Source: UNIV OF CALIFORNIA (VET-MED) submitted to NRP
SMALL RUMINANT LENTIVIRUS PROMOTER SEQUENCE DETERMINES DISEASE OUTCOME
Sponsoring Institution
Cooperating Schools of Veterinary Medicine
Project Status
ACTIVE
Funding Source
STATE
Reporting Frequency
Annual
Accession No.
1033794
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
May 1, 2025
Project End Date
Jun 30, 2026
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
UNIV OF CALIFORNIA (VET-MED)
(N/A)
DAVIS,CA 95616
Performing Department
Pathology, Microbiology & Immunology
Non Technical Summary
The majority of goats with naturally acquired CAEV infections do not demonstrate disease (arthritis) and relatively few goats demonstrate neurological disease. The reason(s) for this are poorly understood but may relate to: 1. host genetics, 2. viral genetics, 3. environmental factors. We are testing the second hypothesis.
Animal Health Component
10%
Research Effort Categories
Basic
90%
Applied
10%
Developmental
0%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
30838201101100%
Knowledge Area
308 - Improved Animal Products (Before Harvest);

Subject Of Investigation
3820 - Goats, meat, and mohair;

Field Of Science
1101 - Virology;
Goals / Objectives
Determine if CAEV promoter sequences are associated with disease outcome in goats with neurological CAEV.
Project Methods
Identify clinical cases in the UC Davis and CAHFS databasesIsolate DNA, PCR amplify the CAEV promoterClone and sequenceCompare sequences to prior data