Progress 07/01/17 to 06/30/22
Outputs
Target Audience:The immediate target audience is the fellows recruited into the training program. Scientists engaged in infectious disease and epidemiology research will benefit from the research conducted by each of the fellows. Finally, the future employers of the fellows are a key target audience of this program. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?Students interacted with several employers at the different stages of position searching and at the time of deciding where to go for the next professional stage. These students are going to be great mentors in the future based on all the experiences and opportunities made possible by this awrd How have the results been disseminated to communities of interest?3 articles in peer reviewed journals with high impact factor in their specialties. 2 more are being prepared. What do you plan to do during the next reporting period to accomplish the goals?
Nothing Reported
Impacts
What was accomplished under these goals?
The last year of the project, two students succesfully defended their doctoral dissertations Carsten Walker and Jamie Strickland. The DVM-PhD student Ashley Putman finished the research plan of her doctoral program and is now in a short internship at Wayne State University where she is acquiring experience on rodent models of liver disease and inflammation. This project was succesful in training at least 4 DVM-PhD students with 3 already in positions with the government (1), private companies (2).
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2022
Citation:
Putman AK, Sordillo LM, Contreras GA. The Link Between 15-F2t-Isoprostane Activity and Acute Bovine Endothelial Inflammation Remains Elusive. Front Vet Sci. 2022 Apr 29;9:873544. doi: 10.3389/fvets.2022.873544. PMID: 35573419; PMCID: PMC9100427.
- Type:
Journal Articles
Status:
Published
Year Published:
2022
Citation:
Putman AK, Gandy JC, Contreras GA, Sordillo LM. Oxylipids are associated with higher disease risk in postpartum cows. J Dairy Sci. 2022 Mar;105(3):2531-2543. doi: 10.3168/jds.2021-21057. Epub 2022 Jan 25. PMID: 35086706.
- Type:
Journal Articles
Status:
Published
Year Published:
2022
Citation:
Kuhn MJ, Sordillo LM. Inhibition of 20-hydroxyeicosatetraenoic acid biosynthesis by vitamin E analogs in human and bovine cytochrome P450 microsomes. J Anim Physiol Anim Nutr (Berl). 2022 Jan;106(1):55-60. doi: 10.1111/jpn.13547. Epub 2021 Apr 14. PMID: 33851747.
- Type:
Journal Articles
Status:
Published
Year Published:
2022
Citation:
Walker C, Sordillo LM, Contreras GA. Anandamide Alters Barrier Integrity of Bovine Vascular Endothelial Cells during Endotoxin Challenge. Antioxidants 2022, 11(8), 1461; https://doi.org/10.3390/antiox11081461
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Progress 07/01/20 to 06/30/21
Outputs
Target Audience:Professional students (veterinary medicine) and animal scientists. In the reporting period, this project supported the doctoral training of 3 professional students (2 graduated from veterinary medicine already) Changes/Problems:Dr. Lorraine Sordillo, the PI of this proposal, passed away in 2021 after 2 years of fighting cancer. The members of the Department of Large Animal Clinical Sciences at MSU supported all the students in her lab to continue with their doctoral training. I, Andres Contreras, am advising these graduate students and they will finish with their projects in 2022 What opportunities for training and professional development has the project provided?The project trained during 2021 a total of 3 DVM PhD students. How have the results been disseminated to communities of interest?The graduate students supported by this program presented their research in regional, national, and international scientific and extension meetings. What do you plan to do during the next reporting period to accomplish the goals?The project will be finalized this year. The research team is preparing a new submission to continue training the future generation of veterinarian scientists.
Impacts
What was accomplished under these goals?
The project trained during 2021 a total of 3 DVM PhD students. The rigorous training in the Comparative Medicine and Integrative Biology graduate program of the College of Veterinary Medicine at Michigan State University developed knowledge and expertise in the areas of immunobiology, lipidomics, herd health, nutrition in the DVM PhD students. All graduate students trainined by this program published 1-3 peer reviewed articles in the journals with highest impact factor within veterinary medicine. One of the students is now working as AAAS Science & Technology Policy Fellow at the Department of Homeland Security. The other 2 students are finishing their doctoral programs and have alligned postdoctoral positions in immunobiology to complete their research training.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Putman AK, Contreras GA, Sordillo LM. Isoprostanes in Veterinary Medicine: Beyond a Biomarker. Antioxidants (Basel).
