Source: VIRGINIA POLYTECHNIC INSTITUTE submitted to
GERM CELL AND EMBRYO DEVELOPMENT AND MANIPULATION FOR THE IMPROVEMENT OF LIVESTOCK
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
TERMINATED
Funding Source
HATCH
Reporting Frequency
Annual
Accession No.
1021446
Grant No.
(N/A)
Project No.
VA-136384
Proposal No.
(N/A)
Multistate No.
W-4171
Program Code
(N/A)
Project Start Date
Feb 9, 2020
Project End Date
Feb 11, 2021
Grant Year
(N/A)
Project Director
Lee, KI, .
Recipient Organization
VIRGINIA POLYTECHNIC INSTITUTE
(N/A)
BLACKSBURG,VA 24061
Performing Department
Animal Poultry Sciences
Non Technical Summary
Livestock production can be increased by understanding early embryo development. We hypothesize that assisted reproductivetechnology, such as in vitro fertilization (IVF) and genetic engineering, will allow us to understand the process of embryogenesisin livestock. We propose to examine various approaches to increase efficiency of IVF and genetic engineering in livestockanimals. Through our activity, we expect to develop more efficient ways to generate IVF and genetically engineered embryos inlivestock. These tools will be valuable sources for livestock production through assisted reproductive technology.
Animal Health Component
30%
Research Effort Categories
Basic
75%
Applied
25%
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
30139991050100%
Knowledge Area
301 - Reproductive Performance of Animals;

Subject Of Investigation
3999 - Animal research, general;

Field Of Science
1050 - Developmental biology;
Goals / Objectives
Understand the biology of gamete development, fertilization and embryogenesis including the underlying cellular and molecular mechanisms. Refine methods to produce animals by genetic engineering or genome editing for the improvement of livestock production efficiency and development of human biomedical models.
Project Methods
We plan to examine different approaches to optimize in vitro fertilization in pigs. We will also utilize new genetic engineering approaches to enhance the production of genetically engineered livestock.

Progress 02/09/20 to 02/11/21

Outputs
Target Audience: Nothing Reported Changes/Problems:Dr. Lee is no longer with Virginia Tech and we respectfully request this be considered the final report to terminate the project. What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? Dr. Lee is no longer with Virginia Tech and we respectfully request this be considered the final report to terminate the project.

Publications