Source: CORNELL UNIVERSITY submitted to NRP
EFFICACY OF CONSUMPTION OF MICRONUTRIENT DIETARY SUPPLEMENT BY PREGNANT WOMEN
Sponsoring Institution
State Agricultural Experiment Station
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0181776
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
Feb 26, 1999
Project End Date
Feb 25, 2007
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
CORNELL UNIVERSITY
(N/A)
ITHACA,NY 14853
Performing Department
NUTRITIONAL SCIENCES
Non Technical Summary
(N/A)
Animal Health Component
(N/A)
Research Effort Categories
Basic
100%
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
70260101010100%
Goals / Objectives
To assess the efficacy of twice daily consumption of a micronutrient dietary supplement by pregnant women, and on into the first weeks of lactation. Using information collected at (1) the baseline around the seventh month of pregnancy, (2) in the two weeks prior to delivery and (3) four weeks post-partum differences between women consuming the fortified supplement compared with a group consuming an identical appearing non-fortified supplement will be assessed. Data collection will include among others clinical assessment, anthropometry, serum Vitamin A, hemoglobin, serum ferritin, urinary iodine and breastmilk vitamin A. The status of the newborn will also be assessed soon after birth and at six months of age.
Project Methods
Pregnant women attending pre-natal clinics in Mpwapa District, Tanzania will form the subjects of the research. Those that satisfy study entry criteria will be asked to participate, their ethical rights will be explained, and voluntary agreement reached. The study is a double blind study. Participating women will be randomly assigned to either the fortified or unfortified supplement group. They will be given sachets of supplement and instructed to mix one sachet with boiled water twice a day for consumption with a meal. The two supplements will be identical in appearance and taste. The fortified supplement will contain 10 micronutrients to satisfy between 50 and 140 percent of the RDA's. Mothers will return regularly for examination, and continue to consume the supplement for four weeks post-partum.

Progress 02/26/99 to 02/25/07

Outputs
The successful clinical trials in Tanzania, one in school children and the other in pregnant and lactating women, has led to widespread propagation of multiple micronutrient supplementation in Africa, Asia and elsewhere. In Tanzania such supplementation is being started in women with HIV/AIDS. In Tanzania the Investigator is working with others to control anemia on Chole Island. The results were presented at the Micronutrient Forum in Istanbul, Turkey in April 2007.

Impacts
Based on this work in Tanzania important benefits have been obtained in Bangladesh. A product identical to teach developed and used in Tanzania improved the health of adolescent girls there. The Procter and Gamble Corporation in Cincinnati are promoting similar products in several counties.

Publications

  • Ash D, Takala S and Latham MC. 2007 Community driven comprehensive anemia control program can reduce anemia and improve overall health and nutritional status. Abstract in Micronutrient Forum Istanbul, Turkey, Istanbul, Turkey T15:72.


Progress 01/01/06 to 12/31/06

Outputs
Based on the successful clinical trials in Tanzania action this year continued to be made to propagate the wide use of multiple micronutrient dietary supplements in Africa and elsewhere. Meetings were held with scientists from the Procter and Gamble Corporation of Cincinnati. The PI visited Tanzania, Malaysia and Laos. He also gave an invited presentation on the control of micronutrient deficiencies at the 2nd International Food and Nutrition Conference at Tuskegee University in October 2006.

Impacts
The project has led to trials and also marketing of the multiple micronutrient supplement in several countries in Asia, Africa and Latin America. This will have benefited many people.

Publications

  • Latham, M.C. 2006. People's struggle for health rights. UN Standing Committee on Nutrition News 32:37-39.


Progress 01/01/05 to 12/31/05

Outputs
Following the successful conclusion and publication of results of our successful clinical trials in Tanzania efforts are now concentrated on moving to action to control micronutrient deficiencies. The PI organized and chaired a symposium on Dietary Micronutrient Supplementation at the International Congress of Nutrition in Durban, South Africa. Speakers from six countries gave talks.

Impacts
The impact of the project was clear at the Congress mentioned above. Successful similar trials were described in the Philippines and Bangladesh, and implementation in other countries.

Publications

  • Latham MC, Tatala SR, Ash DM, Makola D and Mehansho H. 2005. Efficacy trials in Tanzania using a micronutrient dietary supplement in school children and pregnant women. Proceedings of IUNS Congress, Durban, South Africa.