2021 Jan 20;10(2):145. doi: 10.3390/antiox10020145. PMID: 33498324; PMCID: PMC7909258.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Strickland JM, Wisnieski L, Mavangira V, Sordillo LM. Serum Vitamin D Is Associated with Antioxidant Potential in Peri-
Parturient Cows. Antioxidants (Basel). 2021 Sep 6;10(9):1420. doi: 10.3390/antiox10091420. PMID: 34573052; PMCID:
PMC8471689.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Walker CCF, Brester JL, Sordillo LM. Flunixin Meglumine Reduces Milk Isoprostane Concentrations in Holstein Dairy
Cattle Suffering from Acute Coliform Mastitis. Antioxidants (Basel). 2021 May 24;10(6):834. doi: 10.3390/antiox10060834.
PMID: 34073753; PMCID: PMC8225098.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Mavangira V, Kuhn MJ, Abuelo A, Morisseau C, Hammock BD, Sordillo LM. Activity of sEH and Oxidant Status during
Systemic Bovine Coliform Mastitis. Antioxidants (Basel). 2021 May 20;10(5):812. doi: 10.3390/antiox10050812. PMID:
34065244; PMCID: PMC8161397.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Kuhn MJ, Sordillo LM. Inhibition of 20-hydroxyeicosatetraenoic acid biosynthesis by vitamin E analogs in human and
bovine cytochrome P450 microsomes. J Anim Physiol Anim Nutr (Berl). 2022 Jan;106(1):55-60. doi: 10.1111/jpn.13547.
Epub 2021 Apr 14. PMID: 33851747.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Putman AK, Gandy JC, Contreras GA, Sordillo LM. Oxylipids are associated with higher disease risk in postpartum cows.
J Dairy Sci. 2022 Mar;105(3):2531-2543. doi: 10.3168/jds.2021-21057. Epub 2022 Jan 25. PMID: 35086706.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Kuhn MJ, Sordillo LM. Vitamin E analogs limit in vitro oxidant damage to bovine mammary endothelial cells. J Dairy Sci.
2021 Jun;104(6):7154-7167. doi: 10.3168/jds.2020-19675. Epub 2021 Mar 25. PMID: 33773776.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Kuhn MJ, Mavangira V, Sordillo LM. Invited review: Cytochrome P450 enzyme involvement in health and inflammatorybased
diseases of dairy cattle. J Dairy Sci. 2021 Feb;104(2):1276-1290. doi: 10.3168/jds.2020-18997. Epub 2020 Dec 23.
PMID: 33358163.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Strickland JM, Wisnieski L, Herdt TH, Sordillo LM. Serum retinol, ?-carotene, and ?-tocopherol as biomarkers for disease
risk and milk production in periparturient dairy cows. J Dairy Sci. 2021 Jan;104(1):915-927. doi: 10.3168/jds.2020-18693.
Epub 2020 Nov 6. PMID: 33162081.
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Putman, A.K., and L.M. Sordillo. Isoprostanes increase endothelial cell barrier integrity independent of altered
inflammatory gene expression. Oral. American Dairy Science Association (Virtual). 2021.
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Putman, A.K., L.M. Sordillo, and G.A. Contreras. Isoprostanes increase RAW 264.7 viability and ROS production in a
model of inflammation. Oral. Michigan State University Phi Zeta Day. East Lansing, MI. October, 2021.
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Putman, A.K., and L.M. Sordillo. Isoprostanes increase endothelial cell barrier integrity independent of altered
inflammatory gene expression. Oral. Conference of Research Workers in Animal Diseases. Chicago, IL. December 6,
2021.
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Walker, C.C.F. and Sordillo, L.M. Anandamide enhances barrier integrity of bovine vascular endothelial cells during
endotoxin challenge via cannabinoid receptor-1 activation. Poster presented at: International Cannabinoid Research
Society. 31st Annual Symposium; 2021 Jun 21-24; Jerusalem, Israel (Virtual attendance).
