Source: CORNELL UNIVERSITY submitted to NRP
ANTIMICROBIAL RESISTANCE
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
1021097
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
NC-_old1206
Project Start Date
Jan 3, 2020
Project End Date
Sep 30, 2022
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
CORNELL UNIVERSITY
(N/A)
ITHACA,NY 14853
Performing Department
Applied Economics & Management
Non Technical Summary
There are alternatives to extensive antimicrobial use to prevent or treat sick animals in cattle feedlots. One such alternative is preconditioning where calves are vaccinated and started on feedlot rations and facilities before movement to feedlots. This preconditioning of calves should reduce the incidence of illness and use of antimicrobials to treat these illnesses in feedlots. However, the use of preconditioning of calves is not universality used in the industry. One reason for non-use might be insufficient knowledge concerning the benefits of preconditioning and verification, and thus insufficient payment to preconditioners. We will estimate the net benefits of preconditioning and construct contracts (mechanisms) to make use of preconditioning attractive to the industry. The economic impact of additional alternatives to extensive antimicrobial will be evaluated.
Animal Health Component
100%
Research Effort Categories
Basic
0%
Applied
100%
Developmental
0%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
60133103010100%
Goals / Objectives
Develop and evaluate interventions (including alternatives to antibiotics) that reduce antimicrobial resistance in food production systems. Quantify animal health, public health, social, economic, and environmental impacts of antimicrobial interventions in food production systems.
Project Methods
The objective is to measure the economic impact of strategies to reduce antimicrobial use (AMU) in the U.S. beef production economy. An econometric model will be constructed for the U.S. beef sector, and the potential impact and response to various antimicrobial use (AMU) techniques in the beef production sector and various components of that sector will be estimated. The individual components modeled with include calve production from beef-cow operations, backgrounding or stocking operations where weaned calves are further fed primarily on pasture, and feedlots where cattle are finished on rations. Each of these components and their interactions are complex given the myriad of sizes and location of production. The movement of a weaned calf further through the production system can follow many paths from weaning directly to the feedlot, weaning with first some preconditioning before the feedlot, or further grazing after weaning and then finishing in a feedlot, or harvested as grass fed beef. Ownership through each of these channels can also be complex with some beef cow operators owning the physical facilities of each channel or retaining ownership of the calve through the channels. Because decisions are made by the operators, this myriad of production system overlaid with ownership patterns will require modeling to replicate this structure.To model this system of heterogenous production units, we will use an agent model approach where the agents are the decision makers or owners (Schreinemachers and Berger, 2011). Thus beef-cow producers will be modeled as heterogenous agents that vary in size, location, and production characteristics. Other modeled agents will be backgrounders and feedlots, again modeled as heterogeneous agents. We have previously completed research using agent modeling approaches (Verteramo Chiu, et al 2018).The agents will be modeled as profit maximizing agents subject to the constraints on resources available, and conditional on constraints on production practices, such as AMU. Behavior other than profit maximization might be modeled, but profit maximization will allow determining the impact of simulations on social welfare (profit) to the sector and the distributions of welfare across the sectors. Much previous work on agent analysis has entailed behavior rules, but there are now computer algorithms and software available for agent optimization behavior. We propose using the public available software by Troost and Berger (2015) which has agent optimization, but if that software does prove satisfactory, we will use other commercial software or write our own routines using the software R. Our plan is to begin with a reduced agent space and then build in heterogeneity and complexity.The antimicrobial reductions that will be analyzed in this agent model will include increased use of preconditioning of weaned calves, and various restrictions on AMU, such as restricting AMU for metaphylaxis, treating only sick animals, or a complete ban on