Source: UNIVERSITY OF RHODE ISLAND submitted to
BIOLOGY, ECOLOGY & MANAGEMENT OF EMERGING DISEASE VECTORS
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
NEW
Funding Source
Reporting Frequency
Annual
Accession No.
1021058
Grant No.
(N/A)
Project No.
RI0020-NE1943
Proposal No.
(N/A)
Multistate No.
NE-1943
Program Code
(N/A)
Project Start Date
Oct 1, 2019
Project End Date
Sep 30, 2024
Grant Year
(N/A)
Project Director
Couret, NE.
Recipient Organization
UNIVERSITY OF RHODE ISLAND
19 WOODWARD HALL 9 EAST ALUMNI AVENUE
KINGSTON,RI 02881
Performing Department
Biological Sciences
Non Technical Summary
This work centers on the ecology of mosquitoes and ticks that transmit human pathogens.Our first aim is to understand what environmental and landscape factors allow invasive mosquitoes to establish and spread in Rhode Island. Successful invasions are quite rare, and it is estimated that only 10% of introduced species successfully invade and establish. The Zika vector Aedes albopictus exemplifies a tremendously successful ecological invasion in the United States. Surveillance has allowed public health officials to track the course of the invasion, yet there is limited information on the constraints governing the distribution of this organism. The current and potential range of this vector has recently been characterized and mapped based on surveillance data and global temperatures, but beyond temperature the forces that facilitate the invasion, persistence, and establishment of populations remain poorly understood. Our proposed work aims to improve our understanding of the invasion ecology of Ae. albopictus and predict how the current distribution of this Zika vector will expand in the years to come.Our second aim focuses on controlling mosquito populations through the application of carnivorous aquatic plants, commonly known as bladderworts, that naturally occur in ponds throughout US that can consume mosquito larvae, but also grow without mosquitoes present. Despite centuries of biological research on mosquito vectors, there is very little known about the role plants play in regulating mosquito populations. New methods for the control of mosquitoes are needed that are effective but also do not harm non-target insects such as beneficial pollinators. Few studies have experimentally studied the application of bladderworts as a biological control measure for mosquito larvae. We will examine the impacts of placing plants in backyards on local mosquito populations.
Animal Health Component
100%
Research Effort Categories
Basic
50%
Applied
50%
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
7213110107050%
7224099107050%
Goals / Objectives
Develop and strengthen effective surveillance and monitoring of disease vectors at local and regional scales, including the development and testing of novel trapping and vector/pathogen identification techniques. Under this objective, project participants will leverage and strengthen existing surveillance programs in a coordinated fashion to yield robust comparable data across large geographic scales. Determine the ecology and geographic distribution of invasive and native disease vectors under changing environmental conditions to enhance our ability to predict conditions leading to existing and novel animal and human diseases.
Project Methods
Project 1To obtain baseline oviposition data and to provide wild type Ae. albopictus females for laboratory experiments we will set oviposition traps consisting of black cups partially filled with water and an oak leaf infusion. The eggs are laid on a small piece of germination paper partially submerged in the cup. We are planning to install oviposition traps positioned in transects extending through the sampling site. The collections will be done weekly in the mosquito surveillance months of June to September. Oviposition cups will be changed at the same time. The germination paper with eggs will be brought to the RI DEM laboratory, hatched, the larvae counted, and identified to the species. To obtain baseline adult population data to determine the presence of current populations and the abundance over the study period we will use two methods, conventional BG Sentinel traps and the Prokopack hand held mosquito aspirator (Vazquez-Prokopec et al. 2009), weekly at each site. The Prokopack aspirates adult mosquitoes at rest into a collection cup using a motor that is attached to a hand-held pole in order to allow targeted collections around resting habitat (i.e. tire dumps, around homes, underside of leaves in bushes, etc.). We will test this recently developed tool in mosquito collection, the Prokoack, against the conventional BG Sentinel trap.Currently there are 4 weather monitor stations in the state of Rhode Island. We will place HOBO data loggers that monitor temperature, humidity, and light level at sampling sites for the duration of the sampling season. To analyze these data we will use a combination of statistical modeling and geographic information systems to create predictive models of the invasion potential of Ae. albopictus for RI based on the sampling data collected, experimentally estimated cold tolerance of the introduced Ae. albopictus eggs found in sampling, weather monitoring data, and spatial data on points of entry and calculated rates of spread for Ae. albopictus. We will develop a predictive spatio-temporal model of the invasion of the Zika vector for Rhode Island. This model will have broad applications for use in areas in the United States that are along the northern edge of the distribution of Ae. albopictus.Project 2Lab: To experimentally evaluate larval survival Aedine mosquitoes with and without bladderworts we propose an experiment to measure direct predation of bladderwort on larval survival of Ae. albopictus, Ae. aegypti, and Ae. japonicus. Larval survival will be evaluated by placing larvae at each instar stage into cups with bladderwort plant cuttings. The number of bladder traps, though the diet added daily will vary based on previous findings of conditions that range from poor to favorable for Ae. aegypti (Couret et al. 2014). Preliminary results show that in Ae. albopictus, 20 first instar larvae were fully predated within 3-5 days for most cups. This experiment will be repeated for each species individually and interspecific combinations in the laboratory. In the summer of 2018 experiments will be repeated in semi-natural field conditions at URI at the East Farm Agricultural Experiment Station in Kingston, RI A lux meter and a HOBO data logger will be used to evaluate differences in environmental conditions across semi-natural field sites.Field: We will test bladderwort-enhanced-trapping of mosquitoes compared to traditional-trapping at control sites without bladderworts. Bladderwort-enhanced-traps are those with plant cuttings either placed in gravid solution or in water with crush leaves for gravid and oviposition traps respectively. During the mosquito surveillance season in RI, a Couret lab research assistant will set bladderwort-enhanced traps at 10 sites around the state. Traditional-trapping will be done by RI state collaborators, RI Department of Environmental Management (RIDEM) Mosquito Abatement. RIDEM has 28 long-term mosquito trap sites, and a subset of 10 sites have gravid traps, light traps, and oviposition traps. Based, in part, on the results from the oviposition experiments in Objective 1, aspects of the traps will be refined, including the length of plant and number of bladders. Mosquito abundance, species distribution, and oviposition will be measured weekly across sites. Field: Based on the results from laboratory experiments we will evaluate bladderwort for biocontrol in semi-natural backyard conditions. We expect that this will be a pilot experiment in the first year. Recruiting households in urban and suburban neighborhoods, we will place bladderwort plants in backyard bird baths or artificial stagnant ponds. Rather than emptying birdbaths, as is the general recommendation, backyard larval habitats will be maintained with water throughout a 2 week period study period during which pupae will be removed. Based on our 2017 surveillance data this is the peak month for mosquito populations in Rhode Island. Backyards will be chosen based on the presence of an artificial larval habitat such as a bird bath, the number of additional larval habitats based on Breteau indices. Yards treated with bladderwort will be compared to control yards without bladderwort.

