13 to 09/30/13

Outputs
Target Audience:Scientists and veterinarians. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest?Gain of knowledge and dissemination of information via peer reviewed publications. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications.

Publications

Progress 01/01/12 to 12/31/12

Outputs
OUTPUTS: This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below: PARTICIPANTS: Not relevant to this project. TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Campos CA, Wright JS, Czaja K, Ritter RC. (2012) CCK-Induced Reduction of Food Intake and Hindbrain MAPK Signaling Are Mediated by NMDA Receptor Activation. Endocrinology 153, 2633-2646
Cui RJ, Roberts BL, Zhao H, Andresen MC, Appleyard SM. (2012) Opioids Inhibit Visceral Afferent Activation Of Catecholamine Neurons In The Solitary Tract Nucleus. Neuroscience 222, 181-190
Cui RJ, Roberts BL, Zhao H, Zhu MY, Appleyard SM. (2012) Serotonin Activates Catecholamine Neurons in the Solitary Tract Nucleus by Increasing Spontaneous Glutamate Inputs. Journal of Neuroscience 32, 16530-16538
Czaja K. (2012) The neural butterfly effect The injury to peripheral nerves changes the brain. Neural Regeneration Research 7, 1045-1046
Czaja K, Fornaro M, Geuna S. (2012) Neurogenesis in the adult peripheral nervous system. Neural Regeneration Research 7, 1047-1054
Gallaher ZR, Ryu V, Herzog T, Ritter RC, Czaja K. (2012) Changes in microglial activation within the hindbrain, nodose ganglia, and the spinal cord following subdiaphragmatic vagotomy. Neuroscience Letters 513, 31-36
Jahng JW, Yoo SB, Ryu V, Lee JH. (2012) Hyperphagia and depression-like behavior by adolescence social isolation in female rats. International Journal of Developmental Neuroscience 30, 47-53
Li AJ, Wiater MF, Oostrom MT, Smith BR, Wang Q, Dinh TT, Roberts BL, Jansen HT, Ritter S. (2012) Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 302, R1313-R1326
Ronchi G, Ryu V, Fornaro M, Czaja K. (2012) Hippocampal plasticity after a vagus nerve injury in the rat. Neural Regeneration Research 7, 1055-1063
Wayman, G. A., Yang, D. R., Bose, D. D., Lesiak, A., Ledoux, V., Bruun, D., Pessah, I. N., and Lein, P. J. (2012) PCB-95 Promotes Dendritic Growth via Ryanodine Receptor-Dependent Mechanisms. Environmental Health Perspectives 120, 997-1002
Zhang JC, Ritter RC. (2012) Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, nonvagal mechanisms. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 302, R264-R273

Progress 01/01/11 to 12/31/11

Outputs
OUTPUTS: This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below: PARTICIPANTS: Nothing significant to report during this reporting period. TARGET AUDIENCES: Nothing significant to report during this reporting period. PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Alcaro A, Panksepp J (2011). The SEEKING mind: Primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression. Neurosci Biobehav Rev, 35(9), 1805-1820. doi: 10.1016/j.neubiorev.2011.03.002
Ritter RC. 2011 Nov A tale of two endings: modulation of satiation by NMDA receptors on or near central and peripheral vagal afferent terminals. Physiol Behav. 30;105(1):94-9. Epub 2011 Mar 5. Review. PMID: 21382391
Sengupta P, Roy S, Krueger JM. (2011) The ATP-cytokine-adenosine hypothesis; How the brain translates past activity into sleep. Sleep and Biological Rhythms 9:29-33. PMCID: PMCID: PMC2980381
Benoist CC, Wright JW, Zhu M, Appleyard SM, Wayman GA, Harding JW. 2011 Oct Facilitation of hippocampal synaptogenesis and spatial memory by C-terminal truncated Nle1 angiotensin IV analogs. J Pharmacol Exp Ther 339(1):35-44. Epub 2011 Jun 30. PMID: 21719467
Burgdorf J, Panksepp J, Moskal JR (2011). Frequency-modulated 50kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect. Neurosci Biobehav Rev, 35(9), 1831-1836. doi: 10.1016/j.neubiorev.2010.11.011
Blasic JR Jr, Lane Brown R, Robinson PR. 2011. Light-dependent phosphorylation of the carboxy tail of mouse melanopsin. Cell Mol Life Sci. 2011 Dec 13. [Epub ahead of print] CZAJA, Krzysztof
Brown TE, Lee B, Mu P, Ferguson D, Dietz D, Ohnishi Y, Lin Y, Suska A, Ishikawa M, Huang Y, Shen HW, Kalivas PW, Sorg BA, Zukin RS, Nestler E, Dong Y, Schluter O (2011). A silent synapse-based mechanism for cocaine-induced locomotor sensitization J Neurosci 31:8163-8174.
Browning JR, Browning DA, Maxwell AO, Dong Y, Jansen HT, Panksepp J, Sorg BA. Neuropharmacology. 2011 Jul-Aug Positive affective vocalizations during cocaine and sucrose self-administration: a model for spontaneous drug desire in rats.61(1-2):268-75. Epub 2011 Apr 21. PMID: 21530553
Duricka DL, Brown RL, Varnum MD (2011). Defective trafficking of cone photoreceptor CNG channels induces the unfolded protein response, ER-stress-associated cell death. Biochem J. Jan 15, 441(2):685-96 PMID: 21992067
Fawley JA, Peters JH, Andresen MC (2011) GABAB-mediated inhibition of multiple modes of glutamate release in the nucleus of the solitary tract. Journal of Neurophysiology 106:1833-40. PMID: 21734101 PMCID: PMC3191834
Ferguson SM, Eskenazi D, Ishikawa M, Wanat MJ, Phillips PE, Dong Y, Roth BL, Neumaier JF. 2011 Jan Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nat Neurosci. 14(1):22-4. Epub 2010 Dec 5. PMID: 21131952
Gallaher ZR, Ryu V, Larios RT, Sprunger LK, Czaja K 2011. Neural proliferation and restoration of neurochemical phenotypes and compromised functions following capsaicin-induced neuronal damage in the nodose ganglion of the adult rat. Frontiers in Neuroscience 5:12
Burgdorf J, Kroes RA, Weiss C, Oh MM, Disterhoft JF, Brudzynski SM, Panksepp J, Moskal J R (2011). Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors. Neuroscience, 192, 515-523. doi: 10.1016/j.neuroscience.2011.05.001
Cearley CN, Blindheim K, Sorg BA, Krueger JM, Churchill L. Acute cocaine increases interleukin-1β mRNA and immunoreactive cells in the cortex and nucleus accumbens. Neurochem Res. 2011 Apr;36(4):686-92. Epub 2011 Mar 12. PubMed PMID: 21399909.
Clinton JM, Davis CJ, Zielinski MR, Jewett K, Krueger JM (2011). Biochemical regulation of sleep and sleep biomarkers. J. Clin. Sleep Med. 7:S38-S42. PMCID: PMC3190410.
Cui RJ, Li X, Appleyard SM. 2011 Mar 2 Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus. J Neurosci. 31(9):3484-92. PMID: 21368060
Davis CJ, Clinton JM, Taishi P, Bohnet SG, Honn, KA, Krueger, JM. (2011) MicroRNA 132 alters sleep and varies with time in brain. J Appl. Physiol. 111:665-672. PMCID: PMC3174793.
Davis CJ, Clinton JM, Jewett K, Zielinski MR, Krueger JM (2011) EEG delta wave power: An independent sleep phenotype or epiphenomena J. Clin. Sleep Med. 7:S16-S18. PMCID: PMC3190419.
Gerashchenko D, Wisor JP, Kilduff TS (2011) Sleep-active cells in the cerebral cortex and their role in slow-wave activity, Sleep Biol Rhythms 9(s1):71-77 PMID :21625335.
Huang YH, Ishikawa M, Lee BR, Nakanishi N, Schluter OM, Dong Y. 2011 Dec 14 Searching for presynaptic NMDA receptors in the nucleus accumbens. J Neurosci. 31(50):18453-63 PMID: 22171047
Jiang P, Striz M, Wisor JP, OHara BF (2011) Behavioral and genetic dissection of a mouse model for advanced sleep phase syndrome, Sleep 34:39-48 PMID:21203370.
Krueger JM, Clinton JM, Winters BD, Zielinski MR, Taishi P, Jewett KA, Davis CJ. (2011) Involvement of cytokines in slow wave sleep. Prog. in Brain Res. 193C:39-47. PMID: 21854954; PMCID: not yet assigned.
Lee BR, Dong Y. 2011 Dec Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyond. Neuropharmacology. 61(7):1060-9. Epub 2011 Jan 11. Review. PMID: 21232547
Li AJ, Wang Q, Ritter S. 2011 Feb Participation of hindbrain AMP-activated protein kinase in glucoprivic feeding. Diabetes. 60(2):436-42. PMID: 21270255
Morairty SR, Wisor JP, Sinko W, Silveira K, Kilduff TS (2011) The wake-promoting effects of hypocretin-1 is attenuated in old rats. Neurobiology of Aging, 32:1514-27 PMID 19781813.
Mu P, Neumann PA, Panksepp J, Schluter OM, Dong Y. (2011). Exposure to cocaine alters dynorphin-mediated regulation of excitatory synaptic transmission in nucleus accumbens neurons. Biological Psychiatry. 69(3):228-35.
Natarajan R, Wright JW, Harding JW. 2011 Sep Nicotine-induced conditioned place preference in adolescent rats. Pharmacol Biochem Behav. 99(3):519-23. Epub 2011 May 11. PMID: 21600911
Normansell L, Panksepp J. (2011). Glutamatergic modulation of separation distress: Profound emotional effects of excitatory amino acids in chicks. Neurosci Biobehav Rev, 35(9), 1890-1901. doi: 10.1016/j.neubiorev.2011.06.004
Peters JH, McDougall SJ, Fawley JA, Andresen MC (2011) TRPV1 marks synaptic segregation of multiple convergent afferents at the rat medial solitary tract nucleus. PLoS One 6: 25015. PMID: 21949835 PMCID: PMC3176783
Ratcliff R, Van Dongen HPA. Diffusion model for one-choice reaction time tasks and the cognitive effects of sleep deprivation. Proceedings of the National Academy of Sciences, 2011; 108(27): 11285-11290.
Siviy SM, Panksepp J. (2011). In search of the neurobiological substrates for social playfulness in mammalian brains. Neurosci Biobehav Rev, 35(9), 1821-1830. doi: 10.1016/j.neubiorev.2011.03.006
Wiater MF, Mukherjee S, Li AJ, Dinh TT, Rooney EM, Simasko SM, Ritter S. Am J Physiol 2011 Nov Circadian integration of sleep-wake and feeding requires NPY receptor-expressing neurons in the mediobasal hypothalamus. Regul Integr Comp Physiol. 301(5):R1569-83. Epub 2011 Aug 31. PMID: 21880863
Sorg BA, Stark G, Sergeeva A, Jansen HT. 2011 Mar 10 Photoperiodic suppression of drug reinstatement. Neuroscience.176:284-95. Epub 2010 Dec 24. PMID: 21185915
Van Dongen HPA, Belenky G, Krueger JM. (2011) A local, bottom-up perspective on sleep deprivation and neurobehavioral performance. Current Topics in Medicinal Chemistry 11:2414-2422. PMCID: PMC3243827.
Van Dongen HPA, Belenky G, Vila BJ. The efficacy of a restart break for recycling with optimal performance depends critically on circadian timing. Sleep, 2011; 34(7): 917-929.
Winters BD, Huang Y, Dong Y, Krueger JM. (2011) Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex. Brain Res 1420:1-7. PMCID: PMC3205322.
Wisor JP, Clegern WC, Schmidt MA (2011) Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss. Sleep 34(10):1335-45 PMID :21966065.
Wisor JP, Clegern WC, Schmidt MA (2011) Cerebral microglia mediate sleep/wake and neuroinflammatory effects of methamphetamine. Brain Behavior and Immunity, 25(4):767-76 PMID:21333736.
Wisor JP, Clegern WC (2011) Quantification of short-term slow wave sleep homeostasis and its disruption by minocycline in the laboratory mouse. Neurosci Lett, 490(3):165-9 PMID:21111032.
Wisor JP et al. (2011) Sleep-active neuronal nitric oxide synthase-positive cells of the cerebral cortex: a local regulator of sleep Curr Topics Med Chem 11(19):2483-9 PMID :21906016.
Wisor JP et al, (2011) Evidence for neuroinflammatory and microglial changes in the cerebral response to sleep loss, Sleep 34(3):261-72 PMID:21358843.
Wright J, Campos CA, Herzog T, Covasa M, Czaja K, Ritter RC, Reduction of food intake by cholecystokinin requires activation of hindbrain NMDA-type glutamate receptors, Am. J Physiol Regul. Integr. Comp Physiol (2011).
Wright J, Campos C, Herzog T, Covasa M, Czaja K, Ritter RC. Am J Physiol Regul Integr Comp Physiol. 2011 Aug Reduction of food intake by cholecystokinin requires activation of hindbrain NMDA-type glutamate receptors.301(2):R448-55. Epub 2011 May 11. PMID: 21562094
Zhao H, Kinch DC, Simasko SM. 2011. Pharmacological investigation of the cellular transduction pathways used by cholecystokinin to activate nodose neurons. Autonomic Neuroscience 164:20-26. PMCID: PMC3167007
Zheng F, Zhou X, Luo Y, Xiao H, Wayman G, Wang H. 2011.Regulation of brain-derived neurotrophic factor exon IV transcription through calcium responsive elements in cortical neurons. PLoS One. 2011;6(12):e28441. Epub 2011 Dec 9 PMID: 22174809
Gallaher ZR, Ryu V, Larios RM, Sprunger LK, Czaja K, Neural proliferation and restoration of neurochemical phenotypes and compromised functions following capsaicin-induced neuronal damage in the nodose ganglion of the adult rat Front Neurosci 5 (2011) 12.

