Progress 03/18/14 to 09/30/15
Outputs Target Audience:Members of the target audience include veterinary and biomedical orthopaedic researchers and veterinary surgeons. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?Two graduate students(Drs. MartaBianchessi and Kalyn Herzog)and a DVM student (Michelle Picione BS)worked on this project and gained considerable experience with animal model-based research, transcriptional profiling and bone histomorphometry. How have the results been disseminated to communities of interest?The results have been disseminated through presentations at several scientific conferences (Veterinary Orthopaedic Society, American College of Veterinary Pathologists, and the American College of Wound Healing and Regeneration). What do you plan to do during the next reporting period to accomplish the goals?
Nothing Reported
Impacts What was accomplished under these goals?
We determined that prior bisphosphonate threatment does interfere with cortical bone repair, where the adjacent periosteum is removed. This condition simulates a displaced fracture site, where periosteal stripping is commmon. Periosteal and endosteal callus volumes were also reduced by prior bisphosphonate therapy, but these differences did not reach statistical significance.
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Progress 03/18/14 to 09/30/14
Outputs Target Audience: Orthopaedic researchers and surgeons/clinicians with an interest in bone repair Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided? An MS degree student, a visiting Veterinary Profesor from Brazil (sabbatical leave) and two DVM students have been integrally involved in the study. How have the results been disseminated to communities of interest? Results are still pending. What do you plan to do during the next reporting period to accomplish the goals? Complete the histomorphometric analyses, collate the complete data sets and submit a manuscript of the study for publication. It is also likely that the study will be presented at scientific conferences over the next 12-18 months.
Impacts What was accomplished under these goals?
We have completed the surgical model phase of the project, the specimen collections, CT image analyses and microCT image analyses. Processing of the specimens for histomorphometric analyses is being completed. The final analytical aspect of the study will involve the measurement of new bone formation and cortical bone repair in the histological sections.
Publications
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