AMU. These various treatments scenarios may alter the movement of cattle through the various channels and impact producers of various sizes and locations differently. For instance, a ban on AMU may channel more cattle through complete grass feeding with no placement in feedlots. Discussion with the other participants on this project may provide additional alternative scenarios to evaluate. The data necessary to model the agents will be collected from published data from studies on the various components of the beef sector (Field, 2018). Other data sources will include U.S. Agricultural Census data, and data from the Agricultural Management System (ARMS). Data may also become available from research completed from participants in this regional project.The second part of this proposal will use Principal-Agent theory to design efficient contracts to encourage AMU reduction. One such practice to reduce AMU is greater use of preconditioning of weaned calves before placement into feedlots, where preconditioning has been shown to reduce AMU (Avent, Ward and Lalman, 2004). Although shown to be profitable for feedlots, precondition is not predominant in the industry (Bryant and Blasi, 2005; Dhuyvetter et al., 2005; Schumacher et al., 2012). The question is why incomplete adoption of this practice? It may be because of insufficient transfer of the benefits accruing to feedlots back to individuals preconditioning calves, often the beef-cow producers. Principle-agent theory allows the design of a contract that is written by the principle, in this case the feedlot, that is acceptable to the agent (the preconditioner) and which ensures the fulfillment of the contract (no shirking).The principal writes the contract that will optimize the gain to himself/herself, but that optimization is subject to constraints. One constraint is a participation constraint to ensure that the agent will participate in the contract. The second constraint is an incentive compatibility constraint which requires that the agent fulfils the specifications of the contract (no shirking or cheating).The issue with preconditioning is that the performance of the preconditioned animal is not known with certainty. That means that the gain to the principal is not a fixed value but instead a distribution of values. Modeling in a principle agent framework will required generating these distributions and optimizing in an expected utility setting. Published cost of production and return budgets of the cost and benefits of preconditioning will be used to simulate the distribution of returns (Dennis, et al., 2018) to construct optimal contracts. It is likely that given the uncertainty of the benefits of preconditioning, that the optimal contract will entail some sharing of benefits between the principal and agent rather than a fixed payment. This will require the monitoring of the performance of preconditioned calves through the feedlot stage to final harvest.We have completed economic research on the U.S. dairy sector, including AMU reduction in the dairy sector (Lhermie, Tauer, and Grohn, 2018). Participation in this regional project will give us access to the individuals who are working on the science and production aspects of AMU reduction.ReferencesAvent, R.K., C.E. Ward and D.L. Lalman (2004) Market Valuation of Preconditioning Feeder Calves. J. of Ag. and Applied Economis 36(01):173-183.Dennis, E.J., T.C. Schroeder, D.G. Renter and D.L. Pendell (2018) Value of Arrival Metaphylaxis in U.S. Cattle Industry. J. of Ag. and Resource Economics 43(2):233-250Dhuyvetter, K.C., A.M. Bryant and D.A. Blasi (2005) Case Study: Preconditioning Beef Calves: Are Expected Premiums Sufficient to Justify the Practice? The Professional Animal Scientist21(6):502-514.Field, T.G. (2018) Beef Production and Management Decisions. Pearson PublishingLhermie, G., L.W. Tauer, Y.T. Grohn (2018b) An assessment of the economic costs to the U.S. dairy market of antimicrobial use restrictions. Preventive Veterinary Medicine160:63-67.Schreinemachers, P. and T. Berger (2011) An Agent-based Simulation Model of Human-Environment Interactions in Agricultural Systems. Environmental Modelling & Software 26: 845-859Schumacher, T., T.C. Schroeder, and G.T. Tonsor (2012). Willingness-to-Pay for Calf Health Programs and Certification Agents. J.of Agri. and Applied Economics44(2):191-202Troost, C. and T. Berger (2015) Dealing with Uncertainty in Agent-based Simulation: Farm-level Modeling of Adaptation to Climate Change in Southwest Germany. Amer. J. Agri.Economics97: 833-854Verteramo C.L.J., L.W. Tauer, Mohammad A.A., K. Kaniyamattam, R.L. Smith, and Y.T. Grohn (2018) An agent-based model evaluation of economic control strategies for paratuberculosis in a dairy herd. Journal of Dairy Science101:6443-6454.