Progress 01/01/10 to 12/31/10

Outputs
OUTPUTS: This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below: PARTICIPANTS: Not relevant to this project. TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Zhang J, Jeffrey BG, Morgans CW, Burke NS, Haley TL, Duvoisin RM, Brown RL. (2010) RGS7 & 11 complexes accelerate the retinal ON-bipolar cell light response. Invest. Ophthalmol. & Vis. Sci. 51(2): 1121-9.
Ruggiero L, Allen CN, Brown RL, Robinson DW. (2010) Mice with early retinal degeneration show differences in neuropeptide expression in the suprachiasmatic nucleus. Behavioral & Brain Functions 6:36.
Brown TE, Lee BR, Ryu V, Herzog T, Czaja K, Dong Y (2010) Reducing hippocampal cell proliferation in the adult rat does not prevent the acquisition of cocaine-induced conditioned place preference. Neurosci Lett 481: 41-46.
Gallaher ZR, Larios RM, Ryu V, Sprunger LK, Czaja K (2010) Recovery of viscerosensory innervation from the dorsal root ganglia of the adult rat following capsaicin-induced injury. J Comp Neurol 518: 3529-3540.
Ryu V, Gallaher Z, Czaja K (2010) Plasticity of nodose ganglion neurons after capsaicin-and vagotomy-induced nerve damage in adult rats. Neuroscience 167: 1227-1238.
Mu P, Moyer JT, Panksepp J, Sorg BA, Schluter OM, Dong, Y#. 2010. Exposure to cocaine dynamically regulates the membrane excitability of nucleus accumbens neurons. J Neurosci 30(10): 3689-3699.
Brown TE, Lee BR, Ryu V, Herzog T, Czaja K, Dong Y#. 2010. Reducing hippocampal cell proliferation in the adult rat does not prevent the acquisition of cocaine-induced conditioned place preference. Neurosci Lett 481 (1): 41-46.
Wright JW, Harding JW. The brain RAS and Alzheimer's disease. Exp Neurol. 2010 Jun;223(2):326-33.
Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum. Paukert M, Huang YH, Tanaka K, Rothstein JD, Bergles DE. J Neurosci. 2010 May 26;30(21):7290-9. PMID: 20505095
Bass CE, Jansen HT, Roberts DC. Free-running rhythms of cocaine self-administration in rats held under constant lighting conditions. Chronobiol Int. 2010, 27(3): 535-48.
Goodman RL, Jansen HT, Billings HJ, Coolen LM, Lehman MN. Neural systems mediating seasonal breedign in the ewe. J Neuroendocrinol. 2010, 22(7): 674-81
Leyva-Grado V, Churchill L, Harding J, Krueger JM. (2010) The olfactory nerve has a role in the body temperature and brain cytokine responses to influenza virus. Brain Beh. Immun. 24:281-288.
Szentirmai E, Kapas, L, Sun Y, Smith RG, Krueger JM. (2010) Restricted feeding-induced sleep, activity and body temperature changes in normal and preproghrelin deficient mice. Am. J. Physiol. 298:R467-R477.
Liao F, Taishi P, Churchill L, Urza JM, Krueger JM. (2010) Localized suppression of cortical growth hormone releasing hormone receptors state-specifically attenuates EEG delta waves. Jour. Neuroscience. 30:4151-4159.
Hallett H, Churchill L, Taishi P, De A, Krueger JM. (2010) Whisker stimulation increases expression of nerve growth factor and interleukin-1 beta immunoreactivity in the rat somatosensory cortex. Brain Res.1333:48-56.
Alcaro A, Panksepp J, Witczak J, Hayes DJ, Northoff G. (2010). Is subcortical-cortical midline activity in depression mediated by glutamate and GABA A cross-species translational approach. Neuroscience & Biobehavioral Reviews. 34(4): 592-605.
Nathaniel TI, Panksepp, J, Huber R. (2010). Effects of a single and repeated morphine treatment on conditioned and unconditioned behavioral sensitization in Crayfish. Behavioural Brain Research, 207, 310-320.
Schoene-Bake JC, Parpaley Y, Weber B, Panksepp J, Hurwitz TA, Coenen VA. (2010). Tractographic analysis of historical lesion surgery for depression. Neuropsychopharmacology, 35(13), 2553-2563. Epub 2010 Aug 25.
Shoudai K, Peters JH, McDougall SJ, Andresen MC (2010) Thermally active TRPV1 tonically drives central spontaneous glutamate release. J Neuroscience 30: 14470-5. PMID: 20980604
Peters JH, McDougall SJ, Fawley JA, Smith SM, and Andresen MC (2010) Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at central neurons. Neuron 65:657-69. PMID: 20223201
Walker JL, Walker BM, Monjaraz Fuentes F, Rector DM. Rat psychomotor vigilance task with fast response times using a conditioned lick behavior. Behav Brain Res 216: 229-237, 2011.
Phillips DJ, Schei JL, Meighan PS, Rector DM. Cortical evoked responses associated with arousal from sleep. Sleep 34(1): 65-72, 2011.
Hight K, Hallett H, Churchill L, De A, Boucher A, Krueger JM. (2010) Time of day differences in the number of cytokine-, neurotrophin- and NeuN-immunoreactive cells in the rat somatosensory or visual cortex. Brain Res.1337:32-40.
Krueger JM, Taishi P, De A, Davis C, Winters BD, Clinton J, Szentirmai E, Zielinski MR. (2010) ATP and the purine type 2 X7 receptor affect sleep. Jour. Appl. Physiol. 109:1318-1327.
Increased hypothalamic signal transducer and activator of transcription 3 phosphorylation after hindbrain leptin injection. Ruiter M, Duffy P, Simasko S, Ritter RC. Endocrinology. 2010 Apr;151(4):1509-19. Epub 2010 Feb 25. PMID: 20185769 [PubMed - indexed for MEDLINE]
Emanuel AJ, Ritter S (2010). Hindbrain catecholamine neurons modulate the growth hormone but not the feeding response to ghrelin. Endocrinology 151: 3237-3246, 2010.
Hudson BD, Emanuel AJ, Wiater MF, Ritter S (2010). The lipoprivic control of feeding is governed by fat metabolism, not by leptin or adipose depletion. Endocrinology 151: 2087-2096, 2010.
Wu X, Wiater MF, Ritter S (2010). NPAS2 deletion impairs responses to restricted feeding but not to metabolic challenges. Physiology & behavior 99: 466-471, 2010.
Li AJ, Wang Q, Ritter S (2010). Participation of Hindbrain AMP-Activated Protein Kinase in Glucoprivic Feeding. Diabetes 60: 436-442, in press.
Role of transient receptor potential channels in cholecystokinin-induced activation of cultured vagal afferent neurons. Zhao H, Simasko SM. Endocrinology. 2010 Nov;151(11):5237-46. Epub 2010 Sep 29.
Mollicone DJ, Van Dongen HPA, Rogers NL, Banks S, Dinges DF. Time of day effects on neurobehavioral performance during chronic sleep restriction. Aviation, Space, and Environmental Medicine, 2010; 81(8): 735-744.
Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in rat. Zhao H, Sprunger LK, Simasko SM. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G212-21. Epub 2009 Dec 3.
Banks S, Van Dongen HPA, Maislin G, Dinges DF. Neurobehavioral dynamics following chronic sleep restriction: Dose-response effects of one night for recovery. Sleep, 2010; 33(8): 1013-1026.
Gander P, Signal L, Van Dongen HPA, Muller D, Van den Berg M. Stable inter-individual differences in slow-wave sleep during nocturnal sleep and naps. Sleep and Biological Rhythms, 2010; 8: 239-244.
Tucker AM, Whitney P, Belenky G, Hinson JM, Van Dongen HPA. Effects of sleep deprivation on dissociated components of executive functioning. Sleep, 2010; 33(1): 47-57.
Impey S, Davare M, Lesiak A, Fortin D, Ando H, Varlamova O, Obrietan K, Soderling TR, Goodman RH, Wayman GA, (2010). An activity-induced microRNA controls dendritic spine formation by regulating Rac1-Pak signaling. Molecular and Cellular Neuroscience (43) 146-156.
Svotloma T, Lin WH, Webb DJ, Yasuda R, Wayman GA, Van Aelst L, Soderlng SH, (2010) Regulation of the postsynaptic cytoskeleton: roles in development, plasticity and disorders. J. Neuroscicence (30) 14937-42
Hansen KF, Sakamoto K, Wayman GA, Impey S, Obrietan, (2010) Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory PLOS One (5) 1-7
Thompson CL, Wisor JP, Lee C, et al. Molecular and anatomical signatures of sleep deprivation in the mouse brain. Front Neurosci 2010;doi: 10.3389/fnins.2010.00165.