Progress 01/01/04 to 12/31/04

Outputs
As reported previously the two efficacy trials to determine the benefits of consuming our unique micronutrient dietary supplement have had a major influence. This led to an international colloquium hosted by Procter and Gamble in Cincinnati. The Proceedings under the editorship of the Investigator were published as a whole 100 page issue of the UN Food and Nutrition Bulletin. The Investigator visited Tanzania in October where a detailed proposal was completed to seek funds for a project in which a similar micronutrient supplement will be offered to 1.5 million people in the Arusha Region.

Impacts
The project has influenced research and action in the Philippines, Bangladesh, Venezuela and Nicaragua in the area of micronutrient malnutrition, which impacts over 2 billion people worldwide. This new approach to controlling prevalent micronutrient deficiencies in pregnant women, children and others is being widely considered.

Publications

  • Tatala, R.T. 2004. Anaemia and iron deficiency in children and women in Tanzania. Effects of dietary iron intake, low iron bioavailability and iron supplementation with multiple micronutrient beverage. Chalmers Tekniska Hogskola 2185:1-69.


Progress 01/01/03 to 12/31/03

Outputs
The results of the efficacy trial in Tanzania showed nutritional benefits of our micronutrient dietary supplement to pregnant and lactating women were published and publicized. It led to a Colloquium organized by P&G in Cincinnati which will be published as a whole journal issue. A proposal in Tanzania will use this work to benefit about 1.5 million people.

Impacts
The project has had an impact in that as a result of the research Procter and Gamble are now marketing a product in Latin America; a trial is going on in Bangladesh; and Tanzania is taking action.

Publications

  • Makola, D., Ash, D.M., Tatala, S.R., Latham, M.C., Ndossi, G. and Mehansho, H. 2003. A micronutrient fortified beverage prevents iron deficiency, reduces anemia, and improves the hemoglobin concentration of pregnant Tanzanian women. J. Nutr. 133:1339-1346.


Progress 01/01/02 to 12/31/02

Outputs
Further analysis of clinical, biochemical and nutritional data on 400 pregnant and lactating women in Tanzania was conducted. Several papers were submitted for publication, and one is in press. An international colloquium chaired by the Investigator based on this project was organized and held in Cincinnati.

Impacts
The research has had a major impact on the Procter and Gamble Company who are now marketing the supplement and funded an International Colloquium on the topic. The work has also influenced a similar project in Bangladesh and further planning in Tanzania.

Publications

  • Latham, M.C., Tatala, S.R., Makola, D., Ash, D.M., Ndossi, G.D. and Mehansho, H. 2002. Efficacy trials of a micornutrient dietary supplement -- The Tanzanian clinical studies in school children and pregnant women. Abstract in Micronutrient Colloquium Program.


Progress 01/01/01 to 12/31/01

Outputs
An analysis of data collected on 400 pregnant and lactating women in Tanzania showed that the supplement improved iron and vitamin A status, and the content of vitamin A in breastmilk.

Impacts
The research is leading UNICEF and TAnzanian institutions to plan local manufacture of a similar supplement. Procter and Gamble have moved to market the product in Venezuela.

Publications

  • Latham, M.C., Ash, D., Ndossi, G., Mehansho, H. and Tatala, S. 2001. Micronutrient dietary supplements - a new fourth approach. Archivos Latinoamericanos de Nutricion 51:37-41


Progress 01/01/00 to 12/31/00

Outputs
Data collection was completed in Tanzania from 400 pregnant women, many of whom were followed into lactation. Anemia was prevalent but iron status improved with supplementation.

Impacts
Because of the work in Tanzania use of the supplement is being tried in Bangladesh and the Philippines.

Publications

  • Ramakrishnen U., Martorell R., Latham M.C. and Abel R. 2000. Dietary vitamin A intakes in preschool children in South Asia. Journal of Nutrition 129:2021-2029.


Progress 01/01/99 to 12/31/99

Outputs
Having completed a study on micronutrient supplementation in children, we began in 1999 an efficacy trial in Tanzania on pregnant and lactating mothers. The work in Tanzania has led to our experimental product being widely marketed by Procter and Gamble in the Philippines where the P.I. reported twice on this research. A presentation was also given at an international meeting in South Africa.

Impacts
The project positively influences the health and nutrition of mothers and children. There will also be an impact on productivity.

Publications

  • Latham, M.C., Ash, D., Ndossi, G.D. and Tatala, S.R. 1999. Trial of a micronutrient dietary supplement to control deficiencies and improve child growth. Proceedings of Philippine Association of Nutrition 50:1-6.
  • Ash, D.M., Latham, M.C., Tatala, S.R., Mehansho, H., Ndossi, G.D. and Frongillo, E.A. 1999. Trail of a micronutrient beverage supplement in school children and pregnant women in Tanzania. Report of the XIX International Vitamin A Consultative Group W23:90.