Non Technical Summary
A better understanding of nutrient sensing and signalingwill led to newinterventionsto prevent or delay the onset of metabolic disorders and chronic diseases. This conference proposaldirectly supports the AFRI Food Safety, Nutrition, and Health program under the Diet, Nutrition and the Prevention of Chronic Diseases area and addresses the priority "Develop, implement and evaluate innovative research strategies to improve eating patterns that prevent and control diet-related chronic diseases" and the priority approach "Precision nutrition" (A1344).As a result of this conference, new approaches to study diet and measure metabolism will be discussed in an interdisciplinary setting, leading to new and different research partnerships.Nutrient sensingand signaling arekey mechanisms in the development of insulin resistance, metabolic syndrome, obesity, dyslipidemia, metabolic associated liver steatosis, cardiovascular disease, cancer, diabetes, neurological disease, sarcopenia and cachexia.The proposed conference will bring together scientists from multiple disciplines with a common interest in nutrient sensing and the regulation of metabolism and cell function by nutrients. In this way, investigators using more inter-organ and holistic approaches can share expertise with those whose research focuses more on a cellular or molecular level, and vice versa.All of the planned conference sessions cover concepts that are highly relevant to precision/personalized nutrition and diet-related chronic disease. The lineup of scientific session chairs and invited speakers includesracial/ethnic minorities, LGBTQ+, geographic diversity, and othergroupsunderrepresented in science. Formal and informal events are planned to facilitate new collaborations and create a change in knowledge among the attendees.

Classification

Knowledge Area (KA)	Subject of Investigation (SOI)	Field of Science (FOS)	Percent
302	3999	1010	20%
305	3999	1020	20%
306	3999	1060	20%
301	3999	1010	10%
311	3999	1060	20%
304	3999	1080	10%

Knowledge Area
302 - Nutrient Utilization in Animals; 311 - Animal Diseases; 305 - Animal Physiological Processes; 306 - Environmental Stress in Animals; 304 - Animal Genome; 301 - Reproductive Performance of Animals;

Subject Of Investigation
3999 - Animal research, general;

Field Of Science
1060 - Biology (whole systems); 1010 - Nutrition and metabolism; 1080 - Genetics; 1020 - Physiology;

Goals / Objectives
Nutrient sensing and signaling are key factors in the development of chronic diseases. The overarching goal of this four-day conference, Nutrient Sensing and Signaling in Metabolism, is to advance the scientific underpinnings of diet, nutrition, and chronic disease prevention by sharing and discussing research progress on the molecular basis of nutrient action. The goal requires time and space to understand the current science and knowledge in this area, aided by facilitated conversations and organized venues to allow for open sharing, and intentional programming so all attendees feel they are included and have a voice in the discussion. To do this we plan to bring together scientists from multiple disciplines with a common interest in nutrient sensing and the regulation of metabolism and cell function by nutrients. In this way, investigators using more inter-organ and holistic approaches can share expertise with those whose research focuses more on a cellular or molecular level, and vice versa. Furthermore, the decision to frame sessions not only by nutrient sensing and signaling pathways but also by nutrition-related metabolic diseases allows for another level of cross-functional interaction.The specific objectives of this conference are to:1) Conduct a keynote lecture plus nine scientific sessions covering innovative experimental approaches and tools and sharingknowledge on how nutrient and sensing and signaling are regulated during health and during the development of chronic diseases.2) Conduct two career developent workshopsto provide guidance and support for junior and early-career investigators, trainees, women, and those from historically excluded groups.3) Conduct two poster discussions to promote networking between emerging and established investigators.4) Conduct daily "Meet the Expert" round table discussions to share knowledge,and promote networking and collaboration.The above objectives will advance current knowledge, encourage new and different research partnerships that lead to future grant submissions, and support a culture that is moreinclusive of individuals historically marginalized in scientific research.

Project Methods
Efforts to deliver science-based knowledge toconference attendees will consist of both formal and informal programs. The formal programs include: 1) the keynote lecture;2) nine scientific sessions thatinclude both invited talks and selected short talks chosen from submitted abstracts;3) viewing and discussion ofposter presentations; 4) twointeractive Career Development workshops; and5) "Meet the Expert" roundtable opportunities for discussion.Informal programs consist of 1)free time during breaks to discuss scienceand 2) outside excursionsto provide opportunities forinteraction and connection in a more casual setting.Evaluation of the above will occurduring a formal Business Meeting at the conference and via anattendee surveyfollowing completion of the conference.