Progress 01/01/09 to 12/31/09

Outputs
OUTPUTS: This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below: PARTICIPANTS: Not relevant to this project. TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Fuerst PG, Bruce F, Tian M, Wei W, Elstrott J, Feller MB, Erskine L, Singer JH, Burgess RW. (2009). DSCAM and DSCAML1 Function in Self-Avoidance in Multiple Cell Types in the Developing Mouse Retina. Neuron 64, 484-497.
Wright JW, Harding JW. (2009). The brain angiotensin IV AT4 receptor system as a new target for the treatment of Alzheimer's disease. Drug Development Research 70, 472-480.
Wright JW, Meighan PC, Davis CJ, Olson ML, Weidiger RS, Harding JW. (2009) Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3. Behavioral Brain Research. 203, 27-34.
Wilson WL, Munn C, Ross RC, Harding JW, Wright JW. (2009) The role of the AT4 and cholinergic systems in the nucleus basalis magnocellularis (NBM): effects on spatial memory. Brain Research. 1272, 25-31
Wright JW, Harding JW. The brain RAS and Alzheimer's disease. Experimental Neurology (2009; Epub ahead of print)
Sergeeva A, Jansen HT. Neuroanatomical plasticity in the GnRH system of the ewe: Seasonal variation in glutamatergic and GABAergic afferents. J. Comp. Neurol. 515:615-628, 2009.
Appleyard SM. (2009) Lighting up neuronal pathways: the development of a novel transgenic rat that identifies Fos-activated neurons using a red fluorescent protein. Endocrinology 150(2): 5199-201.
Ishikawa M, Moyer J, Wolf JA, Quock RM, Davis NM, Schluter OM, Dong Y. 2009. Homeostatic Synapse-driven Membrane Plasticity in Nucleus Accumbens Neurons. Journal of Neuroscience 29(18): 5820-31.
Mu P, Fuchs T, Saal DB, Sorg B, Dong Y, Panksepp J. 2009. Repeated Cocaine Exposure Induces Sensitization of Ultrasonic Vocalization in Rats. Neuroscience Letter 453(1): 31-5.
Daftary SS, Pansepp J, Dong Y, Saal, DB. 2009. Glucocorticoid signaling mediates stress-induced synaptic adapatation in midbrain dopamine neurons. Neuroscience Letters 452(3): 273-6.
Huang YH, Lin Y, Mu P, Lee BR, Brown TE, Wayman GA, Marie H, Liu W, Yan Z, Sorg BA, Schluter OM, Zukin RS, Dong Y. 2009. In vivo Cocaine Experience Generates Silent Synapses. Neuron. 63:40-47.
Fuerst PG, Burgess RW. (2009). Adhesion molecules in establishing retinal circuitry. Curr Opin Neurobiol 19, 389-394.
Ruggiero L, Allen CN, Brown RL, Robinson DW. (2009) The development of melanopsin-containing retinal ganglion cells in mice with early retinal degeneration. European J. Neurosci. 29: 359-367.
Morgans CW, Zhang J, Jeffrey BG, Nelson SM, Burke NS, Duvoisin RM, Brown RL. (2009) TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Proc. Natl. Acad. Sci. USA. 106 (45) 19174-19178
Peterfi Z, Makara GB, Obal Jr F, Krueger JM (2009) The anterolateral projections of the medial basal hypothalamus affect sleep. Am. J. Physiol. 296:R1228-R1238.
Rector DM, Schei JL, Van Dongen HPA, Belenky G, Krueger JM. (2009) Physiological markers of localized sleep. Europ. J. Neurosci. 29:1771-1778.
Leyva-Grado V, Churchill L, Wu M, Williams TJ, Taishi P, Majde JA, Krueger JM. (2009) Influenza virus- and cytokine-immunoreactive cells in the murine olfactory pathway and hypothalamus before and after illness onset. J. Neuroimmunol. 211:73-83.
May U, Schiffelholz T, Baier PC, Krueger JM, Rose-John S, Scheller J. (2009) IL-6trans signalling increases rapid eye-movement sleep in rats. European. J. Pharmacology 613:141-145.
Szentirmai E, Kapas L, Sun Y, Smith RG, Krueger JM. (2009) The preproghrelin gene is required for normal integration of thermoregulation and sleep in mice. Proc. Natl. Acad. Sci. USA 106:14069-14074.
Daftary SS, Panksepp J, Dong Y, Saal DB. (2009). Stress-induced, glucocorticoid-dependent strengthening of glutamatergic synaptic transmission in midbrain dopamine neurons. Neuroscience Letters, 452, 273-276.
Watt DF, Panksepp, J. (2009). Depression: an evolutionarily conserved mechanism to terminate separation-distress A review of aminergic, peptidergic, and neural network perspectives. Neuropsychoanalysis, 11, 5-104.
Northoff G, Schneider F, Rotte M, Matthiae C, Tempelmann C, Wiebking C, Bermpohl F, Heinzel A, Danos P, Heinze HJ, Bogerts B, Walter M, Panksepp J. (2009). Differential parametric modulation of self-relatedness and emotions in different brain regions. Human Brain Mapping, 30, 369-382.
Panksepp J, Northoff G. (2009). The trans-species core self: The emergence of active cultural and neuro-ecological agents through self related processing within subcortical-cortical midline networks. Consciousness & Cognition, 18, 193-215.
Deak T, Arakawa H, Bekkedal MY, Panksepp J. (2009). Validation of a novel social investigation task that may dissociate social motivation from exploratory activity. Behavioral Brain Research 199(2): 326-33.
Vandekerckhove M, Panksepp, J. (2009). The flow of anoetic to noetic and autonoetic consciousness: A vision of unknowing (anoetic) and knowing (noetic) consciousness in the remembrance of things past and imagined futures. Consciousness & Cognition, 18, 1018-28.
Topchiy IA, Wood RM, Peterson B, Navas JA, Rojas MJ, Rector DM. Conditioned lick behavior and evoked responses using whisker twitches in head restrained rats. Behavioural Brain Research 197(1):16-23, 2009.
Rector DM, Schei JL, Rojas MJ. Mechanisms underlying state dependent surface evoked response patterns. Neuroscience 159: 115-126, 2009.
Wininger FA, Schei JL, Rector DM. Complete optical neurophysiology: toward optical stimulation and recording of neural tissue. Applied Optics 48(10): D218-24, 2009.
Schei JL, Foust AJ, Rojas MJ, Navas JA, Rector DM. State dependent auditory evoked hemodynamic responses recorded optically with indwelling photodiodes. Applied Optics 48(10): D121-9, 2009.
Wang J, Sengupta P, Guo Y, Golebiewska U, Scarlata S. (2009) Evidence for a second, high affinity Gbetagamma binding site on Galphai1(GDP) subunits. J Biol Chem. 284: 16906.
Sengupta P, Bosis E, Nachliel E, Gutman M, Smith SO, Mihalyne G, Zaitseva I, McLaughlin S. (2009) EGFR juxtamembrane domain, membranes, and calmodulin: kinetics of their interaction. Biophys J 96: 4887.
Simasko SM, Mukherjee S. Novel analysis of sleep patterns in rats separates periods of vigilance cycling from long-duration wake events. Behav. Brain Res. 196(2): 228-36, 2009.
Brown TE, Wilson AR, Cocking DL, Sorg BA. (2009) Inhibition of matrix metalloproteinase activity disrupts reconsolidation but not consolidation of a fear memory. Neurobiol Learn Mem 91:66-72. PMCID: PMC2719776
Wright JW, Meighan PC, Brown TE, Wiediger RV, Sorg BA, Harding JW. (2009) Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3. Behav Brain Res 203:27-34.
Zhao H, Sprunger LK, Simasko SM. 2010 (E pub Dec 2 2009). Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in rat. Am. J. Physiol. - Gastroent. & Liver Physiol. 298(2):G212-21.
Ratcliff R, Van Dongen HPA. Sleep deprivation affects multiple distinct cognitive processes. Psychonomic Bulletin & Review 2009; 16(4): 742-751.
Van Dongen HPA, Belenky G. Individual differences in vulnerability to sleep loss in the work environment. Industrial Health 2009; 47(5): 518-526.
Yang S, Van Dongen HPA, Wang K, Berrettini W, Buan M. Assessment of circadian function in fibroblasts of patients with bipolar disorder. Molecular Psychiatry 2009; 14: 143-155.
Kim WD, Gonsiorek EA, Barnhart C, Davare MA, Engebose AJ, Lauridsen H, Bruun D, Lesiak A, Wayman GA, Bucelli R, Higgins D, Lein PJ, (2009) epublished (2008) Statins decrease dendritic arborization in rat sympathetic -neurons by blocking RhoA activation. J Neurochem 108(4) 1057-71
Davare MA, Fortin D, Saneyoshi T, Nygaard S, Kaech S, Banker G, Soderling TR, Wayman GA, (2009) Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase I to promote axon formation in hippocampal neurons. J. Neuroscience 29(31) 9794-808.

Progress 01/01/08 to 12/31/08

Outputs
OUTPUTS: This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below: PARTICIPANTS: Not relevant to this project. TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Vasavada AN, Lasher RA, Meyer TE, Lin DC 2008. Defining and evaluating wrapping surfaces for MRI-derived spinal muscle paths. J Biomech 41: 1450-57.
Cloutier S, Newberry RC 2008. Use of conditioning technique to reduce stress associated with repeated intra-peritoneal injections in laboratory rats. Applied Animal Behaviour Science 112 (1-2): 158-173.
Newberry RC, Swanson JC 2008. Implications of breaking mother-young social bonds. Applied Animal Behaviour Science 110(1-2): 3-23.
Dennis RL, Newberry RC, Cheng HW, Estevez I 2008. Appearance matters: artificial marking alters aggression and stress. Poult Sci 87: 1939-46.
Schei JL MD, McCluskey AJ, Foust XC, Yao, Rector DM 2008. Action potential propagation imaged with high temporal resolution near-infrared video microscopy and polarized light. NeuroImage. 40(3):1034-1043.
Foust AJ, Schei JL, Rojas MJ, Rector DM 2008. In-vitro and in-vivo noise analysis for Optical Neural Recording. Journal of Biomedical Optics. 13(4): 044038.
Yeager JD, Phillips DJ, Rector DM, Bahr DF 2008. Characterization of flexible ECoG electrode arrays for chronic recording in awake rats. Journal of Neuroscience Methods. 173(2): 279-285.
Li AJ, Dinh TT, Ritter S 2008. Hyperphagia and obesity produced by arcuate injection of NPY-saporin do not require upregulation of lateral hypothalamic orexigenic peptide genes. Peptides. 29(10): p. 1732-9.
Mukherjee S, Kazerooni M, Simasko, SM 2008. Dose-response study of chronic alcohol induced changes in sleep patterns in rats. Brain Res. 1208: 120-7.
Brown TE, Lee BR, Sorg BA 2008. The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. Learn Mem 15: 857-65.
Bjorklund NL, Sorg BA, Schenk JO. Neuronal dopamine transporter activity, density and methamphetamine inhibition are differentially altered in the nucleus accumbens and striatum with no changes in glycosylation in rats behaviorally sensitized to methamphetamine. Synapse 62: 736-45, 2008 (PMID 18651643)
Rojas MJ, Navas JA, Greene SA, Rector DM 2008. Discrimination of auditory stimuli during isoflurane anesthesia. Comparative Medicine. 53(5): 454-457.
Craft RM, Ulibarri C, Leiti MD, Sumner JE 2008. Dose- and time-dependent estradiol modulation of morphine antinociception in adult female rats. Eur J Pain 12: 472-79 (PMID 17869144)
Wayman GA, Lee YS, Tokumitsu H, Silvia A, Soderling TR. Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron 59: 914-31, 2008 (PMID 18817731)
Bailey TW, Appleyard SM, Jin YH, Andresen MC 2008. Organization and properties of GABAergic neurons in solitary tract nucleus (NTS). J Neurophysiol 99 (4): 1712-1722.
Walker MT, Brown RL, Cronin TW, Robinson PR 2008. Photochemistry of retinal chromophore in mouse melanopsin. Proc. Natl Acad. Sci. USA 105 (26): 8861-8865.
Suzuki N, Yamazaki Y, Brown RL, Fujimoto Z, Morita T, Mizuno H 2008. Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain. Acta Crystallogr. D. Biol. Crystallogr. 64 (10): 1034-1042.
Churchill L, Rector D, Yasuda K, Fix C, Rojas M, Yasuda T, Krueger JM 2008. Tumor necrosis factor alpha: activity dependent expression and promotion of cortical column sleep in rats. Neuroscience 156: 71-80.
Czaja K, Burns GA, Ritter RC 2008. Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats. Neuroscience 154:621-630
Huang YH, Lin Y, Brown T, Han MH, Saal D, Neve RL, Zukin RS, Sorg, BA, Nestler EJ, Malenka RC, Dong Y 2008. CREB modulates the upstate of nucleus accumbens neurons: A critical role of synaptic NMDA receptors. Journal of Biological Chemistry, 283(5): 2751-60.
Tyszkiewicz JP, Fong TM, Dong Y 2008. GABA(B) receptors are required for galanin modulation of membrane properties of neurons in the arcuate nucleus of rats. Brain Research. 1191: 63-8.
Lee BC, Mu P, Saal DB, Ulibarri C, Dong Y 2008. Homeostatic Recovery of Downstate-Upstate Cycling in Nucleus Accumbens Neurons. Neuroscience Letters. 434(3): 282-8.
Olson, ML, Meighan PC, Brown TE, Asav AL, Harding JW, Wright JW 2008. Hippocampal MMP-3 elevation is associated with passive avoidance conditioning. Regulatory Peptides, 146:19-25.
Wright JW, Yamamoto BJ, Harding JW 2008. Angiotensin receptor subtype mediated physiologies and behaviors: New discoveries and clinical targets. Progress in Neurobiology, 84: 157-181.
Holtfreterk KL, Murphy ES, Harding JW, Wright JW 2008. Effects of suprachiasmatic nucleus lesions on habituation of the head-shake response. Neuroscience Letters, 439:203-207.
Brown TE, Forquer M, Harding JW, Wright JW, Sorg BA 2008. Increase in matrix metalloproteinase-9 levels in the rate medial prefrontal cortex after drug reinstatement of conditioned place preference. Synapse, 62:886-889.
Wright JW, Harding JW 2008. The angiotensin AT4 recepto subtype as a target for the treatment of memory dysfunction associated with Alzheimers disease. Journel of the Renin-Angiotensin-Aldosterone Systems, 9:226-237.
Kapas L, Bohnet S, Traynor T, Majde JA, Szentirmai E, Magrath P, Taishi P, Krueger JM 2008. Spontaneous and influenza virus-induced sleep are altered in TNFa double receptor deficient mice. J Appl Physiol 105:1187-1198
Sleipness EP, Jansen HT, Schenk JO, Sorg BA 2008. Time-of-day differences in dopamine clearance in the rat medial prefrontal cortex and nucleus accumbens. Synapse. (12):877-85.
Krueger JM 2008. The role of cytokines in sleep regulation. Current Pharm Design 14:3408-3416.
Krueger JM, Rector DM, Roy S, Van Dongen HPA, Belenky G, Panksepp J 2008. Sleep as a fundamental property of neuronal assemblies. Nature Reviews Neuroscience 9:910-919.
Lin DC, Bucher BP, Davis HP, Sprunger LK 2008 Mar 30. A low-cost telemetry system suitable for measuring mouse biopotentials. Med Eng Phys. (2):199-205. (PMID: 17403611)
Luikart BW, Zhang W, Wayman GA, Kwon CH, Westbrook GL, Parada LF 2008. Neurotropin-dependent dendritic filopodial motility: a convergence of PI3K signaling. J Neurosci 28:7006-12 (PMID 18596174).
Wayman GA, Davare M, Ando H, Fortin D, Varlamova O, Cheng HY, Marks D, Obrietan K, Soderling TR, Goodman RH, Impey S 2008. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci 26: 9093-8 (PMID 18577589).
Mollicone DJ, Van Dongen HPA, Rogers NL, Dinges DF 2008. Response surface mapping of neurobehavioral performance: Testing the feasibility of split sleep schedules for space operations. Acta Astronautica; 63: 833-840.
Saneyoshi T, Wayman GA, Fortin D, Davare M, Hoshi N, Nozaki N, Natsume T, Soderling TR 2008. Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron Jan 10; 57(1): 94-107.
Yang D, Kim KH, Phimister A, Ward T, Stackman RW, Mervis R, Wisniewski AB, Klein S, Kodavanti P, Anderson K, Wayman GA, Pessah IN, Lein P 2008. Developmental Exposure to Polychlorinated Biphenyls (PCBs) Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats Environmental Health Perspectives Mar 22:117(3):426-35.
Kim WY, Gonsiorek EA, Barnhart C, Davare MA, Engebose AJ, Lauridsen H, Bruun D, Lesiak A, Wayman GA, Bucelli R, Higgins D, Lein PJ 2009. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. J Neurochem. Feb; 108(4):1057-71 (Epub 2008)
Oonk M, Tucker AM, Belenky G, Van Dongen HPA 2008. Excessive sleepiness: determinants, outcomes, and context. International Journal of Sleep and Wakefulness; 1(4): 141-147.
Wisor JP et al, 2008 Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains. Journal of Neuroscience 28:7193-7201.
Gerashchenko D, Wisor JP et al, 2008 Identification of a population of sleep-active cerebral cortex neurons. Proc Natl Acad Sci, 105:10227-10232.
Xie X, Wisor JP et al 2008. Opposing modulation of stress-induced analgesia by hypocretin/orexin and nociceptin/orphanin FQ. Journal of Clinical Investigation, 118(7):2471-81.
Terao A, Huang ZL, Wisor JP et al, 2008 Gene expression in the rat brain during prostaglandin D (2) and adenosinergically-induced sleep. J Neurochem 105:1480-1498.