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Walker, C.C.F. and Sordillo, L.M. Bioactivity of the endocannabinoid arachidonoylethanolamide in cultured bovine
endothelial cells. Presentation presented at: International Cannabinoid Research Society. 31st Annual Symposium; 2021
Jul 11-14; Virtual.
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Walker, C.C.F. and Sordillo, L.M. AEA enhanced bovine vascular endothelial cell barrier integrity during LPS challenge
mediated by CB1. Presentation presented at: European Federation of Animal Science. 72nd Annual Meeting. 2021 Aug 30
Sep 3; Davos, Switzerland.
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Walker, C.C.F. and Sordillo, L.M. AEA enhanced bovine vascular endothelial cell barrier integrity during LPS challenge
mediated by CB1. Presentation presented at: Conference of Research Workers in Animal Diseases. 2021 Dec 3-7;
Chicago, IL, USA.
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Progress 07/01/19 to 06/30/20
Outputs
Target Audience:The immediate target audience is the fellows recruited into the training program.Scientists engaged in infectious disease, agriculture biosecurity and epidemiology research will benefit from the research conducted by each of the fellows.Finally, the future employers of the fellows are a key target audience of this program. Changes/Problems:The COVID shut down did impede some progress of the Fellows as they were not permitted to engage in on campus research for several months. The Fellows are now re-engaged in their research and should be able to meet their original graduation goals. What opportunities for training and professional development has the project provided?The current group of Fellows were actively engaged in research training, attended several virtual on-campus scientific presentations, participated in career development workshops offered by MSU's graduate school, and attended virtual annual scientific meetings associated with their respective fields of study.They continue to grow this past year in their ability to think critically and to synthesize complex concepts across several disciplines. The program also has increased the interaction of faculty across the Michigan State University campus to further expose these Fellows to related disciplines. How have the results been disseminated to communities of interest?Dissemination activities for this program include presentations at scientific meetings, publications in peer-reviewed journals, research awards received, and other evidence of scholarship for each of the fellows. What do you plan to do during the next reporting period to accomplish the goals?Goals for the next reporting period will be to ensure that all 3 Fellows continue with their academic progress.The continued engagement of each Fellow in professional activities will be encouraged and facilitated as needed by the program faculty.The primary goal will be to ensure that Drs. Putman and Strickland are prepared to take their comprehensive examinations before the end of the coming year.
Impacts
What was accomplished under these goals?
Three DVM professionals were successfully recruited into the PhD graduate program including Drs. Strickland, Kellogg, and Putman.All three Fellows are progressing appropriately towards their degree program.The Fellows not only have identified primary mentors, but also have formed their graduate advisory committees.The Fellows recently completed their annual performance reviews and were mentored to develop a Professional Development Plan for the 2020-2021 academic year.Drs. Kellogg and Strickland have completed their coursework and are fully engaged in their dissertation research.Dr. Kellogg is on track to finish his program in 2021. Dr. Strickland is on track to finish her program in early 2022.Dr. Putman entered the program as a dual DVM/PhD candidate.Dr. Putman has completed all the requirements for the DVM degree in 2020 and is taking a rigorous schedule of coursework and is actively engaged in her dissertation research.Several of the Fellows were successful in publishing peer-reviewed manuscripts related to their dissertation research.Professional networking also occurred at virtual annual scientific meetings during the past year.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2020
Citation:
Kuhn, M., A. Putman, and L.M. Sordillo. 2020. Widespread basal cytochrome P450 expression in extra-hepatic bovine tissues and isolated cells. J. Dairy Sci. 103:625-637.
- Type:
Journal Articles
Status:
Accepted
Year Published:
2020
Citation:
Strickland, J., L. Wisnieski, T. Herdt, and L.M. Sordillo. 2020. Serum retinol, ?-carotene, and ?-tocopherol as biomarkers for disease risk and milk production in periparturient dairy cows. J. Dairy Sci. accepted.
