Source: PURDUE UNIVERSITY submitted to
HIGH INTENSITY SWEETENERS: SCIENCE AND CONTROVERSY
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
TERMINATED
Funding Source
Reporting Frequency
Annual
Accession No.
1007868
Grant No.
2016-67017-24598
Project No.
IND2015-05916
Proposal No.
2015-05916
Multistate No.
(N/A)
Program Code
A1361
Project Start Date
Jan 1, 2016
Project End Date
Dec 31, 2016
Grant Year
2016
Project Director
Mattes, R.
Recipient Organization
PURDUE UNIVERSITY
(N/A)
WEST LAFAYETTE,IN 47907
Performing Department
Nutrition Science
Non Technical Summary
The topic of high intensity sweeteners (HIS) and health is not new, though interest is particularly high now and continues to grow. The resurgence in interests has stemmed largely from recent findings that sweet "taste" receptors are located throughout the body, include the GI tract where they are located on enteroendocrine cells. This has prompted rethinking about whether the various HIS, once considered inert, may actually exert important biological effects with a wide spectrum of health outcomes.The issue of high intensity sweeteners and health has been addressed in sessions at multiple scientific meetings. However, often only one side of the issue is presented. In other instances, opposing views are showcased. This is fine if the goal is to disseminate perspectives, but neither approach serves the purpose of critically reviewing the evidence and drawing reasoned, science-based conclusions. To achieve this end, it is necessary to move beyond presenters, to the science itself. This proposed conference is designed for that purpose.We propose to hold a highly structured international conference with invited presenters and discussants. The unique design of the program aims to highlight the state of the science stripped from hyperbole and innuendo. In addition to presentations related to the ecology of sweet taste, mechanisms of sweet taste and trends in high intensity sweetener use, the specific topics often linked to health concerns that will be considered are, HIS use and A) gut digestive, endocrine and absorptive function B) microbiota; C) brain reward pathways; and D) appetite, food intake and energy balance. Impressions of the science by all attending the meeting will be tracked with real-time computer polling. However, the greater impact of the meeting will likely be achieved through publication of the proceedings in a special issue of Physiology & Behavior (option already confirmed).The goal of the conference is to highlight the science related to the heal effects of HIS so that policy makers, clinicians and consumers can make informed decisions about their use.
Animal Health Component
0%
Research Effort Categories
Basic
(N/A)
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
70120991010100%
Goals / Objectives
This funding is to support an international conference. The goals areto hold the conference and publish the proceedings.
Project Methods
We will host a conference. Speakers will submit manuscriptson their topic. These willbe peer-reviewed and included in the proceedings. Additionally, thediscussion following presentations will be recorded,transcribed and included in the proceedings.

Progress 01/01/16 to 06/30/16

Outputs
Target Audience:We were funded to host a conference. It was advertised widely to many diverse audiences including: scientists in industry and academia, students, consumers, clinical professionals (e.g. dietitians, physicians), government employees, and lay members of the community. The proceedings of the conference will be published in a peer-reviewed journal where the primary target audience is comprised of scientists, clinicians and policy makers. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?The conference was hosted by the Ingestive Behavior Research Center at Purdue University. Numerous students in the Center volunteered to help organize and host the conference. They gained considerable understanding of the steps required to host an international meeting. The students also held a poster session attended by all speakers and attendees where they received constructive feedback on the research they are conducting. The students also interacted socially with established scientists and gained insights on professional behavior. Finally, they were active participants in the conference and participated in the question and answer sessions. How have the results been disseminated to communities of interest?The conference was a venue to share ideas and new knowledge. The proceedings will further disseminate state-of-the-art knowledge on the topic of low calorie sweeteners and health. What do you plan to do during the next reporting period to accomplish the goals?We expect the proceedings to be published in the next few months so there will be no additional funding period.

Impacts
What was accomplished under these goals? The conference was held September 22-24, 2015. All speakers presented at the conference and submitted manuscripts on their assigned topic. At this point, several manscripts have been published ahead of print (the citation provided is only for the introductory manuscript to the full proceedings), several are being revised in response to reviewer comments and one paper is still undergoing review. All will be published as a special issue of the journal, Physiology & Behavior. Allare on track to meet all of the stated goals.

Publications

  • Type: Conference Papers and Presentations Status: Under Review Year Published: 2016 Citation: Mattes RD. Low Calorie Sweeteners: Science and Controversy Conference proceedings. Physiology & Behavior http://dx.doi.org/10.1016/j.physbeh.2016.01.005