Progress 01/01/07 to 12/31/07

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Burgdorf J, Wood PL, Kroes RA, Moskal JR, Panksepp J. (2007). Neurobiology of 50-kHz ultrasonic vocalizations in rats: Electrode mapping, lesion, and pharmacology studies.Behavioral Brain Research. 182(2): 274-83.
McCluskey MD, Sable JJ, Foust AJ, Gratton G, Rector DM. Recording invertebrate nerve activation with modulated light changes. Applied Optics. 46(10): 1866-1871 (2007).
Foust AJ, Rector DM. Optically teasing apart neural swelling and depolarization. Neuroscience. 145(3): 887-899 (2007).
Benison AM, Rector DM, Barth DS. Hemispheric mapping of secondary somatosensory cortex in the rat. Journal of Neurophysiology 97: 200-207. (2007)
Peters JH, Simasko SM, Ritter RC. 2007. Leptin analog antagonizes leptin effects on food intake and body weight but mimics leptin-induced vagal afferent activation. Endocrinology 148(6): 2878-85.
Wiater MF, Hudson BD, Virgin Y, Ritter S. (2007). Protein appetite is increased after central leptin-induced fat depletion. Am J Physiol Regul Integr Comp Physiol. 2007 Oct;293(4):R1468-73. Epub 2007 Jun 27.
Taylor K, Lester E, Hudson B, Ritter S. Hypothalamic and hindbrain NPY, AGRP and NE increase consummatory feeding responses. Physiol Behav. 2007 Apr 23;90(5):744-50. Epub 2007 Jan 4.
Taishi P, Churchill L, Wang M, Kay D, Davis CJ, Guan X, De A, Yasuda T, Liao F, Krueger JM TNF-alpha siRNA reduces brain TNF and EEG delta wave activity in rats. (2007) Brain Res 1156: 125-132.
Majde JA, Bohnet SG, Ellis GA, Churchill L, Leyva-Grado V, Wu M, Szentirmai E, Rehman A, Krueger JM Detection of mouse-adapted human influenza viruses in the olfactory bulbs of mice within hours after intranasal infection. (2007) J of NeuroVirology 13:399-409.
Szentirmai E, Yasuda T, Taishi P, Wang M, Churchill L, Bohnet S, McGrath P, Kacsoh B, Jimenez L, Krueger JM Growth hormone releasing hormone: Cerebral cortical sleep-related EEG actions and expression. (2007) Am J Physiol Regul Integr Comp Physiol (293: R922-R930).
Gifford AK, Cloutier S, Ruth C, Newberry. RC 2007. Objects as enrichment: Effects of object exposure time and delay interval on object recognition memory of the domestic pig. Applied Animal Behaviour Science, Volume 107, Pages 206-217
Wright JW, Yamamoto BJ, Harding JW 2007. Angiotensin receptor subtype mediated physiologies and behaviors: New discoveries and clinical targets. Prog Neurobiol. 2007 Nov 19. PMID: 18160199.
Olson ML, Meighan PC, Brown TE, Asay AL, Benoist CC, Harding JW, Wright JW. Hippocampal MMP-3 elevation is associated with passive avoidance conditioning. Regul Pept. 2008 Feb 7;146(1-3):19-25. Epub 2007 Jul 19.
Meighan PC, Meighan SE, Davis CJ, Wright JW, Harding JW. Effects of matrix metalloproteinase inhibition on short- and long-term plasticity of schaffer collateral/CA1 synapses. J Neurochem. 2007 Sep;102(6):2085-96. Epub 2007 Jun 22.
Wright JW, Brown TE, Harding JW. Inhibition of hippocampal matrix metalloproteinase-3 and -9 disrupts spatial memory. Neural Plast. 2007;2007:73813.
Brown TE, Forquer MR, Cocking DL, Jansen HT, Harding JW, Sorg BA. Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preference. Learn Mem. 2007 Mar 9;14(3):214-23. Print 2007.
Sleipness EP, Sorg BA, Jansen HT. Contribution of the suprachiasmatic nucleus to day:night variation in cocaine-seeking behavior. Physiol Behav. 2007 Aug 15;91(5):523-30. Epub 2007 Mar 3.
Brown TE, Forquer MR, Cocking DL, Jansen HT, Harding JW, Sorg BA. Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preference. Learn Mem. 2007 Mar 9;14(3):214-23. Print 2007.
Jansen HT, Kirby JD, Cooke PS, Arambepola N, Iwamoto GA. Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. Physiol Behav. 2007 Apr 23;90(5):771-81. Epub 2007 Jan 13.
Sleipness EP, Sorg BA, Jansen HT. Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: dependence on the suprachiasmatic nucleus. Brain Res. 2007 Jan 19;1129(1):34-42.
Traynor T, Majde JA, Bohnet S, Krueger JM. (2007) Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus. Brain Behav Immunity 21: 311-322.
Davis CJ, Bohnet SG, Meyerson JM, Krueger JM. (2007) Sleep loss changes microRNA levels in the brain: A possible mechanism for state-dependent translational regulation. Neurosci Lett 422:68-73.
Szentirmai E, Kapas L, Krueger JM. (2007) Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am J Physiol 292: R575-R585.
Cambras T, Weller JR, Angles-Pujoras M, Lee M, Christopher H, Oiez-Noguera A, Krueger JM, de la Iglesia H. (2007) Desynchronization of core body temperature and sleep stages is associated with uncoupling of oscillators within the master circadian clock. Proc Natl Acad Sci. 104: 7634-7639.
Szentirmai E, Kapuas L, Sun Y, Smith RG, Krueger JM. (2007) Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice. Am J Physiol. 293:R510-R517.
Newberry RC, Keeling LJ, Estevez I, Bilcik B. Behaviour when young as a predictor of severe feather pecking in adult laying hens: The redirected foraging hypothesis revisited, Applied Animal Behaviour ScienceVolume 107, Issues 3-4, November 2007, Pages 262-274.
Nocjar C, Panksepp J (2007). Prior morphine experience induces long-term increases in social interest and in appetitive behavior for natural reward. Behavioral Brain Research. 181(2): 191-9.
Kroes RA, Burgdorf J, Otto NJ, Panksepp J, Moskal JR (2007). Social defeat, a paradigm of depression in rats that elicits 22-kHz vocalizations, preferentially activates the cholinergic signaling pathway in the periaqueductal gray. Behavioral Brain Research. 182(2) 290-300.
Panksepp J, Burgdorf J, Beinfeld MC, Kroes R, Moskal J. (2007). Brain regional neuropeptide changes resulting from social defeat. Behavioral Neuroscience, 121: 1364-1371.
Huang YH, Lin Y, Brown TE, Han MH, Saal DB, Neve RL, Zukin RS, Sorg BA, Nestler EJ, Malenka RC, Dong Y. CREB modulates the functional output of nucleus accumbens neurons: A critical role of NMDA receptors. J Biol Chem. 2007 Nov 30; [Epub ahead of print]
Sun Y, Godfrey DA, Chen K, Sprunger LK, Rubin AM. Comparison of gamma-aminobutyrate receptors in the medial vestibular nucleus of control and Scn8a mutant mice. Brain Res. 2007 Dec;1186:188-93. Epub 2007 Oct 17.
Craft RM, Ulibarri C, Leitl MD, Sumner JE. Dose- and time-dependent estradiol modulation of morphine antinociception in adult female rats. Eur J Pain. 2007 Sep 12; [Epub ahead of print]
Bright SR, Rich ED, Varnum MD. Regulation of human cone cyclic nucleotide-gated channels by endogenous phospholipids and exogenously applied phosphatidylinositol 3,4,5-trisphosphate. Mol Pharmacol. 2007 Jan;71(1):176-83.
Yasuda K, Churchill L, Yasuda T, Blindheim K, Falter M, Krueger JM Unilateral cortical application of Interleukin-1 (IL-1) induces asymmetry in Fos- and IL-1-immunoreactivity in specific brain regions: implications for sleep regulation. (2007). Brain Res. 1131: 44-59.
Andrew SF, Dinh TT, Ritter S. Localized glucoprivation of hindbrain sites elicits corticosterone and glucagon secretion. Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1792-8. Epub 2007 Jan 11.
Appleyard, SM, Marks D, Kobayashi K, Okano H, Low MJ, Andresen MC Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus. (2007) Journal of Neuroscience 27 (48): 13292-302.
Koch HP, Brown RL, Larsson HP (2007) The glutamate-activated anion conductance in EAATs is gated independently by the individual subunits. J. Neurosci. 27(11): 2943-2947.
Morgans CW, Liu W, Wensel TG, Bearnot B, Perez-Leon JA, Brown RL, Duvoisin RM (2007) Gb5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells. European J. Neurosci. 26: 2899-2905.