Progress 10/01/20 to 09/30/21

Outputs
Target Audience:Scientists working on research to reduce the use of antimicrobials in beef feedlots. Beef feedlot operators. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?A post doctoral student learned how to construct and solve linear programming models of the U.S. beef sector. How have the results been disseminated to communities of interest?By published research. What do you plan to do during the next reporting period to accomplish the goals?A conceptual principle-agent model will be developed to investigate viable contracts to support the increased use of preconditioning of beef calves that enter feedlots.

Impacts
What was accomplished under these goals? Our objective was to estimate the cost effect from the following policies in feedlots: 1) using antimicrobials for disease prevention, control, and treatment; 2) using antimicrobials only for treatment of disease; and 3) not using antimicrobials for any reason. We modelled a typical U.S. feedlot, where high-risk cattle may be afflicted by diseases, namely respiratory diseases, liver abscesses and lameness, requiring antimicrobial therapy. We calculated the net revenue loss under each policy of antimicrobial use restriction. With moderate disease incidence, the median net revenue loss was $66 and $96 per animal entering the feedlot, for not using antimicrobials for disease prevention and control, or not using any antimicrobials, respectively, compared to using antimicrobials for disease prevention, control, and treatment. Losses arose mainly from an increase of fatality and morbidity rates, almost doubling for respiratory diseases in the case of antimicrobial use restrictions. In the case of antimicrobial use prohibition, decreasing the feeder cattle price by 9%, or alternatively, increasing the slaughter cattle price by 6.3%, would offset the net revenue losses for the feedlot operator. If no alternatives to antimicrobial therapy for prevention, control and treatment of current infectious diseases were implemented, policies that economically incentivize adoption of non-antimicrobial prevention and control strategies for infectious diseases would be necessary to maintain animal welfare and the profitability of beef production while simultaneously curbing antimicrobial use. Data was also generated to begin work on viable contracts between preconditioned calve producers and feedlot operations. Preconditioned calves are less susceptible to stress related production issues such as disease.

Publications

  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Kaniyamattam, Karun, Loren Tauer, Yrjo Grohn (2021). System economic costs of antibiotic use elimination in the US beef supply chain. Frontier Veterinary Science, 26 https://doi.org/10.3389/fvets.2021.606810


Progress 01/03/20 to 09/30/20

Outputs
Target Audience:Professionals and practioners who work in the animal health industry. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?A post-doctoral student learned to construct a sector beef production model and use linear programming to obtain less cost movement of beef through the system from birth to slaughter. How have the results been disseminated to communities of interest?Results were presented at the below conference. Kaniyamattam, Karun, Loren W. Tauer, Yrjo T. Grohn. The economic costs of antibiotic use constraints in U.S. integrated beef supply chains: A systems approach. Conference of Research Workers in Animal Diseases Virtual Conference, December 5-8, 2020 https://crwad.org/2020-crwad-conference/ What do you plan to do during the next reporting period to accomplish the goals?A conceptual principle-agent model will be developed to investigate viable contracts to support the increased use of pre-conditioning of beef calves to enter feedlots. Preconditioned calves are less susceptible to stress related production issues such as disease.

Impacts
What was accomplished under these goals? The United States (U.S.) beef industry is a prominent antibiotic user, with an annual average usage of 2500 tons of medically important antibiotics in 2018. Our objective was to estimate the economic costs of antibiotic use reduction in a conceptual U.S. beef supply chain, in order to mitigate the increasing risk of antibiotic resistance, by reducing antibiotic use. A conceptual network model of the U.S. integrated beef supply chain was developed, modeling the annual supply of 30 million animals through cow-calf, stockers, backgrounders, and feedlot operations. The entire supply chain was differentiated into 37 different nodes of production. Each node could only raise specific type of animals, differentiated based on the production process and health status, and hence could only follow a specific antibiotic use strategy. The cost as well as weight gain efficiency were calculated for each node, based on average U.S. beef production budgets. The linear programming solutions to this network model provided the least cost path of beef through the system, under various antibiotic use constraints. The budget calculated cost as well as weight gain efficiency of the 37 nodes, with an initial supply of 30 million calves, and a final demand of 16.14 million tons of slaughter ready fed cattle, were used as inputs/constraints to 3 different linear programming models, with different antibiotic use constraints. Our first model, the basic optimization model, which had no antibiotic use constraints, estimated that the minimum economic cost was $3,931 million to meet the final demand. It found not surprisingly that only high health status entering calves are optimal. Our second model, which was constrained to use all the calves irrespective of their health status, increased the system cost to $4,079 million. Our third model, which avoided the feedlots using antibiotics from the network, incurred a total cost of $4,661 million for antibiotic free beef production. The additional cost of $582 million for implementing antibiotic free beef production is relatively low, and less than one percent of total slaughter cash receipts of $67 billion.

Publications

  • Type: Conference Papers and Presentations Status: Accepted Year Published: 2020 Citation: Kaniyamattam K., LW Tauer, and YT Grohn. The economic costs of antibiotic use constraints in U.S. integrated beef supply chains: A systems approach. The Conference of Research Workers in Animal Diseases (CRWAD). December 5-8, 2020.