Progress 10/01/19 to 09/30/20

Outputs
Target Audience:We have worked directly with the Rhode Island State Department of Health and Department of Environmental Management including the State Mosquito Abatement Coordination Office to conduct surveillance of EEE and WNV vectors in the state of Rhode Island. These data supported public information on the risks of mosquito-borne illness in RI. Changes/Problems:Due to the COVID-19 pandemic, major changes were necessary in the approach to laboratory and field work. Fewer students could be engaged in this work. In addition, most of this work was conducted remotely. Finally, we are pivoting our research to focus more on modeling of vector-borne disease in order to maintain the safety of our students during this critical time in public health. What opportunities for training and professional development has the project provided?Despite a challenging year for conducting research in the field and in the lab, this grant provided the funding to support a graduate student pursuing a PhD in Biologicial and Ecological Sciences at the University of Rhode Island. This funding also supported the supplies and research of two undergraduates pursuing research in the Department of Biological Sciences during the summer, conducting surveillance of mosquito-borne disease. How have the results been disseminated to communities of interest?These results have been published in peer reviewed journals and disseminated through the network of the Northeaster Center for Excellence in Vector-borne Disease Network. What do you plan to do during the next reporting period to accomplish the goals?During the next reporting period we plan to extend the AI species identification model to US populations of vectors and work with local surveillance of mosquitoes to incorporate this method to strengthen surveillance of vectors. We also plan to use a geospatial approach to model EEE dynamics in New England to better understand the pattern of prevalence in vectors over space and time.

Impacts
What was accomplished under these goals? Through this project this year we developed and published an artificial intelligence model to identify mosquito vector identification using 2D whole body images taken under a stereomicroscope (Couret et al. 2020 PLOS NTD). We plan to continue this work to strengthen existing surveillance programs in a coordinated fashion with local, federal, and international partners using this novel methodology. Also through this project we proved thepotential for using a local carnivorous aquatic plant for the control of invasive mosquito vectors in the genus Aedes. This will enhance our ability to combat the invasion of pathogens spread by these vectors.

Publications

  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Delimiting cryptic morphological variation among human malaria vector species using convolutional neural networks Couret J, Moreira DC, Bernier D, Loberti AM, Dotson EM, et al. (2020) Delimiting cryptic morphological variation among human malaria vector species using convolutional neural networks. PLOS Neglected Tropical Diseases 14(12): e0008904. https://doi.org/10.1371/journal.pntd.0008904
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Couret, J.*, Notarangelo, M., Veera, S.!, LeClaire-Conway, N., Ginsberg, H.S. and LeBrun, R.L., 2020. Biological control of Aedes mosquito larvae with carnivorous aquatic plant, Utricularia macrorhiza. Parasites & Vectors, 13, pp.1-11.