Progress 01/01/06 to 12/31/06

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Brady JD, Rich ED, Martens JR, Karpen JW, Varnum MD, Brown RL. Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15635-40.
Davis CJ, Meighan PC, Taishi P, Krueger JM, Harding JW, Wright JW. 2006. REM sleep deprivation attenuates actin-binding protein cortactin: A link between sleep and hippocampal plasticity. Neuroscience Letters, 400: 191-196.
Meighan SE, Meighan PC, Choudhury P, Davis CJ, Olson ML, Zornes PA, Wright JW, Harding JW. 2006. Effects of extracellular matrix-degrading matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity. Journal of Neurochemistry, 96: 1227-1241.
Traynor TR, Majde JA, Bohnet SG, Krueger JM. 2006. Sleep and body temperature responses in an acute viral infection model are altered in interferon type I receptor-deficient mice. Brain Beh. Immunity. 20: 290-299.
Kushikata T, Fang J, Krueger JM. 2006. Platelet activating factor and its metabolite promote sleep in rabbits. Neurosci. Lett. 394: 233-238.
Peterfi Z, Obal F Jr, Taishi P, Gardi J, Kacsoh B, Unterman T, Krueger J.M. 2006. Sleep in spontaneous dwarf rats. Brain Res. 1108: 133-146.
Szentirmai E, Krueger JM. 2006. Obestatin alters sleep in rats. Neurosci. Lett. 404: 222-226.
Northoff G, Heinzel A, de Greck M, Bermpohl F, Dobrowolny H, Panksepp J. Self-referential processing in our brain--a meta-analysis of imaging studies on the self. Neuroimage. 2006 May 15;31(1):440-57.
Deak T, Panksepp J. Play behavior in rats pretreated with scopolamine: increased play solicitation by the non-injected partner. Physiol Behav. 2006 Jan 30;87(1):120-5.
Burgdorf J, Panksepp J, Beinfeld MC, Kroes RA, Moskal JR. Regional brain cholecystokinin changes as a function of rough-and-tumble play behavior in adolescent rats. Peptides. 2006 Jan;27(1):172-7.
Burgdorf J, Panksepp J. The neurobiology of positive emotions. Neurosci Biobehav Rev. 2006;30(2):173-87.
Kroes RA, Panksepp J., Burgdorf J., Otto NJ, Moskal JR. (2006). Social dominance-submission gene expression patterns in rat neocortex. Neuroscience, 137, 37-49.
Hung CY, Covasa M, Ritter RC, Burns GA. Hindbrain administration of NMDA receptor antagonist AP-5 increases food intake in the rat. Am J Physiol Regul Integr Comp Physiol 290: R642-651, 2006.
Peters JH, Ritter RC, Simasko SM. Leptin and CCK modulate complementary background conductances to depolarize cultured nodose neurons. Am J Physiol Cell Physiol 290: C427-432, 2006.
Ritter S, Dinh TT, Li AJ. Hindbrain catecholamine neurons control multiple glucoregulatory responses. Physiol Behav. 2006 Nov 30;89(4):490-500.
Dinh TT, Flynn FW, Ritter S. Hypotensive hypovolemia and hypoglycemia activate different hindbrain catecholamine neurons with projections to the hypothalamus. Am J Physiol Regul Integr Comp Physiol. 2006 Oct;291(4):R870-9.
Bartoo AC, Sprunger LK, Schneider DA. 2006. Expression of the sodium channel Nav1.2 in chemically identified myenteric neurons in the guinea pig. Cell Tiss. Res. 324(1): 25-32. (Epub: December 22, 2005)
Bartoo AC, Sprunger LK, Schneider DA. 2006. Expression of sodium channel Nav1.6 in cholinergic myenteric neurons of guinea pig proximal colon. Cell Tiss. Res. 325(2):203-209. Epub: March 23, 2006.
Czaja K, Ritter RC, Burns GA. Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes. Brain Res. 2006 Nov 13;1119(1):86-93.
Czaja K, Ritter RC, Burns GA. N-methyl-D-aspartate receptor subunit phenotypes of vagal afferent neurons in nodose ganglia of the rat. J Comp Neurol. 2006 Jun 20;496(6):877-85.
Churchill L., Taishi P., Wang M, Brandt J, Clearley C, Rehman A, Krueger JM 2006. Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1 or tumor necrosis factor . Brain Res. 1120:64-73
Dong Y, Tyszkiewicz JP, Fong TM. 2006. Galanin and GALP differentially modulate the neuronal activity in rat hypothalamic arcuate nucleus neurons. J. Neurophysiol. 95(5):3228-34.
Davis CJ, Kramar EA, De A, Meighan PC, Simasko, SM, Wright JW, Harding JW. 2006. AT4 receptor activation increases intacellular calcium influx and induces a non-N-methyl-D-aspartate dependent form of long-term potentiation. Neuroscience, 137: 1369-1379.

Progress 01/01/05 to 12/31/05

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Gillespie, B.R., G.A. Burns, and R.C. Ritter. 2005. NMDA channels control meal size via central vagal afferent terminals. Physiol. Regul. Integr. Comp. Physiol. (5): R5204-R5111.
Churchill, L., Yasuda, K., Yasuda, T., Blindheim, K., Falter, M., Garcia-Garcia, F. and Krueger, J.M. 2005. Unilateral cortical application of tumor necrosis factor alpha induces asymmetry in Fos- and Interleukin-1beta-immunoreactive cells within the corticothalamic projection. Brain Res. 1055:15-24.
Murphy, E.S., Harding, J.W., Muhunthan, K., Holtfreter, K.L. and Wright, J.W. 2005. Role of mitogen-activated protein kinases during recovery from head-shake response habituation in rats. Brain Research 1050: 170-179.
Sleipness, E.P., Sorg, B.A. and Jansen, H.T. 2005. Time of day alters long-term sensitization to cocaine in rats. Brain Res. 1065:132-137.
Yasuda, T., Yoshida, H., Garcia-Garcia, F., Kay, D. and Krueger, J.M. 2005. Interleukin-1beta has a role in cerebral cortical state dependent electroencephalographic slow-wave activity. Sleep 28: 177-184.
Tang, C., Sula, M.J., Bohnet, S., Rehman, A., Taishi, P. and Krueger, J.M. 2005. Interleukin-1beta induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP. Mol. Brain Res. 137: 213-222.
Churchill, L., Yasuda, K., Yasuda, T., Blindheim, K., Falter, M., Garcia-Garcia, F. and Krueger, J.M. 2005. Cortical application of tumor necrosis factor alpha induces asymmetry in Fos- and interleukin-1beta immunoreactive cells within the corticothalamic projection. Brain Res. 1055: 15-24.
Yasuda, T., Yasuda, K., Brown, R. and Krueger, J.M. 2005. State-dependent effects of the light/dark cycle on the somatosensory and the visual cortex EEG in rats. Am. J. Physiol. 289: R1083-R1089.
Rector, D.M., K.M. Carter, P.L. Volegov, and J.S. George. 2005. Spatio-temporal mapping of rat whisker barrels with fast scattered light signals. NeuroImage 26(2): 619-627.
Yao, X.C., Foust, A.J., Rector, D.M., Barrowes, B.and George, J.S. 2005. Cross-polarized reflected light measurement of fast optical responses associated with neural activation. Biophys. J. 88(6): 4170-4177.
Covasa, M. and Ritter, R.C.. 2005. Reduced CCK-induced Fos expression in the hindbrain, nodose ganglia, and enteric neurons of rats lacking CCK-1 receptors. Brain Res. 1051: 155-163.
Gulley, S., Covasa, M., Ritter, R.C and Sayegh, A.I. 2005. Cholecystokinin-1 receptors mediate the increase in Fos-like immunoreactivity in the rat myenteric plexus following intestinal oleate infusion. Physiol. Behav. 86: 128-135.
Li, A.J. and Ritter, S. 2005. Functional expression of NPY receptors in human neuroblastoma cells. Regulatory Peptides 129, 119-124.
Bartoo, A.C., Sprunger, L.K. and Schneider, D.A. 2005. Expression and distribution of TTX-sensitive sodium channel alpha subunits in the enteric nervous system. J. Comp. Neurol. 406: 117-131.
Liu, C., and Varnum, M.D. 2005. Functional consequences of cone dystrophy-associated mutations in the human cone photoreceptor cyclic nucleotide-gated channel CNGA3 subunit. Am. J. Physiol.-Cell Physiol. 289(1):C187-98.
Bright, S.R., Brown, T.E. and Varnum, M.D. 2005. Disease-associated mutations in CNGB3 produce gain of function alterations in cone cyclic nucleotide-gated channels. Molecular Vision 11:1141-50.

Progress 01/01/04 to 12/31/04

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Wright JW, Murphy ES, Elijah IE, Holtfreter KL, Davis CJ, Olson ML,Muhunthan K, Harding JW. 2004. Influence of hippocampectomy on habituation, exploratory behavior, and spatial memory in rats. Brain Res. 1023(1)1-14.
Albiston AL, Pederson ES, Burns P, Purcell B, Wright JW, Harding JW, Mendelsohn FA, Weisinger RS, Chai SY. 2004. Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigms. Behav Brain Res.; 154(1):239-43.
Taishi, P, De A, Alt J, Gardi J, Obal F Jr, Krueger JM. 2004. Interleukin-1b stimulates GHRH receptor mRNA expression in the rat hypothalamus in vitro and in vivo. J. Neuroendocrinol. 16:113-118.
Garcia-Garcia F, Yoshida H, Krueger JM. 2004. Interleukin-8 promotes sleep in rabbits and rats. J. Sleep Res. 13: 55-61.
Chen L, Taishi P, Majde JA, Peterfi Z, Obal F Jr, Krueger JM. 2004. The role of nitric oxide synthases in the sleep response to tumor necrosis factor. Brain Behav. Immun. 18: 390-398.
Wright JW, Alt JA, Turner GD, Krueger JM. 2004. Differences in spatial learning comparing transgenic p75 knockout New Zealand Black, C57BL/6 and Swiss Webster mice. Behav. Brain Res. 153: 453-458.
Yoshida H., Peterfi Z, Garcia-Garcia F, Kirkpatrick R, Yasuda T, Krueger JM. 2004. Asymmetrics in slow wave sleep EEG induced by local application of TNF. Brain Res. 1009: 129-136.
Chen L, Taishi P, Duricka D, Krueger JM. 2004. Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity. Mol. Brain Res. 129: 179-184.
Bodosi B, Gardi J, Hajdu I, Szentirmai E, Obal F Jr, Krueger JM. 2004. Rhythms of ghrelin, leptin and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation. Am. J. Physiol. 287: R1071-R1079.
Bohnet SG, Traynor TR, Majde JA, Kacsoh B, Krueger JM. 2004. Mice deficient in the interferon type I receptor have reduced REM sleep and altered hypothalamic orexin, prolactin and 2', 5'-oligoodenylate synthatase expression. Brain Res. 1027: 117-125.
Carter KM, George JS, Rector DM. 2004. Simultaneous birefringence and scattered light measurements reveal anatomical features in isolated crustacean nerve. J Neuro Met 135, 9-16
Sayegh AI, Covasa M, Ritter RC. 2004. Intestinal infusions of oleate and glucose activate distinct enteric neurons in the rat. Auton Neurosci 115: 54-63.
Li AJ, Ritter S 2004. Glucoprivation increases expression of neuropeptide Y mRNA in hindbrain neurons that innervate the hypothalamus. Eur. J. Neurosci. 19: 2147-2154.
Sorg BA, Swindell S, Tschirgi ML. 2004. Repeated low-level formaldehyde exposure produces enhanced fear conditioning to odor in male, but not female, rats. Brain Res.1008: 11-19.
Sorg BA, Li N, Wu WR. 2004. Activation of dopamine D1 receptors in the medial prefrontal cortex produces bidirectional effects on cocaine-induced locomotor activity in rats: effects of repeated stress. Neuroscience 127: 187-196.
Siegford JM, Ulibarri C. 2004 Jun 7. Increase in motoneurons in the spinal nucleus of the bulbocavernosus of prepubertally castrated male Mongolian gerbils following delayed treatment with testosterone. J Comp Neurol; 473(4): 485-95.
Peng C, Rich ED, Varnum MD. 2004. Subunit configuration of heteromeric cone cyclic nucleotide-gated channels. Neuron 42: 401-410.
Chen AV, Bagley RS, West CL, Gavin PR, Tucker RL. 2004. Fecal incontinence as a primary presenting complaint in 5 dogs with cystic abnormalities of the spinal cord. J Vet Int Med, 18:408.
Brandt JA, Churchill L, Rehman A, Ellis G, Memet S, Israel A, Krueger JM. 2004. Sleep deprivation increases the activation of Nuclear Factor kappa B in lateral hypothalamic cells. Brain Research 1004:91-97.
Peterfi Z, Churchill L, Hajdu I, Obal F Jr, Krueger JM, Parducz A. 2004. Fos-immunoreactivity in the hypothalamus: dependency on the diurnal rhythm, sleep, gender, and estrogen. Neuroscience 124(3):695-707.
Nelson SE, Duricka DL, Campbell K, Churchill L, Krueger JM. 2004. Homer 1a and 1bc levels in the rat somatosensory cortex vary with the time of day and sleep loss, Neurosci Lett 367:105-108.

Progress 01/01/03 to 12/31/03

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
Impact narrative has not been submitted. This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University.