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Progress 07/01/18 to 06/30/19
Outputs
Target Audience:The immediate target audience is the fellows recruited into the training program. Scientists engaged in infectious disease and epidemiology research will benefit from the research conducted by each of the fellows.Finally, the future employers of the fellows are a key target audience of this program. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?The current group of Fellows were actively engaged in research training, attended several on-campus scientific presentations, participated in career development workshops offered by MSU's graduate school, and attended annual scientific meetings associated with their respective fields of study.They have grown this past year in their ability to think critically and to synthesize complex concepts across several disciplines. The program also has increased the interaction of faculty across the Michigan State University campus. How have the results been disseminated to communities of interest?Dissemination activities for this program include presentations at scientific meetings, publications in peer-reviewed journals, research awards received, and other evidence of scholarship for each of the fellows. What do you plan to do during the next reporting period to accomplish the goals?Goals for the next reporting period will be to ensure that all 3 Fellows continue with their academic progress.The continued engagement of each Fellow in professional activities will be encouraged and facilitated as needed by the program faculty.The primary goal will be to ensure the Fellows are prepared to take their comprehensive examinations before the end of the coming year.
Impacts
What was accomplished under these goals?
Three DVM professionals were successfully recruited into the PhD graduate program including Drs. Strickland, Kellogg, and Putman.All three Fellows are progressing appropriately towards their degree program.The Fellows not only have identified primary mentors, but also have formed their graduate advisory committees.The Fellows recently completed their annual performance reviews and were mentored to develop a Professional Development Plan for the 2019-2020 academic year.In addition to taking a rigorous schedule of coursework, all are actively engaged in their dissertation research.Several of the Fellows were successful in publishing peer-reviewed manuscripts related to their dissertation research.Professional networking also occurred at annual scientific meetings during the past year.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Strickland, J., D. Lyman, L. M. Sordillo, T. H. Herdt and J. Buchweitz. 2019. Effects of super nutritional hepatic copper accumulation on hepatocyte health and oxidative stress in dairy cows. Vet. Med. International. 2019,3642954.
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Putman, A.K., J.L. Brown, J.C. Gandy, A. Abuelo, and L.M. Sordillo. 2019. Oxylipid profiles of dairy cattle vary throughout the transition into early involution. J. Dairy Sci. 102:2481-2491
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Progress 07/01/17 to 06/30/18
Outputs
Target Audience:The immediate target audience is the fellows recruited into the training program.The fellows received formal classroom instruction, were involved with experimental research training in their respective fields of study and were engaged in several career development activities.Scientists engaged in infectious disease and epidemiology research will benefit from the research conducted by each of the fellows.Finally, the future employers of the fellows are a key target audience of this program. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?The current group of fellows were actively engaged in research training, attended several on-campus scientific presentations, participated in career development workshops offered by MSU's graduate school, and attended annual scientific meetings associated with their respective fields of study.They have grown this past year in their ability to think critically and to synthesize complex concepts across several disciplines. The program also has increased the interaction of faculty across the Michigan State University campus. How have the results been disseminated to communities of interest?Dissemination activities for this program include presentations at scientific meetings, publications in peer-reviewed journals, research awards received, and other evidence of scholarship for each of the fellows.Professional networking also occurred at annual scientific meetings during the 2017-2018 year. What do you plan to do during the next reporting period to accomplish the goals?Goals for the next reporting period will be to ensure that all 3 Fellows continue with their academic progress.The continued engagement of each Fellow in professional activities will be encouraged and facilitated as needed by the program faculty.
Impacts
What was accomplished under these goals?
Three DVM professionals were successfully recruited into the PhD graduate program including Drs. Strickland, Kellogg, and Putman.We were able to recruit highly qualified women and a man as National Needs Fellows under this program, thus enhancing the diversity of the graduate student population. The specific areas of research focus represented by this cohort of fellows include immunopathogenesis, nutritional immunology, and microbial epidemiology. Each of the fellows proved to be highly qualified individuals that met or exceeded the performance parameters of the typical graduate student in the Comparative Medicine and Integrated Biology graduate program. They all are in the process of completing the rigorous course requirements with excellent GPAs to date.All fellows have identified a primary mentor and are actively engaged in their dissertation research.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2018
Citation:
Putman, A.K., J.L. Brown, J.C. Gandy, L. Wisnieski and L.M. Sordillo. 2018. Changes in biomarkers of nutrient metabolism, inflammation, and oxidative stress in dairy cows during the transition into the early dry period. J. Dairy Sci. 101:9350-9359.
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