Publications

Davis CJ, Harding JW, Wright JW. 2003. Sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus. Brain Res. 973: 293-297.
Krueger JM, Majde JA, Obal Jr F. 2003. Sleep in host defense. Brain Beh. Immunity 17: S41-S47.
Chen L, Majde JA, Krueger JM. 2003. Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. Brain Res. 973: 214-222.
Yoshida H, Kubota T, Krueger JM. 2003. A cyclooxygenase-2 inhibitor attenuates spontaneous and TNFalpha-induced non-rapid eye movement sleep in rabbits. Am. J. Physiol. 285: R99-R109.
De A, Krueger JM, Simasko SM. 2003. Tumor necrosis factor a increases cytosolic Ca++ responses to AMPA and KCl in primary cultures of rat hippocampal neurons. Brain Res. 981: 133-142.
Kushikata T, Kubota T, Fang J, Krueger JM. 2003. Neutrophin 3 and 4 enhance spontaneous sleep in rabbits. Neurosci. Lett. 346: 161-164.
Garcia-Garcia F, Krueger JM. 2003. Intracerebroventricular injection of erythropoietin enhances sleep in the rat. Brain Res. Bull. 61: 541-546.
Cearley C, Churchill L, Krueger JM. 2003. Time of day differences in IL1Beta and TNFalpha mRNA levels in specific regions of brain. Neurosci. Lett. 352: 64-66.
Hajdu I, Szentirmai E, Obal Jr F, Krueger JM. 2003. Different brain structures mediate drinking and sleep suppression elicited by the somatostatin analog, octreotide, in rats. Brain Res. 994: 115-123.
Richard CA, Rector DM, Macey PM, Ali N, Harper RM. 2003. Late-developing rostral ventrolateral medullary surface responses to cardiovascular challenges during sleep. Brain Res 985(1): 65-77.
Yao XC, Rector DM, George JS. 2003. Optical lever recording of displacements from activated lobster nerve bundles and Nitella internodes. Appl Opt 42(16): 2972-8.
Poe GR, Rector DM, Harper RM. 2003. State-dependent columnar organization of dorsal hippocampal activity in the freely behaving cat. Behav Brain Res 138(1): 107-12.
Fraley GS, Ritter S. 2003. Immunolesion of norephinephrine and epinephrine afferents to medial hypothalamus alters basal and 2DG-induced NPY and AGRP mRNA expression in the arcuate nucleus. Endocrinology 144:75-83.
Sayegh AI, Ritter RC. 2003. Cholecystokinin activates specific enteric neurons in the rat small intestine. Peptides 24: 237-244.
Obal Jr F, Alt J, Taishi P, Gardi J, Krueger JM. 2003. Sleep in mice with non-functional growth hormone (GH)-releasing hormone (GHRH) receptors. Am. J. Physiol. 284: R131-R139.
Cearley C, Churchill L, Krueger JM. 2003. Time of day differences in IL1Beta and TNFalpha mRNA levels in specific regions of the rat brain. Neurosci. Lett 352: 61-63.
Peng CH, Rich ED, Varnum MD. 2003. Achromatopsia-associated mutation in the cone photoreceptor cyclic nucleotide gated channel CNGB3 subunit alters the ligand sensitivity and pore properties of heteromeric channels. J. Biol. Chem. 278:34533-34540.
Jansen HT, Cutter C, Hardy S, Lehman MN, Goodman RL. 2003. Seasonal plasticity within the gonadotropin-releasing hormone (GnRH) system of the ewe: Changes in identified GnRH inputs and glial association. Endocrinology. 144:3663-3676.
Sanchez CJ, Bailie TM, Wu WR, Li N, Sorg BA. 2003. Manipulation of D1-like receptor activation in the rat medial prefrontal cortex alters stress- and cocaine-induced reinstatement of conditioned place preference behavior. Neurosci. 119:497-505.
Wu WR, Li N, Sorg BA. 2003. Prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and natural predatory odor challenge in rats. Brain Res 991:232-239.
Alt JA, Obal Jr F, Traynor TR, Gardi J, Majde JA, Krueger JM. 2003. Sleep responses to influenza viral infection in GHRH-receptor deficient mice. J. Appl. Physiol. 95: 460-468.
Covasa M, Ritter RC, Burns GA. 2003. Cholinergic neurotransmission participate in increased food intake induced by NMDA receptor blockade. Am J Physiol Regul Integr Comp Physiol 285: R641-648.
Wright JW, Masino AJ, Reichert JR, Turner GG, Meighan SE, Meighan PC, Harding JW. 2003. Ethanol-induced impairment of spatial memory and brain matrix metalloproteinases. Brain Res. 963: 252-261
Wright JW, Tamura-Myers E, Wilson WL, Roques BP, Llorens-Cortes C, Speth RC, Harding JW. 2003. Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284: R725-R733.
Sayegh AI, Ritter RC. 2003. Morphology and distribution of nitric oxide synthase-, neurokinin-1 receptor-, calretinin-, calbindin-, and neurofilament-M-immunoreactive neurons in the myenteric and submucosal plexuses of the rat small intestine. Anat Rec 271A: 209-216.
Simasko SM, Ritter RC. 2003. Cholecystokinin activates both A- and C-type vagal afferent neurons. Am J Physiol Gastrointest Liver Physiol 285: G1204-1213.
Ritter S, Watts AG, Dinh TT, Sanchez-Watts G, Pedrow C. 2003. Immunotoxin lesion of hypothalamically-projecting norepinephrine and epinephrine neurons differentially effects circadian and stressor-stimulated corticosterone secretion. Endocrinology 144 (4): 1357-1367.
I'Anson H, Sundling LA, Roland SM, Ritter S. 2003. Immunotoxic destruction of distinct catecholaminergic neuron populations disrupts the reproductive response to glucoprivation in female rats. Endocrinology; 144: 4325-4331.
Mansouri SH, Siegford JM, Ulibarri C. 2003. Early postnatal response of the spinal nucleus of the bulbocavernosus and target muscles to testosterone in male gerbils. Dev Brain Res. 142:129-139.
Siegford JM, Mansouri SH, Ulibarri C. 2003. Normal ontogeny of perineal muscles and testosterone levels in Mongolian gerbils; response to testosterone in developing females. Anat Rec 275A:997-1008.
Stoffel EC, Ulibarri C, Craft RM. 2003. Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats. Pain 103:285-302.
Peng CH, Rich ED, Thor CA, Varnum MD. 2003. Functionally important calmodulin binding sites in both N- and C-terminal regions of the cone photoreceptor cyclic nucleotide-gated channel CNGB3 subunit. J. Biol. Chem. 278:24617-24623.
Zheng J, Varnum MD, Zagotta WM. 2003. Disruption of an intersubunit interaction underlies Ca2+-calmodulin modulation of cyclic nucleotide-gated channels. J. Neuroscience 21:8167-8175.

Progress 01/01/02 to 12/31/02

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
(N/A)

Publications

Sorg, BA and Newlin, D.B. (2002) Sensitization as a mechanism for multiple chemical sensitivity: relationship to evolutionary game theory. Scand. J. Psychol. 43:161-167.
Sorg, BA, DL Davidson, T Hochstatter and PW Sylvester. (2002) Repeated cocaine decreases the avoidance response to a novel aversive stimulus. Psychopharmacol. 163: 9-19.
Wu, WR, N Li and BA Sorg. (2002) Regulation of the medial prefrontal cortex dopamine by alpha-amino-3-hydroxy-5-methylisoxozole-4-propionate/kainate receptors. Neurosci. 114:507-516.
Moulik, S, Speth RC, Turner, BB, Rowe BP. 2002. Angiotensin II receptor subtype distribution in the rabbit brain. Exp. Brain Res. 142: 275-283.
Speth, RC, Smith,MS and Grove, KL. 2002. Brain angiotensinergic mediation of enhanced water consumption in lactating rats. Am J. Physiol. 282: R695-701.
Gardi J, Taishi P, Speth RC, Obal F Jr. , Krueger JM. 2002. Sleep Loss Alters Hypothalamic Growth Hormone-Releasing Hormone Receptors. Neuroscience Letters 329: 69-72.
Gardi J, Speth RC Kacsoh B, Obal Jr F, Taishi P, Krueger JM. 2002. Alterations in GHRH binding in the pituitary of adult dw/dw dwarf rats. Peptides 23: 1497-1502.
Braileanu GT, Simasko SM, Speth RC, Daubert DL, Hu J, Mirando MA. 2002. Effect of oxytocin and angiotensin II on intracellular calcium concentration, phospholipase C activity and prostaglandin F2a in pig endometrial stromal cells. Reprod. Fertil. Dev. 14: 199-205.
Kearney, J.A., D.A. Buchner, G. de Haan, M. Adamska, S.I. Levin, A.R. Furay, R.L. Albin, J.M. Jones, M. Montal, M.J. Stevens, L.K. Sprunger, M.H. Meisler. (2002) Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a. Hum. Mol. Genet. 11(22): 2765-2775.
Fraley, G.S. and C. Ulibarri. 2002. Development of androgen receptor and p75NTR mRNAs and peptides in the lumbar spinal cord of the gerbil. Dev. Brain Res. 137:101-114.
Fraley, G.S. and C. Ulibarri. 2002. Long term castration effects motoneuron size but not number in the spinal nucleus of the bulbocavernosus in the adult male Mongolian gerbil. Brain Res. 953:265-271.
Prichett, L. C., C. Ulibarri, M.C. Roberts, R.K. Schneider, D.C. Sellon. 2002. Identification of potential physiological and behavioral indicators of postoperative pain in horses after exploratory celiotomy for colic. Appl. Anim. Behav. Sci.,80:31-43.
Romeo RD, Wagner CK, Jansen HT, Diedrich SL, Sisk CL. 2002. Estradiol induces hypothalamic progesterone receptors, but does not activate mating behavior in males prior to puberty. Behav. Neurosci. 116(2):198-205.
Hajdu, I., F. Obal Jr., J. Fang, J.M. Krueger, and C.D. Rollo. 2002. Sleep of transgenic mice producing excess rat growth hormone. Am. J. Physiol. 282: R70-R76.
Kubota, T., N. Li, Z. Guan, R. Brown, and J.M. Krueger. 2002. Intrapreoptic microinjection of TNF-alpha enhances Non-REM sleep in rats. Brain Res. 932: 37-44.
Kubota, T., A. De, R.A. Brown, S.M. Simasko, J.M. Krueger. 2002. Diurnal effects of acute and chronic administration of ethanol on sleep in rats. Alcohol. Clin. Exp. Res. 26: 1153-1161.
Gardi, J., R.C. Speth, P. Taishi, B. Kacsoh, F. Obol, Jr., and J.M. Krueger. 2002. Alterations in GHRH binding in the pituitary of adult dw/dw rats. Peptides 23: 1497-1502.
Gardi, J., P. Taishi, R. Speth, F. Obal Jr. and J.M. Krueger. 2002. Sleep loss alters hypothalamic growth hormone releasing hormone receptors. Neurosci. Lett. 320: 69-72.
De, A., L. Churchill, F. Obal Jr., S.M. Simasko, and J.M. Krueger. 2002. GHRH and IL1Beta increase cytoplasmic Ca-2+ levels in cultured hypothalamic GABAergic neurons. Brain Res. 949: 209-212.
Poe, G.R., Rector, D.M. and Harper, R.M. 2002. State-dependent columnar organization of dorsal hippocampal activity in the freely-behaving cat. Behavioural Brain Research 138:107-112.
Simasko, SM., R. C. Ritter, et al. 2002. Chloecystokinin increases cytosolic calcium in a subpopulation of cultured vagal afferent neurons. Am J Physiol Regul Integr Comp Physiol 283(6): R1303-13.
Matson, C.A., D.F. Reid and R.C. Ritter. 2002. Daily CCK injection enhances reduction of body weight by chronic intracerebroventricular leptin infusion. Am J Physol Regl Integr Comp Physiol 282(5): R1368-73.
Fraley, GS, Dinh, TT, and Ritter, S. 2002. Immunotoxic catecholamine lesions attenuate 2DG-induced increase in AGRP mRNA. Peptides 6397:1-8.
Zhou X, Ren J, Brown E, Schneider D, Caraballo-Lopez Y, Galligan JJ. 2002. Pharmacological properties of nicotinic acetylcholine receptors expressed by guinea pig small intestinal myenteric neurons. J Pharmacol Exp Ther Sep;302(3):889-97
Braileanu, G.T., S.M. Simasko, R.C. Speth, D. Daubert, J. Hu, and M.A. Mirando (2002) Angiotensin II increases intracellular calcium concentrations in pig endometrial stromal cells through type 1 angiotensin receptors, but does not stimulate phospholipase C activity or prostaglandin F2a secretion. Reprod. Fertil. Dev. 14: 1-7.
Kubota, T., A. De, R.A. Brown, S.M. Simasko, and J.M. Krueger (2002) Diurnal effects of acute and chronic administration of ethanol on sleep in rats. Alcoholism: Clin. Exp. Res. 26: 1153-1161.
De, A., L. Churchill, F. Obal Jr., S.M. Simasko, and J.M. Krueger (2002) GHRH and IL1b increase cytoplasmic Ca2+ levels in cultured hypothalamic GABAergic neurons. Brain Res. 949: 209-212.
Wright, J.W., Kramar, E.A. Meighan, S.E., and Harding, J.W. 2002. Extracellular matrix molecules, long-term potentiation, memory consolidation and the brain angiotensin system. Peptides 23: 221-246.
Wright, J.W., Reichert, J.R., Davis, C.J., and Harding, J.W. 2002. Neural plasticity and the brain renin-angiotensin system. Neurosci. and Biobehav. Rev. 26: 529-552.
De, A., L. Churchill, F. Obal, Jr, S.M. Simasko, and J.M. Krueger. 2002. GHRH and IL1b increase cytoplasmic Ca2+ levels in cultured hypothalamic GABAergic neurons. Brain Research 949: 209-212.

Progress 01/01/01 to 12/31/01

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
(N/A)

Publications

Churchill L, Taishi P, Guan Z, Chen L, Fang J, Krueger JM. 2001. Sleep modifies glutamate decarboxylase mRNA within the barrel cortex of rats after a mystacial whisker trim. Sleep. 1;24(3):261-6.
Brandt JA, Churchill L, Guan Z, Fang J, Chen L, Krueger JM. 2001. Sleep deprivation but not a whisker trim increases nerve growth factor within barrel cortical neurons. Brain Res. Apr 13;898(1):105-12.
Wayner MJ, Armstrong DL, Phelix CF, Wright JW, Harding JW. 2001. Angiotensin IV enhances LTP in rat dentate gyrus in vivo. Peptides. Sep;22(9):1403-14.
Taishi P, Sanchez C, Wang Y, Fang J, Harding JW, Krueger JM. 2001. Conditions that affect sleep alter the expression of molecules associated with synaptic plasticity. Am J Physiol Regul Integr Comp Physiol. Sep;281(3):R839-45.
Kramar EA, Armstrong DL, Ikeda S, Wayner MJ, Harding JW, Wright JW. 2001. The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Brain Res. Apr 6;897(1-2):114-21.
Jansen HT, West C, Lehman MN, Padmanabhan V. 2001. Ovarian estrogen receptor-beta (ERbeta) regulation: I. Changes in ERbeta messenger RNA expression prior to ovulation in the ewe. Biol Reprod. Sep;65(3):866-72.
Viguie C, Jansen HT, Glass JD, Watanabe M, Billings HJ, Coolen L, Lehman MN, Karsch FJ. 2001. Potential for polysialylated form of neural cell adhesion molecule-mediated neuroplasticity within the gonadotropin-releasing hormone neurosecretory system of the ewe. Endocrinology. Mar;142(3):1317-24.
Seta KA, Jansen HT, Kreitel KD, Lehman M, Behbehani MM. 2001. Cold water swim stress increases the expression of neurotensin mRNA in the lateral hypothalamus and medial preoptic regions of the rat brain. Brain Res Mol Brain Res. Jan 31;86(1-2):145-52.
Kubota T, Fang J, Meltzer LT, Krueger JM. 2001. Pregabalin enhances nonrapid eye movement sleep. J Pharmacol Exp Ther. Dec;299(3):1095-105.
Kubota T, Majde JA, Brown RA, Krueger JM. 2001. Tumor necrosis factor receptor fragment attenuates interferon-gamma-induced non-REM sleep in rabbits. J Neuroimmunol. Oct 1;119(2):192-8.
Obal F Jr, Fang J, Taishi P, Kacsoh B, Gardi J, Krueger JM. 2001. Deficiency of growth hormone-releasing hormone signaling is associated with sleep alterations in the dwarf rat. J Neurosci. Apr 15;21(8):2912-8.
Rehman A, Taishi P, Fang J, Majde JA, Krueger JM. 2001. The cloning of a rat peptidoglycan recognition protein (PGRP) and its induction in brain by sleep deprivation. Cytokine. Jan 7;13(1):8-17.
Newberry RC, Estevez I, Keeling LJ. 2001. Group size and perching behaviour in young domestic fowl. Appl Anim Behav Sci. Jul 28;73(2):117-129.
Ritter S, Bugarith K, Dinh TT. 2001. Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation. J Comp Neurol. Apr 2;432(2):197-216.
Sanchez CJ, Sorg BA. 2001. Conditioned fear stimuli reinstate cocaine-induced conditioned place preference. Brain Res. Jul 20;908(1):86-92.
Sorg BA, Bailie TM, Tschirgi ML, Li N, Wu WR. 2001. Exposure to repeated low-level formaldehyde in rats increases basal corticosterone levels and enhances the corticosterone response to subsequent formaldehyde. Brain Res. Apr 20;898(2):314-20.
Sorg BA, Li N, Wu WR. 2001. Dopamine D1 receptor activation in the medial prefrontal cortex prevents the expression of cocaine sensitization. J Pharmacol Exp Ther. May;297(2):501-8.
Wayment HK, Schenk JO, Sorg BA. 2001. Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition. J Neurosci. Jan 1;21(1):35-44.
Speth RC, Smith MS, Grove KL. 2001. Lactation decreases angiotensinogen mRNA expression in the midcaudal arcuate nucleus of the rat brain. Am J Physiol Regul Integr Comp Physiol. Apr;280(4):R1169-76.
Meisler MH, Kearney J, Escayg A, MacDonald BT, Sprunger LK. 2001. Sodium channels and neurological disease: insights from Scn8a mutations in the mouse. Neuroscientist. Apr;7(2):136-45. Review.
Maurice N, Tkatch T, Meisler M, Sprunger LK, Surmeier DJ. 2001. D1/D5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons. J Neurosci. Apr 1;21(7):2268-77.
Fraley GS, Ulibarri C. 2001. Sexual dimorphism in the number and size of SNB motoneurons: delayed development during normal ontogeny. Brain Res Dev Brain Res. Jan 31;126(1):57-64.

Progress 01/01/00 to 12/31/00

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
(N/A)

Publications

Craft RM, Ulibarri CM, Raub DJ. 2000. Kappa opioid-induced diuresis in female vs. male rats. Pharmacol Biochem Behav 65(1):53-9.
Knierim JJ, McNaughton BL, Poe GR. 2000. Three-dimensional spatial selectivity of hippocampal neurons during space flight. Nat Neurosci 3(3):209-10.
Krebs, L.T., J.M. Hanesworth, M.F. Sardinia, R.C. Speth, J.W. Wright, and J.W. Harding. 2000. A novel angiotensin analog with subnanomolar affinity for angiotensin-converting enzyme. J Pharmacol Exp Ther 293(1):260-7.
Moulik S, Speth RC, Rowe BP. 2000. Differential loss in function of angiotensin II receptor subtypes during tissue storage. Life Sci. 66(16):PL233-7.
Poe GR, Nitz DA, McNaughton BL, Barnes CA. 2000. Experience-dependent phase-reversal of hippocampal neuron firing during REM sleep. Brain Res. 855(1):176-80.
Poe GR, Teed RG, Insel N, White R, McNaughton BL, Barnes CA. 2000. Partial hippocampal inactivation: effects on spatial memory performance in aged and young rats. Behav Neurosci. 114(5):940-9.
Renegar KB, Crouse D, Floyd RA, Krueger J. 2000. Progression of influenza viral infection through the murine respiratory tract: the protective role of sleep deprivation. Sleep. 23(7):859-63.
Ritter S, Dinh TT, Zhang Y. 2000. Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res. 856(1-2):37-47.
Sanders NM, Ritter S. 2000. Repeated 2-deoxy-D-glucose-induced glucoprivation attenuates Fos expression and glucoregulatory responses during subsequent glucoprivation. Diabetes. 49(11):1865-74.
Sayegh AI, Ritter RC. 2000. CCK-A receptor activation induces fos expression in myenteric neurons of rat small intestine. Regul Pept. 88(1-3):75-81.
Sayegh AI, Ritter RC. 2000. Vagus nerve participates in CCK-induced fos expression in hindbrain but not myenteric plexus. Brain Res. 878(1-2):155-62.
Schneider, D.A., M. Perrone, and J.J. Galligan. 2000. Nicotinic acetylcholine receptors at sites of neurotransmitter release to the guinea pig intestinal circular muscle. J. Pharmacol. Exp. Ther. 294: 363-369.
Treece BR, Ritter RC, Burns GA. 2000. Lesions of the dorsal vagal complex abolish increases in meal size induced by NMDA receptor blockade. Brain Res. 872(1-2):37-43.
Covasa M, Grahn J, Ritter RC. 2000. High fat maintenance diet attenuates hindbrain neuronal response to CCK. Regul Pept 86(1-3):83-8.
Covasa M, Grahn J, Ritter RC. 2000. Reduced hindbrain and enteric neuronal response to intestinal oleate in rats maintained on high-fat diet. Auton Neurosci 84(1-2):8-18.

Progress 01/01/99 to 12/31/99

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
(N/A)

Publications

Kushikata T, Fang J, Krueger JM. 1999. Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits. Am J Physiol. 276(5 Pt 2):R1334-8.
Takahashi S, Kapas L, Fang J, Krueger JM. 1999. Somnogenic relationships between tumor necrosis factor and interleukin-1. Am J Physiol. 276(4 Pt 2):R1132-40.
Zhang J, Obal F Jr, Zheng T, Fang J, Taishi P, Krueger JM. 1999. Intrapreoptic microinjection of GHRH or its antagonist alters sleep in rats. J Neurosci. 19(6):2187-94.
Wright JW, Stubley L, Pederson ES, Kramar EA, Hanesworth JM, Harding JW. 1999. Contributions of the brain angiotensin IV-AT4 receptor subtype system to spatial learning. J Neurosci. 19(10):3952-61.
Beranek L, Hajdu I, Gardi J, Taishi P, Obal F Jr, Krueger JM. 1999. Central administration of the somatostatin analog octreotide induces captopril-insensitive sleep responses. Am J Physiol. 277(5 Pt 2):R1297-304.
Hansen MK, Krueger JM. 1999. Gadolinium chloride pretreatment prevents cafeteria diet-induced sleep in rats. Sleep. 22(6):707-15.
Pabst MJ, Beranova-Giorgianni S, Krueger JM. 1999. Effects of muramyl peptides on macrophages, monokines, and sleep. Neuroimmunomodulation. 6(4):261-83. Review.
Krueger JM, Obal F Jr, Fang J. 1999. Humoral regulation of physiological sleep: cytokines and GHRH. J Sleep Res. 8 Suppl 1:53-9. Review.
Bagley RS, Gavin PR. 1999. Advanced neuroimaging. Cornell Feline Health Topics, 14:1-5.
O'Rourke KI, Besser TE, Miller MW, Cline TF, Spraker TR, Jenny AL, Wild MA, Zebarth GL, Williams ES. 1999. PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervas ealphus nelsoni) with chronic wasting disease. Journal of General Virology 80:2765-2769.
Churchill, L., C.J. Swanson, M. Urbina and P.W. Kalivas. 1999. Repeated cocaine alters glutamate receptor subunit levels in the nucleus accumbens and ventral tegmental area of rats that develop behavioral sensitization. J. Neurochem. 72(6): 2397-2403.
Churchill, L. and P.W. Kalivas. 1999. The involvement of the mediodorsal nucleus of the thalamus and midbrain extrapyramidal area in locomotion elicited from the ventral pallidum. Behav. Brain Res. 104: 63-71.
Kalivas, PW. Churchill, L. and Romanides, A. 1999. Involvement of the pallidal-thalamocortical circuit an adaptive behavior. Ann N Y Acad Sci. 877: 64-70.
Roky R, Kapas L, Taishi TP, Fang J, Krueger JM. 1999. Food restriction alters the diurnal distribution of sleep in rats. Physiol Behav. 67(5):697-703.
Gardi J, Obal F Jr, Fang J, Zhang J, Krueger JM. 1999. Diurnal variations and sleep deprivation-induced changes in rat hypothalamic GHRH and somatostatin contents. Am J Physiol. 277(5 Pt 2):R1339-44.
Kushikata T, Fang J, Krueger JM. 1999. Interleukin-10 inhibits spontaneous sleep in rabbits. J Interferon Cytokine Res. 19(9):1025-30.
Chen Z, Gardi J, Kushikata T, Fang J, Krueger JM. 1999. Nuclear factor-kappaB-like activity increases in murine cerebral cortex after sleep deprivation. Am J Physiol. 276(6 Pt 2):R1812-8.
Takahashi S, Krueger JM. 1999. Nerve growth factor enhances sleep in rabbits. Neurosci Lett. 264(1-3):149-52.
Obal F Jr, Kapas L, Gardi J, Taishi P, Bodosi B, Krueger JM. 1999. Insulin-like growth factor-1 (IGF-1)-induced inhibition of growth hormone secretion is associated with sleep suppression. Brain Res. 818(2):267-74.
Krueger, J.M. and J. Fang. 1999. Cytokines and sleep regulation. In: Handbook of Behavioral State Control. R. Lydic and H.A. Baghdoyan (eds.). CRC Press: Boca Raton, FL; pp. 609-622.
Krueger, J.M., R.A. Floyd, and J. Fang. 1999. Relationships between sleep and immune function. In: Regulation of Sleep and Circadian Rhythms. F.W. Turek and P.C. Zee (eds.). Marcel Dekker, Inc.: New York, NY pp. 427-464.
Simasko SM, Boyadjieva N, De A, Sarkar DK. 1999. Effect of ethanol on calcium regulation in rat fetal hypothalamic cells in culture. Brain Res. 824(1):89-96.
Sorg BA, Hochstatter T. 1999. Behavioral sensitization after repeated formaldehyde exposure in rats. Toxicol Ind Health. 15(3-4):346-55.
Prasad BM, Hochstatter T, Sorg BA. 1999. Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Neuroscience. 88(3):765-74.
Kalivas, P.W., R.C. Pierce and B.A. Sorg. 1999. A role for sensitization in psychostimulant-induced paranoia and psychosis. In: Interactive Monaminergic Disorders. RJ Beninger, T Palomo, and T Archer, eds. CYM Press: Madrid, Spain; pp. 453-460.
Speth RC, Barry WT, Smith MS, Grove KL. 1999. A comparison of brain angiotensin II receptors during lactation and diestrus of the estrous cycle in the rat. Am J Physiol. 277(3 Pt 2):R904-9.
Speth RC, Daubert DL, Grove KL. 1999. Angiotensin II: a reproductive hormone too? Regul Pept. 79(1):25-40. Review.
Daubert DL, Meadows GG, Wang JH, Sanchez PJ, Speth RC. 1999. Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res. 816(1):8-16.
Crews, E.C., R.C. Speth and N. E. Rowland. 1999. Dietary NaCl during pregnancy and lactation: Effect on brain Ang II receptors and behavior. Behav. Neurosci 113: 1090-1094.
McSweeney FK, Swindell S. 1999. Behavioral economics and within-session changes in responding. J Exp Anal Behav. 72(3):355-71.

Progress 01/01/98 to 12/31/98

Outputs
This is an umbrella project for neurobiology research in the College of Veterinary Medicine at Washington State University. Progress in this project is detailed in the publications listed below.

Impacts
(N/A)

Publications

Burns, G.A., L.G. Fleischmann and R.C. Ritter. 1998. MK-801 interferes with nutrient-related signals for satiation. Appetite. 30(1): 1-12.
Burns, G.A. and R.C. Ritter. 1998. Visceral afferent participation in delayed satiation following NMDA receptor blockade. Physiol. Behav. 65(2): 361-366.
Treece, B.R., M. Covasa, R. Ritter and G.A. Burns. 1998. Delay in meal termination follows blockade of N-methyl-D-aspartate receptors in the dorsal hindbrain. Brain Res. 810(1): 34-40.
Hansen, M., L. Kapas, J. Fang, and J.M. Krueger. 1998. Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats. Am. J. Physiol. 274: R168-R174.
Kapas, L., M.K. Hansen, H.-Y. Chang, and J.M. Krueger. 1998. Vagotomy attenuates but does not prevent somnogenic and febrile effects of lipopolysaccharide in rats. Am. J. Physiol. 274: R406-R411.
Renegar, K.B., R. Floyd, and J.M. Krueger. 1998. Effect of sleep deprivation on serum influenza-specific IgG. Sleep. 21: 19-24.
Kushikata, T., S. Takahashi, Y. Wang, J. Fang and J.M. Krueger. 1998. An interleukin-1 receptor fragment blocks ambient temperature-induced increases in brain temperature but not sleep in rabbits. Neurosci. Lett. 244: 125-128.
Brenner, L.A., and R.C. Ritter. 1998. CCK-A receptor antagonist is more effective peripherally than centrally for attenuation of suppression of sham feeding by intestinal oleate. Physiol. Behav. 63(4): 711-716.
Covasa, M. and R.C. Ritter. 1998. Rats maintained on high-fat diets exhibit reduced satiety in response to CCK and bombesin. Peptides 19(8): 1407-1415.
Koegler, F.H. and S. Ritter. 1998. Injection of galanin into the nucleus of the solitary tract (NTS) stimulates feeding in rats with lesions of the paraventricular nucleus of the hypothalamus. Phys. Behav. 63: 521-528.
Ritter, S., Llewellyn-Smith, I., Dinh, T.T. 1998. Subgroups of hindbrain catecholamine neurons are selectively activated by 2-deoxy-D-glucose induced metabolic challenge. Brain Research 805: 41-54.
Sankaranarayanan, S. and S.M. Simasko. 1998. Potassium channel blockers have minimal effect on repolarization of spontaneous action potentials in rat pituitary lactotrophs. Neuroendocrinology 68: 297-311.
Prasad, B.M., C. Ulibarri and B.A. Sorg. 1998. Stress-induced cross-sensitization to cocaine: Effects of adrenalectomy and corticosterone after short- and long-term withdrawal. Psychopharm. 125: 265-273.

Progress 01/01/97 to 12/31/97

Outputs
Progress in this project is detailed in the publications listed below.

Impacts
(N/A)

Publications

LU X-Y, CHURCHILL L and KALIVAS PW. 1997. Expression of D1 receptor mRNA in projections from the forebrain to the ventral tegmental area. Synapse, 25:205-214.
TAKAHASHI S, FANG J, KAPAS L, WANG Y, KRUEGER JM. 1997. Inhibition of brain interleukin-1 attenuates sleep rebound after sleep deprivation in rabbits. Am. J. Physiol. 42:R677-R682.
FANG J, WANG Y, KRUEGER JM. 1997. Mice lacking the TNF 55-kD receptor fail to sleep more after TNFa treatment. J. Neurosci. 17:5949-5955.
KRAMAR EA, HARDING JW, WRIGHT JW. 1997. Angiotensin II and IV-induced changes in cerebral blood flow: Roles of AT1, AT2 and AT4 receptor subtypes. Regul. Pept. 68:131-138.
WRIGHT JW, BECHTOLT AJ, CHAMBERS SL, HARDING JW. 1997. Angiotensin III and IV activation of the brain AT1 receptor subtype. Peptides 17:1365-1371.
LU X-Y, GHASEMZADEH B and KALIVAS PW. 1997. Expression of D1, D2, substance P and enkephalin mRNA in subpopulations of neurons in the nucleus accumbens. Neuroscience 82:767-780.
AYERS NA, KAPAS L, KRUEGER JM. 1997. The inhibitory effects of N-nitro-L-arginine methyl ester on nitric oxide synthase activity vary among brain regions in vivo but not in vitro. Neurochem. Res. 22:81-86.
TAISHI P, BREDOW S, GUHA-THAKURTA N, OBAL JR. F, KRUEGER JM. 1997. Diurnal variations of interleukin-1B mRNA and B-actin mRNA in rat brain. J. Neuroimmunol. 75:69-74.
OBAL, JR. F, KACSOH B, BREDOW S, GUHA-THAKURTA N, KRUEGER JM. 1997. Sleep in rats rendered chronically hyperprolactinemic with anterior pituitary grafts. Brain Res. 755:130-136.
FLOYD RA, KRUEGER JM. 1997. Diurnal variations of TNFa in the rat brain. NeuroReport. 8:915-918.
BERDLOW S, TAISHI P, GUHA-THAKURTA N, OBAL, JR. F, KRUEGER JM. 1997. Diurnal variations of tumor necrosis factor-a mRNA and a-tubulin mRNA in rat brain. J. NeuroImmuno Modulation 4:84-90.
BURNS GA, RITTER RC. 1997. The non-competitive NMDA antagonist MK-801 increases food intake in rats. Pharm. Biochem. Behav. 56(1):145-149.
JAGGER A, GRAHN J, RITTER RC. 1997. Reduced vagal sensory innervation of the intestinal myenteric plexus following capsaicin treatment of adult rats. Neuroscience Lett. 236(2):103-106.

Progress 01/01/96 to 12/30/96

Outputs
Progress in this project is detailed in the publications listed below.

Impacts
(N/A)

Publications

CHURCHILL, L., ZAHM, D. S., AND KALIVAS, P.W. 1996. The mediodorsal nucleus of the thalamus. I. Forebrain GABAergic innervation. Neurosci. 70: 93-102.
CHURCHILL, L., ZAHM, D.S., DUFFY, T. AND KALIVAS, P.W. 1996. The mediodorsal nucleus of the thalamus. II. Behavioral and neurochemical effects of GABA agonists. Neurosci. 70: 103-112.
KOEGLER, F.H. AND S. RITTER. 1996. Feeding induced by pharmacological blockade of fatty acid metabolism is selectively attenuated by hindbrain injections of the galanin receptor antagonist, M40. Obesity Res. 4: 329-336.
OBRADOVIC, T., K.M. IMEL AND S.R. WHITE. 1996. Methylenedioxymethamphetamine-induced inhibition of neuronal firing in the nucleus accumbens is mediated by both serotonin and dopamine. Neuroscience, 74: 469-481.

Progress 01/01/95 to 12/30/95

Outputs
Progress in this project is detailed in the publications listed below.

Impacts
(N/A)

Publications

Progress 01/01/94 to 12/30/94

Outputs
Progress in this project is detailed in the publications listed below.

Impacts
(N/A)

Publications

HOOKS MS, JB JUSTICE JR., JL JUNCOS, AND PW KALIVAS. 1994. Individual locomotor response to novelty predicts selective alterations in D1 and D2 receptors and mRNAs. J. Neurosci. 14(10):6144-6152.
RITTER S, TT DINH, AND MI FRIEDMAN. 1994. Induction of Fos-like immunoreactivity (Fos-li) and stimulation of feeding by 2,5-anhydro-D-mannitol (2,5-AM) require the vagus nerve. Brain Res. 646:53-64.
WHITE SR, P DUFFY, AND PW KALIVAS. 1994. Effects of MDMA on neuronal excitability and extracellular levels of dopamine and serotonin in nucleus accumbesn in vivo. Neuroscience 62:41-50.
ANDRE P, F FASCETTI, O POMPEIANO AND SR WHITE. 1994. The muscarinic agonist bethanechol enhances GABA-induced inhibition of Purkinje cells in the cerebellar cortex. Brain Res. 637:1-9.
HOOKS MS, BA SORG, AND PW KALIVAS. 1994. The relationship between mRNA levels and the locomotor response to novelty. Brain Res. 663:312-316.

Progress 07/01/90 to 06/30/94

Outputs
Objectives: Identify, characterize, & resolve pathophysiologic process of the central peripheral, & autonomic nervous systems. Approach: Utilize characterized & controlled in vivo & in vitro systems to study normal physiologic pathways & mechanisms. Utilize these same systems to study response to spontaneous & induced alterations. Progress towards reaching the objectives is listed in the publications.

Impacts
(N/A)

Publications

NO PUBLICATIONS REPORTED THIS PERIOD.

Progress 01/01/92 to 12/30/92

Outputs
Objectives: Identify, characterize, & resolve pathophysiologic process of the central peripheral, & autonomic nervous systems. Approach: Utilize characterized & controlled in vivo & in vitro systems to study normal physiologic pathways & mechanisms. Utilize these same systems to study response to spontaneous & induced alterations. Progress towards reaching the objectives is listed in the publications listed below.

Impacts
(N/A)

Publications

GREENE SA, ET AL. 1992. Quantitative electroencephalography for measurement of central nervous system responses to diazepam and benzodiazepine antagonist, flumazenil, (etc). J Vet Pharm Ther 15:259-266.
DANIEL GB, ET AL. 1992. Brain scintigraphy. Prog Vet Neuro 3:25-34.
ZHUO H, ET AL. 1992. Immunohistochemical evidence for coexistence of mithionine-enkephalin & tyrosine hydroxylase in neurons of the locus coeruleus complex projecting to the spinal cord in the cat. J Chem Neuroanat 5:1-10.
SKEEN RS, ET AL. 1992. Effect of temperature & analyze application technique on neuron-based chemical sensing. Biosen Bioelec 7:91-101.
BRISKI KP, ET AL. 1992. Differential impact of naltrexon on luteinizing hormone release during single versus repetitive exposure to restraint stress. Psychoneuroendocrinology 17:125-133.
BRISKI KP, ET AL. 1992. Inhibition of pituitary bioactive prolactin secretion in the male rat by the glucocorticoid agonist decadron phosphate. Biol Reprod 47:478-484.
CAMPBELL KB, ET AL. 1992. Single perturbed beat vs steady-state beats for assessing systolic mechanical function in the isolated heart. Am J Physiol 262:H1631-H1639.
CHURCHILL L, ET AL. 1992. Autoradiographic localization of gamma-aminobutyric acid-A receptors within the ventral tegmental area. Neurochem Res 17:101-106.

Progress 01/01/91 to 12/30/91

Outputs
Objectives: Identify, characterize, & resolve pathophysiologic process of the central peripheral, & autonomic nervous systems. Approach: Utilize characterized & controlled in vivo & in vitro systems to study normal physiologic pathways & mechanisms. Utilize these same systems to study response to spontaneous & induced alterations. Progress toards reaching thee objectives is listed in the publications listed below.

Impacts
(N/A)

Publications

REDDY VK, ET AL. 1991. Pontospinal transmitters and their distribution. Prog Brain Res 88:103-122.
WHITE SR, ET AL. 1991. Norepinephrine effects on spinal motoneurons. Prog Brain Res 88:343-350.
FUNG SJ, ET AL. 1991. Locus coreuleus control of spinal motor output. Prog Brain Res 88:395-410.
HEIMER L, ET AL. 1991. Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience 41:89-125.
CHURCHILL L, ET AL. 1991. GABAa receptors containing alpha 1 and beta 2 subunits are mainly localized on neurons in the ventral pallidum. Synapse 8:75-85.
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COOK VI, ET AL. 1991. The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain. Brain Res 560:334-336.
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POMPEIANO O, ET AL. 1991. Responses of locus coeruleus neurons to labyrinth and neck stimulation. Prog Brain Res 88:411-434.

Progress 12/01/89 to 12/30/90

Outputs
Objectives: Identify, characterize, & resolve pathophysiologic process of the central peripheral, & autonomic nervous systems. Approach: Utilize characterized & controlled in vivo & in vitro systems to study normal physiologic pathways & mechanisms. Utilize these same systems to study response to spontaneous & induced alterations. Progress toards reaching thee objectives is listed in the publications listed below.

Impacts
(N/A)

Publications